A systems biology approach to blood [electronic resource] / Seth J. Corey, Marek Kimmel, Joshua N. Leonard, editors.
Corey, Seth J., editor.; Kimmel, Marek, editor.; Leonard, Joshua N., editor.
2014
QP91
Available Online

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Title A systems biology approach to blood [electronic resource] / Seth J. Corey, Marek Kimmel, Joshua N. Leonard, editors.
ISBN 9781493920952 electronic book
1493920952 electronic book
9781493920945
1493920944
DOI https://doi.org/10.1007/978-1-4939-2095-2
Published New York : Springer, [2014]
Copyright ©2014
Language English
Description 1 online resource.
Other Standard Identifiers 10.1007/978-1-4939-2095-2 doi
Call Number QP91
Dewey Decimal Classification 612.11
Summary The blood system is multi-scale, from the organism to the organs to cells to intracellular signaling pathways to macromolecule interactions. Blood consists of circulating cells, cellular fragments (platelets and microparticles), and plasma macromolecules. Blood cells and their fragments result from a highly-ordered process, hematopoiesis. Definitive hematopoiesis occurs in the bone marrow, where pluripotential stem cells give rise to multiple lineages of highly specialized cells. Highly-productive and continuously regenerative, hematopoiesis requires a microenvironment of mesenchymal cells and blood vessels. A Systems Biology Approach to Blood is divided into three main sections: basic components, physiological processes, and clinical applications. Using blood as a window, one can study health and disease through this unique tool box with reactive biological fluids that mirrors the prevailing hemodynamics of the vessel walls and the various blood cell types. Many blood diseases, rare and common can and have been exploited using systems biology approaches with successful results and therefore ideal models for systems medicine. More importantly, hematopoiesis offers one of the best studied systems with insight into stem cell biology, cellular interaction, development; linage programing and reprograming that are every day influenced by the most mature and understood regulatory networks.
Bibliography, etc. Note Includes bibliographical references and index.
Access Note Access limited to authorized users.
Added Author Corey, Seth J., editor.
Kimmel, Marek, editor.
Leonard, Joshua N., editor.
Series Advances in experimental medicine and biology ; volume 844.
Available in Other Form Print version: 9781493920945
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Part I: Basic Components
Systems Hematology: An Introduction
Quantification and Modeling of Stem Cell
Niche Interaction
Angiogenesis: A Systems Biology View of Blood Vessel Remodeling
Erythropoiesis: From Molecular Pathways to System Properties
Systems Biology of Megakaryocytes
Systems Biology of Platelet-Vessel Wall Interactions
Systems Approach to Phagoycte Production and Activation: Neutrophils and Monocytes
Part II: Physiological Processes
Stochasticity and Determinism in Models of Hematopoiesis
Systems Analysis of High?Throughput Data
Developing a Systems-Based Understanding of Hematopoietic Stem Cell Cycle Control
A Systems Biology Approach to Iron Metabolism
Innate Immunity in Disease
Insights from Mathematical Modeling and Analysis
Modeling Biomolecular Site Dynamics in Immunoreceptor Signaling Systems
Structure and Function of Platelet Receptors Initiating Blood Clotting
Part III: Clinical Applications
Understanding and Treating Cytopenia through Mathematical Modeling
Drug Resistance
Etiology and Treatment of Hematological Neoplasms: Stochastic Mathematical Models
Assessing Hematopoietic (Stem-) Cell Behavior during Regenerative Pressure
Engineered Cell-Based Therapies: A Vanguard of Design-Driven Medicine
Part IV: Epilogue
A Systems Approach to Blood Disorders
Index.

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