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Preface; Contents; Chapter 1: Human-Specific Evolutionary Changes in the Biology of Siglecs; Introduction; Human-Specific Changes in Siglecs; Siglec-1/Sialoadhesin; Siglec-3/CD33; Siglec-5 and -14; Siglec-6; Siglec-9; Siglec-11 and -16; Siglec-XII; Siglec-13; Siglec-17; Conclusions and Perspectives; References; Chapter 2: Structural Changes of GPI Anchor After Its Attachment to Proteins: Functional Significance; Introduction; Biosynthesis of GPI and Its Attachment to Proteins; GPI Remodeling Reactions That Occur After Attachment to Proteins; Inositol-Deacylation by PGAP1 in the ER
Removal of an EtNP Side Branch from the Second Mannose by PGAP5 in the ER Fatty Acid Remodeling of GPI-AP in the Golgi; Biological Significance of Fatty Acid Remodeling; References; Chapter 3: Novel Insights in Membrane Biology Utilizing Fluorescence Recovery After Photobleaching; The Dynamic Membrane; Fluorescence Recovery After Photobleaching; Lipid Dynamics by FRAP; GPCR Activation: Manifestations in Receptor Dynamics; Dynamic Confinement of GPCRs Upon Cholesterol Depletion: Insight from Bleach Area-Dependent FRAP; Are Signaling and Dynamics Correlated?
Lateral Dynamics as Readout of Infection Conclusion and Future Perspectives; References; Chapter 4: Defects in Erythrocyte Membrane Skeletal Architecture; Introduction; Membrane Skeleton; Erythroid Membrane Skeleton; Lipid Bilayer: Membrane Skeleton Interactions; Assembly of the Membrane-Skeleton of Erythroid Cells; Defects in Membrane Skeleton; Hereditary Spherocytosis; Molecular Defects in HS; Pathophysiology; Laboratory Features and Treatment; Hereditary Elliptocytosis; Molecular Defects in HE; Laboratory Features and Treatment; Malaria and the Erythrocyte Membrane Skeleton Alterations
ConclusionReferences; Chapter 5: Membrane Rafts in the Erythrocyte Membrane: A Novel Role of MPP1p55; Introduction; Erythrocyte Membrane Rafts; Stomatin, Flotillins and MPP1 Are the Stable Components of Erythrocyte Rafts; Stomatin; Flotillins; MPP1; Visualization of Erythrocyte Membrane Rafts; Role of Erythrocyte Membrane Rafts in Signaling; Erythrocyte Rafts and Pathology; MPP1 and Its Palmitoylation Play a Crucial Role in Lateral Membrane Organization in Erythroid Cells; The Involvement of Actin in Erythrocyte Membrane Rafts Organization?; Conclusions; References
Chapter 6: Immuno-Modulatory Role of Porins: Host Immune Responses, Signaling Mechanisms and Vaccine PotentialIntroduction; Role of Porins in Modulation of Immune Responses; Innate Immune Responses; Adaptive Immune Response; Signaling Cascades Initiated by Porins; Porins as Vaccine Candidates; Conclusion; References; Chapter 7: Vibrio cholerae Cytolysin: Structure-Function Mechanism of an Atypical β-Barrel Pore-Forming Toxin; Introduction; Vibrio cholerae Cytolysin; Structural Features of VCC; Structural Features of the VCC β-Barrel Pore; Mechanism of Membrane Pore Formation; Conclusion
Removal of an EtNP Side Branch from the Second Mannose by PGAP5 in the ER Fatty Acid Remodeling of GPI-AP in the Golgi; Biological Significance of Fatty Acid Remodeling; References; Chapter 3: Novel Insights in Membrane Biology Utilizing Fluorescence Recovery After Photobleaching; The Dynamic Membrane; Fluorescence Recovery After Photobleaching; Lipid Dynamics by FRAP; GPCR Activation: Manifestations in Receptor Dynamics; Dynamic Confinement of GPCRs Upon Cholesterol Depletion: Insight from Bleach Area-Dependent FRAP; Are Signaling and Dynamics Correlated?
Lateral Dynamics as Readout of Infection Conclusion and Future Perspectives; References; Chapter 4: Defects in Erythrocyte Membrane Skeletal Architecture; Introduction; Membrane Skeleton; Erythroid Membrane Skeleton; Lipid Bilayer: Membrane Skeleton Interactions; Assembly of the Membrane-Skeleton of Erythroid Cells; Defects in Membrane Skeleton; Hereditary Spherocytosis; Molecular Defects in HS; Pathophysiology; Laboratory Features and Treatment; Hereditary Elliptocytosis; Molecular Defects in HE; Laboratory Features and Treatment; Malaria and the Erythrocyte Membrane Skeleton Alterations
ConclusionReferences; Chapter 5: Membrane Rafts in the Erythrocyte Membrane: A Novel Role of MPP1p55; Introduction; Erythrocyte Membrane Rafts; Stomatin, Flotillins and MPP1 Are the Stable Components of Erythrocyte Rafts; Stomatin; Flotillins; MPP1; Visualization of Erythrocyte Membrane Rafts; Role of Erythrocyte Membrane Rafts in Signaling; Erythrocyte Rafts and Pathology; MPP1 and Its Palmitoylation Play a Crucial Role in Lateral Membrane Organization in Erythroid Cells; The Involvement of Actin in Erythrocyte Membrane Rafts Organization?; Conclusions; References
Chapter 6: Immuno-Modulatory Role of Porins: Host Immune Responses, Signaling Mechanisms and Vaccine PotentialIntroduction; Role of Porins in Modulation of Immune Responses; Innate Immune Responses; Adaptive Immune Response; Signaling Cascades Initiated by Porins; Porins as Vaccine Candidates; Conclusion; References; Chapter 7: Vibrio cholerae Cytolysin: Structure-Function Mechanism of an Atypical β-Barrel Pore-Forming Toxin; Introduction; Vibrio cholerae Cytolysin; Structural Features of VCC; Structural Features of the VCC β-Barrel Pore; Mechanism of Membrane Pore Formation; Conclusion