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Preface; Contents; Contributors; Editor Biographies; Chapter 1: Introduction to℗ Metabonomics in℗ Systems Biology Research; 1.1 Introduction; 1.2 Metabonomics-Based Systems Approaches: Lessons Learnt and℗ Highlights; 1.3 Gut Microbiota Metabolism in℗ Nutrition, Health, and℗ Disease; 1.4 System Biology Approaches: Applications with℗ Specific Reference to℗ Gut Microbial Metabolic Interactions; 1.5 Novel Directions and℗ Perspectives; References; Chapter 2: Metabonomics in℗ Clinical Practice; 2.1 Introduction; 2.2 State-of-the-Art Metabonomics and℗ Lipidomics Technologies
2.3 Metabonomics Flow Chart in℗ Epidemiological Studies2.4 Clinical Applications of℗ Metabonomics for℗ Aging Biomarkers; 2.5 Clinical Application of℗ Metabonomics for℗ Biomarkers of℗ Metabolic Syndrome; 2.6 Clinical Application for℗ Neurological and℗ Psychiatric Disorders; 2.7 Clinical Applications for℗ Cancer Diagnosis; 2.8 Conclusion; References; Chapter 3: Adopting Multivariate Nonparametric Tools to℗ Determine Genotype-Phenotype Interactions in℗ Health and℗ Disease; 3.1 Metabolomics: Introducing the℗ Paradigm Shift in℗ Data Analysis; 3.2 Expanding the℗ View: Machine Learning
3.3 Data Structure and℗ Inference: Classification and℗ Regression Trees (CART)3.4 Ensemble Classifiers: From℗ Single Trees to℗ Random Forests; 3.5 Recent Contributions from℗ RF in℗ the℗ Metabolome-℗ƯMicrobiome Arena; 3.6 Integration Between Information Sources: RF and℗ Networks; 3.7 Application-Driven Improvements to℗ RF Scheme; 3.8 New Challenges to℗ RF:℗ Network Inference; 3.9 Conclusions and℗ Perspective; References; Chapter 4: Metabonomics in℗ Translational Research for℗ Personalized Medicine and℗ Nutrition; 4.1 Metabolomics and℗ Metabonomics; 4.2 Metabonomics: The℗ Link Between Genotypes and℗ Phenotypes
4.3 Role of℗ Pharmacometabonomics in℗ Personalized Medicine4.4 Methodologies Used in℗ Metabonomics; 4.5 Metabonomic Technologies for℗ Toxicology Studies; 4.6 Metabonomics and℗ Personalized Nutrition; 4.7 Gut Microbiota and℗ Phytochemical Profiling in℗ Nutrition Science; 4.8 The Importance of℗ the℗ Gut Microbiota on℗ Metabolic Profiles; 4.9 Conclusion and℗ Future Perspectives; References; Chapter 5: Can We℗ Use Metabolomics to℗ Understand Changes to℗ Gut Microbiota Populations and℗ Function? A℗ Nutritional Perspective; 5.1 Introduction; 5.2 Colonic Digestion; 5.3 Gut Modulation by Foods and℗ Diet
5.3.1 How Do Different Foods Alter Gut Microbiota and℗ Their Metabolism?5.3.2 Microbial Metabolism and℗ a℗ Carbohydrate-Rich Diet; 5.3.3 Fat-Rich Diet Interactions with℗ Gut Microbiota; 5.3.4 Choline Metabolism: An℗ Interaction Node Between Diet, Host, and℗ Gut Microbiota?; 5.3.5 Protein-Rich Diets and℗ Gut Microbiota; 5.3.6 Interaction of℗ a℗ Polyphenol-Rich Diet with℗ the℗ Gut Microbiota; 5.4 Nutritional Metabolomics: A℗ Methodology Well Suited for℗ Understanding the℗ Effects of℗ Food on℗ Gut Microbiota; 5.4.1 Metabolomics Methods to℗ Study Gut Activity Effects on℗ Metabolism; 5.5 Metabolites of℗ Gut Activity
2.3 Metabonomics Flow Chart in℗ Epidemiological Studies2.4 Clinical Applications of℗ Metabonomics for℗ Aging Biomarkers; 2.5 Clinical Application of℗ Metabonomics for℗ Biomarkers of℗ Metabolic Syndrome; 2.6 Clinical Application for℗ Neurological and℗ Psychiatric Disorders; 2.7 Clinical Applications for℗ Cancer Diagnosis; 2.8 Conclusion; References; Chapter 3: Adopting Multivariate Nonparametric Tools to℗ Determine Genotype-Phenotype Interactions in℗ Health and℗ Disease; 3.1 Metabolomics: Introducing the℗ Paradigm Shift in℗ Data Analysis; 3.2 Expanding the℗ View: Machine Learning
3.3 Data Structure and℗ Inference: Classification and℗ Regression Trees (CART)3.4 Ensemble Classifiers: From℗ Single Trees to℗ Random Forests; 3.5 Recent Contributions from℗ RF in℗ the℗ Metabolome-℗ƯMicrobiome Arena; 3.6 Integration Between Information Sources: RF and℗ Networks; 3.7 Application-Driven Improvements to℗ RF Scheme; 3.8 New Challenges to℗ RF:℗ Network Inference; 3.9 Conclusions and℗ Perspective; References; Chapter 4: Metabonomics in℗ Translational Research for℗ Personalized Medicine and℗ Nutrition; 4.1 Metabolomics and℗ Metabonomics; 4.2 Metabonomics: The℗ Link Between Genotypes and℗ Phenotypes
4.3 Role of℗ Pharmacometabonomics in℗ Personalized Medicine4.4 Methodologies Used in℗ Metabonomics; 4.5 Metabonomic Technologies for℗ Toxicology Studies; 4.6 Metabonomics and℗ Personalized Nutrition; 4.7 Gut Microbiota and℗ Phytochemical Profiling in℗ Nutrition Science; 4.8 The Importance of℗ the℗ Gut Microbiota on℗ Metabolic Profiles; 4.9 Conclusion and℗ Future Perspectives; References; Chapter 5: Can We℗ Use Metabolomics to℗ Understand Changes to℗ Gut Microbiota Populations and℗ Function? A℗ Nutritional Perspective; 5.1 Introduction; 5.2 Colonic Digestion; 5.3 Gut Modulation by Foods and℗ Diet
5.3.1 How Do Different Foods Alter Gut Microbiota and℗ Their Metabolism?5.3.2 Microbial Metabolism and℗ a℗ Carbohydrate-Rich Diet; 5.3.3 Fat-Rich Diet Interactions with℗ Gut Microbiota; 5.3.4 Choline Metabolism: An℗ Interaction Node Between Diet, Host, and℗ Gut Microbiota?; 5.3.5 Protein-Rich Diets and℗ Gut Microbiota; 5.3.6 Interaction of℗ a℗ Polyphenol-Rich Diet with℗ the℗ Gut Microbiota; 5.4 Nutritional Metabolomics: A℗ Methodology Well Suited for℗ Understanding the℗ Effects of℗ Food on℗ Gut Microbiota; 5.4.1 Metabolomics Methods to℗ Study Gut Activity Effects on℗ Metabolism; 5.5 Metabolites of℗ Gut Activity