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Contributors; Part I; Editor's Introduction: Skin Lipids; Chapter 1; Skin Lipids: An Introduction and Their Importance; Part II; Skin Basics; Chapter 2; Skin Basics Structure and Function; Introduction; Functional Aspects of Skin in Health; Structural Organization of the Mammalian Skin; Epidermis; Diverse and Interdependent Barriers in Epidermis; The Dermal-Epidermal Junction (DEJ) or the Basement Membrane Zone (BMZ); The Dermis; Collagen; Elastin; Glycosaminoglycans (GAG); Fibroblasts; Other Components; Skin Appendages; Hypodermis; Summary of Skin Functions; References; Chapter 3
Skin Barrier, Structure, and PropertiesIntroduction; History; Skin Lipid Composition and Phase State; Molecular Structure Determination Directly In Situ; The Procedure; CEMOVIS; Modeling and Simulation of the Horny Layer Lipid organization; Skin Lipid Structure; Skin Lipid Formation; Skin Lipid Function; Summary; References; Chapter 4; Polyunsaturated Fatty Acid Oxygenated Metabolites in Skin; Introduction; Cyclooxygenase-Derived Lipid Mediators; Lipoxygenase-Derived Lipid Mediators; Cytochrome P450-Derived Lipid Mediators; Non-enzymatically Produced Oxidised Lipid Mediators
Bioactivities of Oxidised Lipid Mediators and Role in Inflammatory Skin DiseaseBioactivity of Cutaneous Prostanoids; Bioactivity of Cutaneous Hydroxy and Epoxy Fatty Acids; References; Part III; Epidermal Lipids; Chapter 5; Skin Ceramides; Introduction; Biosynthetic Pathways; Structures, Proportions, and Properties; Catabolism; References; Chapter 6; Cholesterol Metabolism in the Epidermis; Introduction; Unraveling the Significance of Cholesterol for Skin Permeability Barrier Function; Effects of Aging; Cholesterol Sulfate; Role of Cholesterol Sulfate in Keratinocyte Differentiation
Steroid SulfataseRole of Cholesterol Sulfate in Desquamation; Role of Cholesterol Sulfate in Permeability Function; Conclusion; References; Chapter 7; Nuclear Hormone Receptors and Epidermal Differentiation; Introduction; Keratinocyte Differentiation; Transcriptional Regulation of Keratinocyte Differentiation: Nuclear Hormone Receptors; Vitamin D Receptor (VDR); Retinoic Acid Receptors (RARs) and Retinoid X Receptors (RXRs); Peroxisome Proliferator-Activated Receptors (PPARs); Additional Remarks; Summary; References; Part IV; Sebaceous Lipids; Chapter 8; The Brain of the Skin: Sebaceous Gland
Introduction: The Birth of NeurodermatologyHormone Receptors in Human Sebaceous Glands and Their Biological Activity; Peptide Hormone and Neurotransmitter Receptors; Nuclear Receptors; Activation of the HPA-Like Skin Axis in Sebaceous Glands; Androgens and Sebaceous Gland Development, Cell Differentiation, and Lipogenesis; Signaling and Metabolic Pathways Operative in Hormonally Aged Sebocytes In Vitro; Conclusions; References; Chapter 9; Sebaceous Lipids; Introduction; Sebaceous Lipids and Their Uniqueness; a) Sapienic Acid; b) Wax Esters; c) Squalene
Skin Barrier, Structure, and PropertiesIntroduction; History; Skin Lipid Composition and Phase State; Molecular Structure Determination Directly In Situ; The Procedure; CEMOVIS; Modeling and Simulation of the Horny Layer Lipid organization; Skin Lipid Structure; Skin Lipid Formation; Skin Lipid Function; Summary; References; Chapter 4; Polyunsaturated Fatty Acid Oxygenated Metabolites in Skin; Introduction; Cyclooxygenase-Derived Lipid Mediators; Lipoxygenase-Derived Lipid Mediators; Cytochrome P450-Derived Lipid Mediators; Non-enzymatically Produced Oxidised Lipid Mediators
Bioactivities of Oxidised Lipid Mediators and Role in Inflammatory Skin DiseaseBioactivity of Cutaneous Prostanoids; Bioactivity of Cutaneous Hydroxy and Epoxy Fatty Acids; References; Part III; Epidermal Lipids; Chapter 5; Skin Ceramides; Introduction; Biosynthetic Pathways; Structures, Proportions, and Properties; Catabolism; References; Chapter 6; Cholesterol Metabolism in the Epidermis; Introduction; Unraveling the Significance of Cholesterol for Skin Permeability Barrier Function; Effects of Aging; Cholesterol Sulfate; Role of Cholesterol Sulfate in Keratinocyte Differentiation
Steroid SulfataseRole of Cholesterol Sulfate in Desquamation; Role of Cholesterol Sulfate in Permeability Function; Conclusion; References; Chapter 7; Nuclear Hormone Receptors and Epidermal Differentiation; Introduction; Keratinocyte Differentiation; Transcriptional Regulation of Keratinocyte Differentiation: Nuclear Hormone Receptors; Vitamin D Receptor (VDR); Retinoic Acid Receptors (RARs) and Retinoid X Receptors (RXRs); Peroxisome Proliferator-Activated Receptors (PPARs); Additional Remarks; Summary; References; Part IV; Sebaceous Lipids; Chapter 8; The Brain of the Skin: Sebaceous Gland
Introduction: The Birth of NeurodermatologyHormone Receptors in Human Sebaceous Glands and Their Biological Activity; Peptide Hormone and Neurotransmitter Receptors; Nuclear Receptors; Activation of the HPA-Like Skin Axis in Sebaceous Glands; Androgens and Sebaceous Gland Development, Cell Differentiation, and Lipogenesis; Signaling and Metabolic Pathways Operative in Hormonally Aged Sebocytes In Vitro; Conclusions; References; Chapter 9; Sebaceous Lipids; Introduction; Sebaceous Lipids and Their Uniqueness; a) Sapienic Acid; b) Wax Esters; c) Squalene