Surface-enhanced raman spectroscopy [electronic resource] : bioanalytical, biomolecular and medical applications / Marek Procházka.
Procházka, Marek, author.
2016
QD96.R34
Available Online

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Title Surface-enhanced raman spectroscopy [electronic resource] : bioanalytical, biomolecular and medical applications / Marek Procházka.
Author Procházka, Marek, author.
ISBN 9783319239927 (electronic book)
3319239929 (electronic book)
9783319239903
DOI https://doi.org/10.1007/978-3-319-23992-7
Published Cham : Springer, 2016.
Language English
Description 1 online resource : chiefly color illustrations.
Item Number 10.1007/978-3-319-23992-7 doi
Call Number QD96.R34
Dewey Decimal Classification 543.57
Summary This book gives an overview of recent developments in RS and SERS for sensing and biosensing considering also limitations, possibilities and prospects of this technique. Raman scattering (RS) is a widely used vibrational technique providing highly specific molecular spectral patterns. A severe limitation for the application of this spectroscopic technique lies in the low cross section of RS. Surface-enhanced Raman scattering (SERS) spectroscopy overcomes this problem by 6-11 orders of magnitude enhancement compared with the standard RS for molecules in the close vicinity of certain rough metal surfaces. Thus, SERS combines molecular fingerprint specificity with potential single-molecule sensitivity. Due to the recent development of new SERS-active substrates, labeling and derivatization chemistry as well as new instrumentations, SERS became a very promising tool for many varied applications, including bioanalytical studies and sensing. Both intrinsic and extrinsic SERS biosensing schemes have been employed to detect and identify small molecules, nucleic acids and proteins, and also for cellular and in vivo sensing.
Bibliography, etc. Note Includes bibliographical references and index.
Access Note Access limited to authorized users.
Source of Description Online resource; title from PDF title page (viewed December 17, 2015).
Series Biological and medical physics, biomedical engineering.
Available in Other Form Print version: 9783319239903
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Preface; Contents; Acronyms; 1 Introduction; References; 2 Basics of Raman Scattering (RS) Spectroscopy; Abstract; 2.1 Short History of Raman Effect; 2.2 Basic Theory of RS; 2.3 Molecular Vibrations and Their Raman Activity; 2.4 Raman Experiment; 2.5 Raman Spectroscopy for Biomolecular Studies; 3 Basics of Surface-Enhanced Raman Scattering (SERS); Abstract; 3.1 SERS Mechanisms; 3.1.1 EM Mechanism of SERS; 3.1.2 Chemical (Molecular) Mechanism of SERS; 3.2 SERS EFs; 3.3 SM-SERS; 3.4 SERS-Active Substrates; 3.4.1 Metallic NP Hydrosols.

3.4.2 NPs and Nanostructures on Planar Supports Prepared by Bottom-Up Techniques3.4.2.1 NPs Self-assembled in Planar Supports; 3.4.2.2 Metallic NR Arrays Prepared by Angle Vapour Deposition; 3.4.3 Nanostructures Fabricated Using Nanolithographic (Top-Down) Techniques; 3.4.3.1 Electron Beam Lithography (EBL) and Ion Beam Lithography (IBL); 3.4.3.2 Nanoimprint Lithography (NIL); 3.4.4 Highly Ordered Metallic Nanostructures Fabricated by Template Techniques; 3.4.4.1 Nanosphere Lithography (NSL); 3.4.4.2 ``Hole Mask'' Colloidal Lithography (HCL); 3.4.4.3 Electrochemical Depositions.

3.4.5 Commercially Available Substrates3.5 Practical Aspects of SERS; 3.6 Related Enhanced Techniques; References; 4 Bioanalytical SERS Applications; Abstract; 4.1 Quantitative SERS Methods; 4.1.1 SERS-Active Substrates for Quantitative SERS; 4.1.2 Internal Intensity Standards for Quantitative SERS; 4.1.3 Sensitivity and Specificity of SERS Sensor; 4.2 SERS Sensing of Pharmaceuticals and Drugs; 4.2.1 SERS Sensing of Pharmaceuticals; 4.2.2 SERS Sensing of Drugs; 4.3 SERS Sensing of Pollutants, Food Contaminants and Food Additives; 4.3.1 SERS Sensing of Pollutants and Pesticides.

4.3.2 SERS Sensing of Melamine4.3.3 SERS Sensing of Food Colourants; 4.4 SERS Identification of Biowarfare Agent Anthrax; References; 5 Biomolecular SERS Applications; Abstract; 5.1 SERS Biomolecular Detection Schemes; 5.2 Nucleic Acids (NAs) and Their Components; 5.2.1 Intrinsic Detection of NAs; 5.2.2 Intrinsic NA Detection Using Hybridization; 5.2.3 Intrinsic NA Detection Using TERS; 5.2.4 Extrinsic Detection of NAs; 5.2.5 Extrinsic NA Detection Using Hybridization; 5.3 Proteins and Their Components; 5.3.1 Intrinsic Detection of Proteins; 5.3.2 Extrinsic Detection of Proteins.

5.3.3 Immunoassays5.4 Lipids and Membranes; References; 6 SERS Investigations of Cells, Viruses and Microorganisms; Abstract; 6.1 Intracellular SERS Investigations; 6.1.1 Intracellular SERS Detection Strategies; 6.1.2 Delivery of the Metallic NPs Inside the Cells; 6.1.3 Chemical Probing in Cells by Intrinsic SERS Spectra; 6.1.4 Chemical Probing in Cells Using SERS Tags with RRMs; 6.1.5 Endosomal pH Monitored by SERS; 6.1.6 Intracellular SERS Using Tip-like Substrates; 6.1.7 Experimental Aspects of Intracellular SERS Studies; 6.2 Detection and Identification of Viruses and Microorganisms.

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