Genome-based therapeutics [electronic resource] : targeted drug discovery and development : workshop summary / Adam C. Berger and Steve Olson, Rapporteurs ; Roundtable on Translating Genomic-Based Research for Health, Board on Health Sciences Policy, Institute of Medicine of the National Academies.
Berger, Adam C., contributor.; Olson, Steve, 1956- contributor.; Institute of Medicine (U.S.). Roundtable on Translating Genomic-Based Research for Health, issuing body.; Institute of Medicine (U.S.). Board on Health Sciences Policy, issuing body.
2012
RS420 .G4 2012eb
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Title Genome-based therapeutics [electronic resource] : targeted drug discovery and development : workshop summary / Adam C. Berger and Steve Olson, Rapporteurs ; Roundtable on Translating Genomic-Based Research for Health, Board on Health Sciences Policy, Institute of Medicine of the National Academies.
ISBN 9780309260244
0309260248
9780309260213
9780309260251 electronic book
Published Washington, District of Columbia : National Academies Press, [2012]
Copyright ©2012
Language English
Description 1 online resource (109 pages) : illustrations
Call Number RS420 .G4 2012eb
Dewey Decimal Classification 615.1
Summary "The number of new drug approvals has remained reasonably steady for the past 50 years at around 20 to 30 per year, while at the same time the total spending on health-related research and development has tripled since 1990. There are many suspected causes for this trend, including increases in regulatory barriers, the rising costs of scientific inquiry, a decrease in research and development efficiency, the downstream effects of patient expirations on investment, and the lack of production models that have successfully incorporated new technology. Regardless, this trajectory is not economically sustainable for the businesses involved, and, in response, many companies are turning toward collaborative models of drug development, whether with other industrial firms, academia, or government. Introducing greater efficiency and knowledge into these new models and aligning incentives among participants may help to reverse the trends highlighted above, while producing more effective drugs in the process. Genome-based therapeutics explains that new technologies have the potential to open up avenues of development and to identify new drug targets to pursue. Specifically, improved validation of gene-disease associations through genomics research has the potential to revolutionize drug production and lower development costs. Genetic information has helped developers by increasing their understanding of the mechanisms of disease as well as individual patients' reactions to their medications. There is a need to identify the success factors for the various models that are being developed, whether they are industry-led, academia-led, or collaborations between the two. Genome-Based Therapeutics summarizes a workshop that was held on March 21, 2012, titled New paradigms in drug discovery: how genomic data are being used to revolutionize the drug discovery and development process. At this workshop the goal was to examine the general approaches being used to apply successes achieved so far, and the challenges ahead"--Publisher's description.
Bibliography, etc. Note Includes bibliographical references (pages 55-57).
Access Note Access limited to authorized users.
Source of Description Description based on print version record.
Added Author Berger, Adam C., contributor.
Olson, Steve, 1956- contributor.
Added Corporate Author Institute of Medicine (U.S.). Roundtable on Translating Genomic-Based Research for Health, issuing body.
Institute of Medicine (U.S.). Board on Health Sciences Policy, issuing body.
Available in Other Form Genome-based therapeutics : targeted drug discovery and development : workshop summary.
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Introduction
The current landscape
Case studies: The development of Crizotinib for treatment of non-small-cell lung cancer; Use of genetics to inform drug development for the treatment of schizophrenia; A genetic approach to the treatment of cystic fibrosis
Emerging technologies in drug development: Large-scale whole-genome sequencing; The value of clinical next-generation sequencing to drug developers; The uses of genomic information
Evolving paradigms: Foundations and drug development: an example; Genomics and regulatory science; Pharmacy benefit management and pharmacogenomics; Repurposing of drugs
Forging collaborative strategies for the development of personalized medicine: The need for collaboration; FDA initiatives; NCATS initiatives; Biospecimens and databases; Reducing health disparities; Patient and physican education; An emphasis on the science.

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