Macrophages [electronic resource] : biology and role in the pathology of diseases / Subhra K. Biswas, Alberto Mantovani, editors.
Biswas, Subhra K., editor.; Mantovani, Alberto, editor.
2014
QR185.8.M3
Available Online

Linked e-resources

Linked Resource
Online Access

Details

Title
Macrophages [electronic resource] : biology and role in the pathology of diseases / Subhra K. Biswas, Alberto Mantovani, editors.
ISBN
9781493913114 electronic book
1493913115 electronic book
9781493913107
1493913107
DOI
https://doi.org/10.1007/978-1-4939-1311-4
Published
New York : Springer, 2014.
Language
English
Description
1 online resource (ix, 615 pages) : illustrations
Item Number
10.1007/978-1-4939-1311-4 doi
Call Number
QR185.8.M3
Dewey Decimal Classification
571.964
Summary
Macrophages are a key component of the innate immune system and play an integral role in host defense and homeostasis. On one hand, these cells contribute to host defence by triggering inflammation, displaying microbicidal/tumoricidal properties, regulating the activation of adaptive immunity and promoting resolution of inflammation. On the other hand, they contribute to essential trophic functions such as neural patterning, bone morphogenesis and ductal branching in mammary glands. Thus, macrophages are extremely versatile cells that can respond efficiently to tissue microenvironmental cues by polarizing to distinct phenotypes, depending on the functions they need to perform. Indeed, functional diversity and plasticity are hallmarks of these cells. Macrophages may also play a detrimental role. An overwhelming body of literature has indicated their crucial role in pathogenesis. The list includes sepsis, cancer, metabolic syndrome, immunodeficiency, auto-immune disease- virtually impacting every major pathology that we know. These observations have suggested macrophages and their related molecules as potential targets in therapeutic applications. Available evidence proclaims macrophages as a key player in homeostasis, host defense and disease. Crucial developments in the past few years call for a re-evaluation and update of our understanding of macrophages. The present book is an endeavour that attempts to provide state-of-the art knowledge of these cells in health and disease.
Access Note
Access limited to authorized users.
Added Author
Biswas, Subhra K., editor.
Mantovani, Alberto, editor.
Available in Other Form
Print version: 9781493913107
Linked Resources
Online Access
Record Appears in
Online Resources > Ebooks
All Resources
Part I Macrophage: Origin, Activation And Polarization
Blood monocytes and their subsets in health and disease
Polarized activation of macrophages
Alternative activation of macrophages: concepts and prospects
Regulatory macrophages and the maintenance of homeostasis
Part II Macrophages And Their Diverse Functions
Phagocytosis
The antimicrobial functions of macrophages
Vascular modulatory functions of macrophages
Part III Macrophages In Different Tissues
Airway macrophages: sentinels of health
Microglial ontogeny and functions in shaping brain circuits
Kupffer cells in health and disease
Intestinal Macrophages: Specialized antigen-presenting cells at the front line
Part IV Macrophages In Pathology
The wound macrophage
Macrophages and the entrance of resolution phase lipid mediators
Macrophages in sepsis progression
Adaptive characteristics of innate immune responses in macrophages
African trypanosomiasis as paradigm for involvement of the mononuclear phagocyte system in pathogenicity during parasite infection
Macrophages in obesity and insulin resistance
Macrophages govern the progression and termination of inflammation in atherosclerosis and metabolic diseases
Myelomonocytic subsets in tumor microenvironment
Tumor associated macrophages
Part V Transcriptional And Epigenetic Mechanisms
Role of NF-kB activation in macrophages
Interferon Regulatory Factors: Role in transcriptional regulation of macrophage plasticity and activation
Kruppel-like factors in Monocyte-Macrophage Biology
Regulation of macrophage polarization by the STAT-SOCS signaling axis
Functions of the large Maf transcription factors and macrophages
The Control of Gene Expression in Macrophages
Role of microRNA in macrophage activation and polarization
Part VI Systems Biology Of Macrophages
The macrophage transcriptome
Omics approaches in macrophage biology
Appendix.

Browse Subjects

Show more subjects...

Statistics

from
to
Export