The initiation of DNA replication in eukaryotes [electronic resource] / Daniel L. Kaplan, editor.
Kaplan, Daniel L., author, editor.
2016
QH581.2
Available Online

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Title The initiation of DNA replication in eukaryotes [electronic resource] / Daniel L. Kaplan, editor.
ISBN 9783319246963 (electronic book)
3319246968 (electronic book)
9783319246949
DOI https://doi.org/10.1007/978-3-319-24696-3
Published Cham : Springer, [2016]
Copyright ©2016
Language English
Description 1 online resource : color illustrations
Other Standard Identifiers 10.1007/978-3-319-24696-3 doi
Call Number QH581.2
Dewey Decimal Classification 571.6
Summary Every time a cell divides, a copy of its genomic DNA has to be faithfully copied to generate new genomic DNA for the daughter cells. The process of DNA replication needs to be precisely regulated to ensure that replication of the genome is complete and accurate, but that re-replication does not occur. Errors in DNA replication can lead to genome instability and cancer. The process of replication initiation is of paramount importance, because once the cell is committed to replicate DNA, it must finish this process. A great deal of progress has been made in understanding how DNA replication is initiated in eukaryotic cells in the past ten years, but this is the first one-source book on these findings. The Initiation of DNA Replication in Eukaryotes will focus on how DNA replication is initiated in eukaryotic cells. While the concept of replication initiation is simple, its elaborate regulation and integration with other cell processes results in a high level of complexity. This book will cover how the position of replication initiation is chosen, how replication initiation is integrated with the phases of the cell cycle, and how it is regulated in the case of damage to DNA. It is the cellular protein machinery that enables replication initiation to be activated and regulated. We now have an in-depth understanding of how cellular proteins work together to start DNA replication, and this new resource will reveal a mechanistic description of DNA replication initiation as well.
Bibliography, etc. Note Includes bibliographical references and index.
Access Note Access limited to authorized users.
Source of Description Online resource; title from PDF title page (viewed February 16, 2016).
Added Author Kaplan, Daniel L., author, editor.
Available in Other Form Print version: 9783319246949
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1. Introduction to DNA replication initiation in eukaryotes
2. Choice of origins and replication timing control in yeast
3. Replication timing and initiation in metazoans.- 4. Replication timing gradients and origin activation
5. Genome wide localization of replication initiation factors
6. Genome scale analysis of metaozoan replication origins
7. Role of dormant origins in replication initiation
8. Centromeres and DNA replication initiation
9. Rif1 regulation of replication timing
10. Role of ORC in replication initiation.- 11. Licensing of replication origins- loading Mcm2-7
12. Role of chromatin in replication initiation
13. Role of Mcm2-7 in replication initiation
14. Role of CDK in replication initiation
15. Role of DDK in replication initiation
16. Roles of Sld2, Sld3, and Dpb11 in replication initiation
17. Role of Mcm10 in replication initiation
18. Role of post-translational modifications in replication initiation
19. Assembly of the Cdc45-Mcm2-7-GINS complex, the replication helicase.- 20. Activity of the Cdc45-Mcm2-7-GINS complex, the replication helicase
21. Structure function studies of replication initiation factors
22. Pol-alpha activation and coupling with helicase unwinding
23. Replication initiation and DNA damage
24. Protein phosphatases and replication initiation
25. Spindle checkpoints and replication initiation.- 26. Protein degradation and replication initiation
27. Break-induced replication.- 27. Meier Gorlin syndrome
28. Replication Stress and Cancer.

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