Biomolecular imaging at high spatial and temporal resolution in vitro and in vivo [electronic resource] / by Thomas H. Sharp.
2014
QH212.E4
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Title
Biomolecular imaging at high spatial and temporal resolution in vitro and in vivo [electronic resource] / by Thomas H. Sharp.
Author
Sharp, Thomas H., author.
ISBN
9783319021591 electronic book
3319021591 electronic book
9783319021584
3319021591 electronic book
9783319021584
Published
Cham : Springer, 2014.
Language
English
Description
1 online resource.
Item Number
10.1007/978-3-319-02159-1 doi
Call Number
QH212.E4
Dewey Decimal Classification
502.825
Summary
As part of a collaboration between two different groups in chemistry and biochemistry, Thom Sharp presents here his thesis work on the development of new methods for cryoelectron microscopy. Throughout his PhD, Thom had to master a whole range of techniques including modelling, molecular biology and microscopy. Using these skills to tackle an outstanding problem, the pursuit of high-resolution structures of peptide-based materials, Thom highlights in this thesis his newly developed methods for analysing and processing this particular type of electron microscopy data. This thesis gives the first molecular description of a de-novo designed peptide-based material. In general, this research will have a huge impact on the peptide assembly field, and also in electron microscopy as it introduces new methods and approaches, all of which are Thom's inventions and are described in this thesis.
Dissertation Note
Ph.D. University of Bristol [2012?]
Access Note
Access limited to authorized users.
Source of Description
Description based on print version record.
Series
Springer theses.
Available in Other Form
Biomolecular imaging at high spatial and temporal resolution in vitro and in vivo
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Table of Contents
Biomolecules & Microscopy
Materials and Methods
Experimental Methods
Imaging Methods
Experimental Results
Towards an Atomistic Structure of a De Novo Designed Peptide Fibre
Developing Novel Probes for Correlative Light Electron Microscopy.
Materials and Methods
Experimental Methods
Imaging Methods
Experimental Results
Towards an Atomistic Structure of a De Novo Designed Peptide Fibre
Developing Novel Probes for Correlative Light Electron Microscopy.