Preface; Contents; Contributors; Chapter 1: Introduction; References; Chapter 2: Alcohol and Breast Cancer: Reconciling Epidemiological and Molecular Data; 2.1 Introduction; 2.2 The Biology of Breast Cancer; 2.3 Known Risk Factors for Breast Cancer; 2.4 Alcohol as a Risk Factor for Breast Cancer; 2.4.1 Epidemiological Studies; 2.4.2 Molecular Studies; 2.4.2.1 Estrogen Metabolism; 2.4.2.2 Alcohol Metabolism; 2.4.2.3 Folate Metabolism/Epigenetic Factors; 2.5 Concluding Remarks; 2.5.1 Multiple Risk Factors; 2.5.2 Epidemiological Studies

2.5.3 Discrepancies Between Epidemiological and Molecular StudiesReferences; Chapter 3: Genetic-Epidemiological Evidence for the Role of Acetaldehyde in Cancers Related to Alcohol Drinking; 3.1 Introduction; 3.2 General Evidence for the Carcinogenicity of Acetaldehyde; 3.3 Genetic-Epidemiological Evidence for the Carcinogenicity of Acetaldehyde; 3.3.1 Basic Difficulties in Assessing the Genetic-Epidemiological Evidence; 3.3.2 Upper Aerodigestive Tract Cancer; 3.3.3 Gastric Cancer; 3.3.4 Colorectal Cancer; 3.3.5 Pancreatic Cancer; 3.3.6 Liver Cancer; 3.3.7 Lung Cancer; 3.3.8 Breast Cancers

3.4 Summary and ConclusionsReferences; Chapter 4: Alcohol and Cancer: An Overview with Special Emphasis on the Role of Acetaldehyde and Cytochrome P450 2E1; 4.1 Introduction; 4.1.1 Historic Background; 4.1.2 Epidemiology and Animal Experiments; 4.2 Specific Mechanisms of Ethanol-Mediated Carcinogenesis; 4.2.1 Acetaldehyde as a Carcinogen; 4.2.1.1 Mechanisms; 4.2.1.2 Genetic Aspects of Acetaldehyde Accumulation; 4.2.2 Alcohol and Oxidative Stress; 4.2.2.1 Mechanisms of ROS and Cytochrome P450 2E1 in Alcohol-Mediated Carcinogenesis; 4.2.2.2 The Role of CYP2E1 in Experimental Carcinogenesis

4.3 CYP2E1 and Its Role in Nonalcoholic Fatty Liver DiseasesReferences; Chapter 5: Implications of Acetaldehyde-Derived DNA Adducts for Understanding Alcohol-Related Carcinogenesis; 5.1 Introduction; 5.2 DNA Adducts from Acetaldehyde and Alcohol; 5.2.1 Other Acetaldehyde-DNA Adducts; 5.3 N2-Ethylidene-dG as a Biomarker of DNA Damage Resulting from Acetaldehyde Derived from Ethanol; 5.3.1 Experimental Studies of Acetaldehyde-DNA Adduct Formation from Alcohol Drinking in Humans; 5.3.2 Anatomical Considerations

5.4 Why Are ALDH2-Deficient Individuals at Such Elevated Risk of Esophageal Cancer from Drinking Alcohol?5.5 Is There a "Carcinogenic" Level of Acetaldehyde?; 5.6 Summary and Conclusions; References; Chapter 6: The Role of Iron in Alcohol-Mediated Hepatocarcinogenesis; 6.1 Introduction; 6.2 Health Statistics of ALD; 6.3 Prevalence of Iron Overload in ALD; 6.4 Iron Toxicity and Carcinogenesis; 6.5 Mechanism of Iron Overload; 6.6 Systemic Regulation; 6.7 Cellular Iron Regulation; 6.8 Redox Regulation of Iron Metabolism; 6.9 Non-hepatic Causes of Alcohol-Mediated Iron Overload