Angiogenesis and anti-angiogenesis in hematological malignancies. [electronic resource] / Domenico Ribatti.
2014
RC271.N46 R53 2014
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Title
Angiogenesis and anti-angiogenesis in hematological malignancies. [electronic resource] / Domenico Ribatti.
ISBN
9789401780353 electronic book
9401780358 electronic book
9789401780346
9401780358 electronic book
9789401780346
Published
Dordrecht : Springer, [2014]
Copyright
©2014
Language
English
Description
1 online resource : illustrations
Call Number
RC271.N46 R53 2014
Dewey Decimal Classification
616.994061
Summary
It has been generally accepted that angiogenesis is involved in the pathogenesis of hematological malignancies, like acute and chronic leukemia, lymphoma, myelodysplastic syndromes, myeloproliferative neoplasms and multiple myeloma. The extent of angiogenesis in the bone marrow has been correlated with disease burden, prognosis and treatment outcome. Reciprocal positive and negative interactions between tumor cells and bone marrow stromal cells, namely hematopoietic stem cells, fibroblasts, osteoblasts/osteoclasts, endothelial cells, endothelial progenitor cells, T cells, macrophages and mast cells, mediated by an array of cytokines, receptors and adhesion molecules, modulate the angiogenic response in hematological tumors. More recently, it has been emphasized the pro-angiogenic role of the so called "vascular niche", indicating a site rich in blood vessels where endothelial cells and mural cells such as pericytes and smooth muscle cells create a microenvironment that affects the behavior of several stem and progenitor cells, in hematological malignancies.
Bibliography, etc. Note
Includes bibliographical references and index.
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Table of Contents
Introduction
Angiogenesis in Multiple Myeloma
Angiogenesis in Lymphomas
Angiogenesis in Leukemia
Anti-angiogenesis
Concluding Remarks.
Angiogenesis in Multiple Myeloma
Angiogenesis in Lymphomas
Angiogenesis in Leukemia
Anti-angiogenesis
Concluding Remarks.