Heat shock proteins of malaria [electronic resource] / Addmore Shonhai, Gregory L. Blatch, editors.
Shonhai, Addmore, editor of compilation.; Blatch, Gregory L., editor of compilation.
2013
QR201.M3
Available Online

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Title Heat shock proteins of malaria [electronic resource] / Addmore Shonhai, Gregory L. Blatch, editors.
ISBN 9789400774384 electronic book
9400774389 electronic book
9789400774377
DOI https://doi.org/10.1007/978-94-007-7438-4
Published Dordrecht : Springer, [2013?]
Copyright ©2014
Language English
Description 1 online resource (viii, 223 pages) : illustrations (some color)
Item Number 10.1007/978-94-007-7438-4 doi
Call Number QR201.M3
Dewey Decimal Classification 614.5/32
Summary This book describes the role of heat shock proteins in the life cycle of malaria parasites. The work includes a general introduction on the structural and functional features of heat shock proteins. The main focus is on the role of heat shock protein families from Plasmodium falciparum, their role in protein folding and in the development of malaria pathology. The functions of individual families of heat shock proteins from plasmodium species and their cooperation in functional networks is described. Subcellular and extracellular organelles such as the apicoplast and the Maurer's Clefts which are associated with plasmodium species, are discussed in detail. The role of heat shock proteins in the development and function of these organelles structures are highlighted. Although conceding that heat shock proteins may not be ideal antimalarial drug targets, prospects of targeting heat shock proteins in antimalarial drug discovery either directly and/or in combination therapies are explored.
Note Includes index.
Access Note Access limited to authorized users.
Source of Description Description based on online resource; title from PDF title page (SpringerLink, viewed September 24, 2013).
Added Author Shonhai, Addmore, editor of compilation.
Blatch, Gregory L., editor of compilation.
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All Resources
Introduction: The importance of molecular chaperones in survival and pathogenesis of the malaria parasite Plasmodium falciparum
General structural and functional features of molecular chaperones
The role of Hsp70s in the development and pathogenicity of Plasmodium species
Role of the Hsp40 family of proteins in the survival and pathogenesis of the malaria parasite
Role of Hsp90 in Plasmodium falciparum malaria
The role of parasite heat shock proteins in protein trafficking and host cell remodeling
Role of heat shock proteins in immune modulation in malaria
Establishment of Plasmodium falciparum extracellular compartments in its host erythrocyte
Chaperones and Proteases of Plasmodium falciparum
Heat shock proteins as targets for novel anti-malarial drugs
Heat shock proteins of Malaria: What do we not know, and what should the future focus be?

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