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Title
Systemic sclerosis [electronic resource] : basic and translational research / Kazuhiko Takehara, Manabu Fujimoto, Masataka Kuwana, editors.
ISBN
9784431557081 (electronic book)
4431557083 (electronic book)
9784431557074
Published
Tokyo : Springer, 2016.
Language
English
Description
1 online resource
Item Number
10.1007/978-4-431-55708-1 doi
Call Number
RC924.5.S34
Dewey Decimal Classification
616.77
Summary
This book provides a comprehensive review of the recent advances in the research of systemic sclerosis (scleroderma). Systemic sclerosis is a complex autoimmune disease characterized by vasculopathy, fibrosis, and immune activation. This disease is also associated with certain susceptibility genes and is affected by epigenetic regulation. Recent studies have revealed a variety of new evidence suggestive of the pathogenesis of the disease. These include endothelial progenitor cells, cytokines and growth factors, and B cells. Studies using animal models have also provided novel insight into the pathomechanisms. In addition to these topics, the book covers clinical research regarding biomarkers and autoantibodies. This volume will benefit all rheumatologists and dermatologists as well as basic scientists, especially immunologists, molecular biologists, and biochemists.
Bibliography, etc. Note
Includes bibliographical references.
Access Note
Access limited to authorized users.
Source of Description
Online resource; title from PDF title page (viewed February 9, 2016)
Available in Other Form
Print version: 9784431557074
1
Fibrosis: overview 2
Autoimmunity in systemic sclerosis: Overview 3
Endothelial progenitor cell 4
Animal models of systemic sclerosis 5
Genetics of Systemic Sclerosis 6
Role of the Interleukin-1 Family in the Fibrogenic Phenotype in Systemic Sclerosis 7
Interleukin-6 in the Pathogenesis of Systemic Sclerosis 8
Epigenetics 9
Transforming Growth Factor-€ and Connective Tissue Growth Factor 10
Endothelin 11
The Role of B cells in Systemic Sclerosis 12
Fli1 13
Biomarker 14
Autoantibodies in Systemic Sclerosis.
