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Part I: Introduction
Chapter 1: Overview of Metal-on-Metal Implants
Chapter 2: Bearing Surfaces for Joint Replacement: New Materials or New Problems?
Part II: Clinical
Chapter 3: Outcome Studies for Metal-on-Metal Bearings: What Evidence-Based Medicine Tells Us
Chapter 4: Metal Reactivity: Its Influence on Primary and Revision Outcomes
Chapter 5: Are metal ion levels a trigger for surgical intervention?
Chapter 6: Metal Sensitivity: Is it possible to Determine Clinically?
Part III: Biology
Chapter 7: Wound healing, chronic inflammation, and immune responses
Chapter 8: Benign Responses to Orthopaedic Implants: Really?
Chapter 9: What does the Histology Tell Us?
Part IV: Biomechanics
Chapter 10: Why metal-on-metal -what laboratory tests have shown us
Chapter 11: What do the Retrievals really tell us?
Future Directions.

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