DNA replication, recombination, and repair [electronic resource] : molecular mechanisms and pathology / Fumio Hanaoka, Kaoru Sugasawa, editors.
Hanaoka, Fumio, 1946- editor.; Sugasawa, Kaoru, editor.
2016
QP624
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Title DNA replication, recombination, and repair [electronic resource] : molecular mechanisms and pathology / Fumio Hanaoka, Kaoru Sugasawa, editors.
ISBN 9784431558736 (electronic book)
443155873X (electronic book)
9784431558712
DOI https://doi.org/10.1007/978-4-431-55873-6
Published Tokyo : Springer, 2016.
Language English
Description 1 online resource (ix, 555 pages) : illustrations.
Item Number 10.1007/978-4-431-55873-6 doi
Call Number QP624
Dewey Decimal Classification 572.8/645
Summary This book is a comprehensive review of the detailed molecular mechanisms of and functional crosstalk among the replication, recombination, and repair of DNA (collectively called the "3Rs") and the related processes, with special consciousness of their biological and clinical consequences. The 3Rs are fundamental molecular mechanisms for organisms to maintain and sometimes intentionally alter genetic information. DNA replication, recombination, and repair, individually, have been important subjects of molecular biology since its emergence, but we have recently become aware that the 3Rs are actually much more intimately related to one another than we used to realize. Furthermore, the 3R research fields have been growing even more interdisciplinary, with better understanding of molecular mechanisms underlying other important processes, such as chromosome structures and functions, cell cycle and checkpoints, transcriptional and epigenetic regulation, and so on. This book comprises 7 parts and 21 chapters: Part 1 (Chapters 1-3), DNA Replication; Part 2 (Chapters 4-6), DNA Recombination; Part 3 (Chapters 7-9), DNA Repair; Part 4 (Chapters 10-13), Genome Instability and Mutagenesis; Part 5 (Chapters 14-15), Chromosome Dynamics and Functions; Part 6 (Chapters 16-18), Cell Cycle and Checkpoints; Part 7 (Chapters 19-21), Interplay with Transcription and Epigenetic Regulation. This volume should attract the great interest of graduate students, postdoctoral fellows, and senior scientists in broad research fields of basic molecular biology, not only the core 3Rs, but also the various related fields (chromosome, cell cycle, transcription, epigenetics, and similar areas). Additionally, researchers in neurological sciences, developmental biology, immunology, evolutionary biology, and many other fields will find this book valuable.
Note Includes index.
Access Note Access limited to authorized users.
Source of Description Online resource; title from PDF title page (SpringerLink, viewed January 27, 2016).
Added Author Hanaoka, Fumio, 1946- editor.
Sugasawa, Kaoru, editor.
Available in Other Form Print version: 9784431558712
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Part 1 DNA Replication
1 Molecular Mechanism of DNA Replication
2 Characteristics of Metazoan DNA Replication Origins
3 DNA Replication Timing: Temporal and Spatial Regulation of Eukaryotic DNA Replication
Part 2 DNA Recombination
4 Mechanism of Homologous Recombination
5 Regulation of Recombination by Chromatin
6 Homologous Recombination During Meiosis
Part 3 DNA Repair
7 DNA Damage Recognition and Repair in Mammalian Global Genome Nucleotide Excision Repair
8 The Fanconi Anemia Pathway and Interstrand Crosslink Repair
9 The Crossroads of Ubiquitination and DNA Repair: A Structural Perspective
Part 4 Genome Instability and Mutagenesis
10 Genome Instability of Repetitive Sequence: Lesson From the Ribosomal RNA Gene Repeat
11 Translesion DNA Synthesis and Damage Tolerance Pathways
12 Mismatch Repair
13 Non-Homologous End-Joining
Part 5 Chromosome Dynamics and Functions
14 Centromeric Chromatin and Kinetochore Assembly in Vertebrate Cells
15 CST Complex and Telomere Maintenance
Part 6 Cell Cycle and Checkpoints
16 Signaling of DNA Replication Stress Through the ATR Checkpoint
17 Spindle Assembly Checkpoint: Its Control and Aberration
18 Molecular Insights Into the Regulation of Apoptosis and Cellular Senescence and Their Implications for Cancer
Part 7 Interplay with Transcription and Epigenetic Regulation
19 DNA Replication and Histone M odification
20 Establishment and Maintenance of DNA Methylation
21 Active DNA Demethylation in Development, Human Disease, and Cancer
BM Index.

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