Proteins and proteomics of Leishmania and Trypanosoma [electronic resource] / André L.S. Santos, Marta H. Branquinha, Claudia M. d'Avila-Levy, Lucimar F. Kneipp, Cátia L. Sodré, editors.
Santos, Andre L. S., editor of compilation.
2014
QL368.E95
Available Online

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Title Proteins and proteomics of Leishmania and Trypanosoma [electronic resource] / André L.S. Santos, Marta H. Branquinha, Claudia M. d'Avila-Levy, Lucimar F. Kneipp, Cátia L. Sodré, editors.
ISBN 9789400773059 electronic book
9400773056 electronic book
9789400773042
DOI https://doi.org/10.1007/978-94-007-7305-9
Published Dordrecht : Springer, 2014.
Language English
Description 1 online resource (x, 381 pages) : illustrations (some color).
Other Standard Identifiers 10.1007/978-94-007-7305-9 doi
Call Number QL368.E95
Dewey Decimal Classification 616.9/6
Summary This book contains a collection of critical reviews on the expression of biologically functional proteins in Leishmania and Trypanosoma, which was written by renowned researchers on this field. Species belonging to these trypanosomatids genera are etiological agents of leishmaniasis, Chagas' disease and sleeping sickness that are extremely debilitating human infection diseases, which remain a major health problem especially in countries from Latin America, Africa and Middle East. Substantiating the problem, the currently accepted drugs for these diseases are quite unsatisfying due to their low efficacy and high toxicity. In order to solve these real problems, several research groups around the world have become involved in the study and identification of novel potential targets in the trypanosomatid cell. Since proteins are key macromolecules involved in crucial metabolic processes of all living cells, studies have focused on the expression of specific proteins produced by Leishmania and Trypanosoma by means of different biochemical, molecular and proteomic approaches in order to explore them as targets for understanding the parasite life cycle and developing new strategies against trypanosomiasis. With these proposals in mind, the book "Proteins and Proteome of Leishmania and Trypanosoma" encompasses (i) an integrated view about the biochemistry of parasites belonging to the Leishmania and Trypanosoma genera; (ii) an updated review on the expression of biologically relevant proteins by human pathogenic trypanosomatids and their possible role in the interaction with host cells/molecules as well as a target for development of both alternative chemotherapies and vaccine; and (iii) several pictures, diagrams and tables that can be used to illustrate both undergraduate and postgraduate teaching as well as scientific lectures, being a useful resource for students and researchers.
Note Includes index.
Access Note Access limited to authorized users.
Source of Description Description based on online resource; title from PDF title page (SpringerLink, viewed November 25, 2013).
Added Author Santos, Andre L. S., editor of compilation.
Series Sub-cellular biochemistry ; 74. 0306-0225
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Biology of Human Pathogenic Trypanosomatids: Epidemiology, Lifecycle and Ultrastructure
Selection of Molecular Targets for Drug Development against Trypanosomatids
A2 and other visceralizing proteins of Leishmania: role in pathogenesis and application for vaccine development
Arginase in Leishmania
The heat shock proteins of Trypanosoma cruzi
The Gp82 Surface Molecule of Trypanosoma cruzi Metacyclic Forms
The Gp85 Surface Glycoproteins from Trypanosoma cruzi
Trypanosoma cruzi Trans-Sialidase: Structural Features and Biological Implications
Surface Topology Evolution of Trypanosoma Trans-Sialidase
Ecto-Nucleotidases and Ecto-Phosphatases from Leishmania and Trypanosoma Parasites
Gp63 Function in the Interaction of Trypanosomatids with the Invertebrate Host: Facts and Prospects
Highlights on Trypanosomatid Aminoacyl-tRNA Synthesis
The Expected Outcome of the Trypanosoma cruzi Proteomic Map: a Review of its Potential Biological Applications for Drug Target Discovery
Proteomics advances in the study of Leishmania parasites and leishmaniasis
Towards the Phosphoproteome of Trypanosomatids.

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