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Introduction; Contents; Chapter 1: Hepatocyte Growth Factor and Satellite Cell Activation; 1.1 Introduction; 1.2 Satellite Cell Activation; 1.3 Myogenic Cell Motility; 1.4 Zebrafish Single-Fiber Studies of Satellite Cell Activation; 1.5 Re-defining the Impact of Age on Satellite Cell Activation and Muscle-Growth Capacity; 1.6 Integrating Growth, Satellite-Cell Behaviour and Cytoskeletal Development; 1.7 Conclusion; References; Chapter 2: Cytokine Mediated Control of Muscle Stem Cell Function; 2.1 Introduction; 2.1.1 Skeletal Muscle; 2.2 Satellite Cells; 2.3 The Role of Satellite Cells
2.3.1 Muscle Regeneration and Growth2.3.2 Exercise and Adaptation; 2.3.3 Muscle Pathology; 2.4 Myogenic Regulatory Factors; 2.5 Interleukins and Their Role in Muscle Growth and Regeneration; 2.6 Interleukins and Myogenesis; 2.6.1 Proliferation; 2.6.2 Differentiation; 2.6.3 Interleukins Derived Macrophages and Myogenesis; 2.7 Conclusion; References; Chapter 3: The Role of Leukemia Inhibitory Factor Receptor Signaling in Skeletal Muscle Growth, Injury and Disease; 3.1 Introduction; 3.2 Varied Sources of LIFR Cytokines Regulating Muscle and Peripheral Homeostasis
3.3 LIFR Is Involved in Muscle Development Predominantly Via Neurotrophic Effects3.4 Indirect and Direct Effects of LIFR Cytokines Regulate Adult Muscle Cell Homeostasis; 3.5 Metabolic Functions of LIFR Cytokines; 3.6 Potential for LIFR Cytokines in Treating Muscular Dystrophies; 3.7 Conclusions; References; Chapter 4: Function of Membrane-Associated Proteoglycans in the Regulation of Satellite Cell Growth; 4.1 Introduction; 4.2 Skeletal Muscle Growth and Development; 4.3 Extracellular Matrix; 4.4 Cell Membrane-Associated Proteoglycans; 4.4.1 Syndecans; 4.4.2 Glypican-1; 4.4.3 Betaglycan
4.4.4 CD444.4.5 Neuropilin; 4.5 Cytokines and Growth Factors Affecting Muscle Development and Growth; 4.5.1 Interleukin-6; 4.5.2 Leukemia Inhibitory Factor; 4.5.3 Tumor Necrosis Factor-α; 4.5.4 Hepatocyte Growth Factor; 4.5.5 Insulin-Like Growth Factors; 4.5.6 Transforming Growth Factor-Beta; 4.6 Conclusions; References; Chapter 5: The TGF-β Signalling Network in Muscle Development, Adaptation and Disease; 5.1 Introduction; 5.2 The TGF-β Signalling Network in Overview; 5.2.1 Ligand Synthesis and Secretion
5.2.2 Prodomains Control TGF-β Ligand Activity and Localisation in the Extracellular Matrix5.2.3 TGF-β Family Members Target Specific Receptor Complexes and Transcription Factors; 5.2.4 Extracellular Regulation of TGF-β Signalling; 5.3 The Role of TGF-β Signalling in Skeletal Muscle Development and Homeostasis; 5.3.1 Skeletal Muscle Development; 5.3.2 Myostatin as a Regulator of Myogenesis; 5.3.3 Myostatin as a Regulator of Muscle Fibre Size; 5.3.4 Other TGF-β Proteins as Regulators of Muscle Development and Maturation; 5.4 The Role of TGF-β Signalling in Post-natal Muscle Regeneration
2.3.1 Muscle Regeneration and Growth2.3.2 Exercise and Adaptation; 2.3.3 Muscle Pathology; 2.4 Myogenic Regulatory Factors; 2.5 Interleukins and Their Role in Muscle Growth and Regeneration; 2.6 Interleukins and Myogenesis; 2.6.1 Proliferation; 2.6.2 Differentiation; 2.6.3 Interleukins Derived Macrophages and Myogenesis; 2.7 Conclusion; References; Chapter 3: The Role of Leukemia Inhibitory Factor Receptor Signaling in Skeletal Muscle Growth, Injury and Disease; 3.1 Introduction; 3.2 Varied Sources of LIFR Cytokines Regulating Muscle and Peripheral Homeostasis
3.3 LIFR Is Involved in Muscle Development Predominantly Via Neurotrophic Effects3.4 Indirect and Direct Effects of LIFR Cytokines Regulate Adult Muscle Cell Homeostasis; 3.5 Metabolic Functions of LIFR Cytokines; 3.6 Potential for LIFR Cytokines in Treating Muscular Dystrophies; 3.7 Conclusions; References; Chapter 4: Function of Membrane-Associated Proteoglycans in the Regulation of Satellite Cell Growth; 4.1 Introduction; 4.2 Skeletal Muscle Growth and Development; 4.3 Extracellular Matrix; 4.4 Cell Membrane-Associated Proteoglycans; 4.4.1 Syndecans; 4.4.2 Glypican-1; 4.4.3 Betaglycan
4.4.4 CD444.4.5 Neuropilin; 4.5 Cytokines and Growth Factors Affecting Muscle Development and Growth; 4.5.1 Interleukin-6; 4.5.2 Leukemia Inhibitory Factor; 4.5.3 Tumor Necrosis Factor-α; 4.5.4 Hepatocyte Growth Factor; 4.5.5 Insulin-Like Growth Factors; 4.5.6 Transforming Growth Factor-Beta; 4.6 Conclusions; References; Chapter 5: The TGF-β Signalling Network in Muscle Development, Adaptation and Disease; 5.1 Introduction; 5.2 The TGF-β Signalling Network in Overview; 5.2.1 Ligand Synthesis and Secretion
5.2.2 Prodomains Control TGF-β Ligand Activity and Localisation in the Extracellular Matrix5.2.3 TGF-β Family Members Target Specific Receptor Complexes and Transcription Factors; 5.2.4 Extracellular Regulation of TGF-β Signalling; 5.3 The Role of TGF-β Signalling in Skeletal Muscle Development and Homeostasis; 5.3.1 Skeletal Muscle Development; 5.3.2 Myostatin as a Regulator of Myogenesis; 5.3.3 Myostatin as a Regulator of Muscle Fibre Size; 5.3.4 Other TGF-β Proteins as Regulators of Muscle Development and Maturation; 5.4 The Role of TGF-β Signalling in Post-natal Muscle Regeneration