Next generation sequencing technologies and challenges in sequence assembly [electronic resource] / Sara El-Metwally, Osama M. Ouda, Mohamed Helmy.
El-Metwally, Sara, author.; Ouda, Osama M., author.; Helmy, Mohamed, author.
2014
QH441
Available Online

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Title Next generation sequencing technologies and challenges in sequence assembly [electronic resource] / Sara El-Metwally, Osama M. Ouda, Mohamed Helmy.
Author El-Metwally, Sara, author.
ISBN 9781493907151 electronic book
1493907158 electronic book
9781493907144
DOI https://doi.org/10.1007/978-1-4939-0715-1
Published New York, NY : Springer, 2014.
Language English
Description 1 online resource (xii, 118 pages) : illustrations (some color).
Item Number 10.1007/978-1-4939-0715-1 doi
Call Number QH441
Dewey Decimal Classification 572.8/633
Summary The introduction of Next Generation Sequencing (NGS) technologies resulted in a major transformation in the way scientists extract genetic information from biological systems, revealing limitless insight about the genome, transcriptome and epigenome of any species. However, with NGS, came its own challenges that require continuous development in the sequencing technologies and bioinformatics analysis of the resultant raw data and assembly of the full length genome and transcriptome. Such developments lead to outstanding improvements of the performance and coverage of sequencing and improved quality for the assembled sequences, nevertheless, challenges such as sequencing errors, expensive processing and memory usage for assembly and sequencer specific errors remains major challenges in the field. This book aims to provide brief overviews the NGS field with special focus on the challenges facing the NGS field, including information on different experimental platforms, assembly algorithms and software tools, assembly error correction approaches and the correlated challenges.
Bibliography, etc. Note Includes bibliographical references.
Access Note Access limited to authorized users.
Source of Description Description based on online resource; title from PDF title page (SpringerLink, viewed April 21, 2014).
Added Author Ouda, Osama M., author.
Helmy, Mohamed, author.
Series SpringerBriefs in systems biology ; 7. 2193-4746
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Basics of Molecular Biology for Next-generation Sequencing
Algorithms and Data Structures in Next-generation Sequencing
First- and Next-generations Sequencing Models
Next-generation Sequencing Platforms
Challenges in Next-generation Sequencing Field
New Horizons in Next-generation Sequencing
Novel Next-generation Sequencing Applications
Next-generation Sequence Assembly Overview
Approaches and Challenges of Next-generation Sequence Assembly Stages
Assessment of Next-generation Sequence Assembly
Next-generation Sequence Assemblers
Concluding Remarks.

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