Polyamines [electronic resource] : a universal molecular nexus for growth, survival, and specialized metabolism / Tomonobu Kusano, Hideyuki Suzuki, editors.
Kusano, Tomonobu, editor.; Suzuki, Hideyuki, editor.
2015
QP801.P638 P65 2015eb
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Title
Polyamines [electronic resource] : a universal molecular nexus for growth, survival, and specialized metabolism / Tomonobu Kusano, Hideyuki Suzuki, editors.
ISBN
9784431552123 electronic book
443155212X electronic book
9784431552116
DOI
https://doi.org/10.1007/978-4-431-55212-3
Published
Tokyo : Springer, 2015.
Language
English
Description
1 online resource (ix, 336 pages) : illustrations.
Item Number
10.1007/978-4-431-55212-3 doi
Call Number
QP801.P638 P65 2015eb
Dewey Decimal Classification
572/.548
Summary
This book covers key topics in polyamine research from a range of organisms, including plants, mammals, and prokaryotes such as bacteria and archaea. The book provides an introduction to general concepts in the field of polyamine research, as well as more detailed information. With the availability of genome sequence data from a broad range of organisms, the evolution of the genes involved in polyamine metabolism is discussed. The mode of action of polyamines has been shown to be dependent on cation channels, and this mechanism is described in the book. The origin of polyamine transporters (from bacteria, yeasts, and plants) is described. The various effects of polyamines on growth and survival are also documented. The book details the mechanisms of polyamine homeostasis and the role of polyamine molecules as precursors of secondary metabolites such as plant alkaloids and toxins derived from spiders and wasps. The role of polyamines in longevity and disease is discussed. A link between polyamine contents and cancer progression is reported, as is the use of polyamine metabolites as diagnostic markers in the initial stages of cancer. Moreover, a novel approach that utilizes the polyamine pathway of a parasite as a drug target in African sleeping sickness is described. Therefore, this book is a valuable resource, both as a textbook for undergraduate and graduate students and also as a reference book for front-line polyamine researchers.
Note
Includes index.
Bibliography, etc. Note
Includes bibliographical references and index.
Access Note
Access limited to authorized users.
Source of Description
Online resource; title from PDF title page (SpringerLink, viewed January 26, 2015).
Added Author
Kusano, Tomonobu, editor.
Suzuki, Hideyuki, editor.
Available in Other Form
Print version: 9784431552116
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PART I BIOSYNTHESIS OF POLYAMINES,- 1 Biosynthesis of Polyamines in Eukaryotes, Archaea, and Bacteria
2 Long-Chain and Branched Polyamines in Thermophilic Microbes
3 Regulation and Diversity of Polyamine Biosynthesis in Plants
PART II CATABOLISM OF POLYAMINES
4 Polyamine Catabolism in Prokaryotes
5 Mammalian Polyamine Catabolism
6 Polyamine Catabolism in Plants
PART III POLYAMINE HOMEOSTASIS
7 Antizyme
8 Bacterial Antizyme
9 Polyamine Homeostasis in Plants: The Role(s) of Evolutionarily Conserved Upstream ORFs
PART IV ROLES OF POLYAMINES IN GROWTH
10 Role of the Polyamine Spermidine as a Precursor for Hypusine Modification in eIF5A
11 The Polyamine Modulon: Genes Encoding Proteins Whose Synthesis Is Enhanced by Polyamines at the Level of Translation
12 Protein Synthesis and Polyamines in Thermophiles: Effect of Polyamines on Nucleic Acid Maintenance and Gene Expression
PART V ROLES OF POLYAMINES IN SURVIVAL
13 Polyamines in Plant Stress Response
PART VI POLYAMINE TRANSPORTERS
14 Recent Advances in Bacterial Polyamine Transport Systems
15 Polyamine Transport Systems in Plants
PART VII POLYAMINE-DERIVED SECONDARY METABOLITES
16 Polyamine-Derived Alkaloids in Plants: Molecular Elucidation of Biosynthesis
17 Polyamine Toxins from Spiders and Wasps
PART VIII ACTION OF POLYAMINES ON ION CHANNELS
18 Polyamine Block of Inwardly Rectifying Potassium (Kir) Channels
19 Polyamine Action on Plant Ion Channels and Pumps
20 Regulation of N-Methyl-d-Aspartate Receptors by Spermine and Ifenprodil
PART IX POLYAMINES AND LONGEVITY
21 Polyamines and Longevity in Mammals
22 Polyamine Interactions with Plant Hormones: Crosstalk at Several Levels
PART X DIAGNOSIS AND DRUG TARGETS
23 N1, N12-Diacetylspermine in Human Urine: Performance as a Tumor Marker, Quantification, Production, and Excretion
24 Targeting the Polyamine Biosynthetic Pathway in Parasitic Protozoa.

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