Foreword to Comprehensive Treatmentof Chronic Pain by Medical, Interventional,and Integrative Approaches; Foreword to Comprehensive Treatmentof Chronic Pain by Medical, Interventional,and Integrative Approaches; Preface to Treatment of Chronic Pain by Medical Approaches; Preface to Comprehensive Treatment of Chronic Pain by Medical, Interventional, and Integrative Approaches; Contents; Contributors; 1: A Survey of Systems Involved in Nociceptive Processing; Key Points; Background; Overview of the Psychophysics of Nociception; Acute Stimulation; Tissue Injury; Nerve Injury

Encoding of Acute NociceptionTransduction Channels and Afferent Terminal Activation; Chemical Sensitivity of Temperature Channels; Action Potential Generation; Encoding Properties of Primary Afferents; Afferent Synaptic Transmission; Calcium Channels and Afferent Transmitter Release; Spinal Afferent Terminal Transmitters; Laminar Organization of Spinal Dorsal Horn; Primary Afferent Projections; Dorsal Horn Neurons; Dorsal Horn Projections; Supraspinal Organization; Encoding of Nociception After Tissue Injury; Peripheral Changes in Afferent Transmission Resulting from Tissue

Origin of Ongoing Activity and Enhanced Terminal Responsiveness After Tissue Injury Spinal Changes in Afferent Transmission Resulting from Tissue Injury; Central (Spinal) Facilitation; Enhanced Response of WDR Neuron; Pharmacology of Central Facilitation; Primary Afferents; Postsynaptic to the Primary Afferents; Local Interneuronal Networks; Bulbospinal Systems; Nonneuronal Cells; Evolution of a Chronic Pain State After Acute Injury; Summary; Encoding of Nociception After Nerve Injury; Events Initiated by Nerve Injury; Origins of Spontaneous Pain State

Site of Origin of Spontaneous Afferent Traffic Mechanisms of Ongoing Activity; Increased Sodium Channel Expression; Decreased K Channel Expression; Inflammatory Products; Origins of Evoke Hyperpathia; Dorsal Root Ganglion Cell Cross Talk; Afferent Sprouting; Loss of Intrinsic GABAergic/Glycinergic Inhibitory Control; Nonneuronal Cells and Nerve Injury; Sympathetic Dependency; Generalization to Many Nerve Injury Pain States; Conclusions; References; 2: Pharmacogenomics of Pain Management; Key Points; Introduction; Background; Functional Genomics of Pain

Pharmacogenomics of Pain Therapy and Its Usefulness in Clinical Practice Genetic Variations in the Prodrug Activation; Genetic Variations in the Elimination of Analgesic Drugs; Genetic Variations in the Transmembrane Transport of Analgesics; Pharmacodynamics of Pain Therapy; Opioid Receptors; Catechol-O-Methyltransferase (COMT); Melanocortin 1 Receptor (MC1R); Cyclooxygenases (COX); Future Direction of Pharmacogenomics in Pain Treatment; Summary; References; 3: Nonsteroidal Anti-inflammatory Drugs; Key Points; Introduction; Mechanism of Action; Pharmacokinetics; Absorption.