Radiobiology of glioblastoma [electronic resource] : recent advances and related pathobiology / Luigi Pirtoli, Giovanni Luca Gravina and Antonio Giordano, editors.
Pirtoli, Luigi, editor.; Gravina, Giovanni Luca, editor.; Giordano, Antonio, editor.
2016
RC280.B7
Available Online

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Title Radiobiology of glioblastoma [electronic resource] : recent advances and related pathobiology / Luigi Pirtoli, Giovanni Luca Gravina and Antonio Giordano, editors.
ISBN 9783319283050 (electronic book)
3319283057 (electronic book)
9783319283036
Published Switzerland : Humana Press, 2016.
Language English
Description 1 online resource.
Call Number RC280.B7
Dewey Decimal Classification 616.99/480642
Summary This text properly considers the most recent and relevant advances in molecular RB of GB, taking into account the related topics of pathobiology, and underscores the most promising translational perspectives from the preclinical to the clinical domain. Section I (From Bedside to Bench) discusses conditions associated with RT resistance of GB and the consequent RB hints, technology improvements intended to overcome RT-resistance of GB, mathematical modeling of RB parameters from clinical studies, the present impact of molecular prognostic factors in therapy of GB, and RT tolerance of normal brain. Section II (Preclinical Research and Pathobiology Topics) presents the traditional and mechanistic/molecular approaches to RB of GB, genetic and epigenetic studies on GB, issues of cell-death pathways, stem-like cells, invasiveness, tumor microenvironment, hypoxia, mi-RNA manipulations, and nanoparticle technology. Section III (Translational Perspectives) presents RB issues related to molecular profiling and classification of GB as frames of reference for clinical studies, translational perspectives of gene therapy, evolving protocols based on pre-clinical data and large data-bases and ontologic models. Radiobiology of Glioblastoma: Recent Advances and Related Pathobiology will be of great value to pathologists, medical oncologists, radiation oncologists as well as basic researchers and clinical investigators. .
Bibliography, etc. Note Includes bibliographical references.
Access Note Access limited to authorized users.
Source of Description Online resource; title from PDF title page (viewed July 5, 2016).
Added Author Pirtoli, Luigi, editor.
Gravina, Giovanni Luca, editor.
Giordano, Antonio, editor.
Series Current clinical pathology.
Available in Other Form Radiobiology of Glioblastoma : Recent Advances and Related Pathobiology
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Introduction and Background
The "Radio-resistance" of Glioblastoma in the Clinical Setting, and the Present Therapeutic Options
Radiobiological Hints from Clinical Studies
Chemo-radiotherapy: Radiation Total Dose and Fractionation
Clinical Evidence and Radiobiological Background of Particle Radiation Therapy
Mathematical Modeling of Radiobiological Parameters from Clinical Studies
Clinical, Pathology and Molecular Prognostic Parameters of Response to Chemo- and Radiotherapy from Clinical Series
Radiation Tolerance of Normal Brain: QUANTEC 2010 and Beyond
Basic Knowledge of Glioblastoma Radiobiology
Molecular Radiobiology and Mathematical Modeling
Genetic and Epigenetic Determinants in Tumor Initiation and Progression
Tumor Microenvironment
Cell Death Pathways, with Special Regard to Ionizing Radiation and Temozolomide Therapy
mi-RNA Manipulation in Modifying Radiation Sensitivity in Glioblastoma Models
Glioma Stem-like Cells and Radiation Resistance
Hypoxia and Radiation Resistance
Invasiveness and Radiation Failures
Nanoparticle Technology for Research Radiobiology
The Molecular Classification of Glioblastoma as a Translational Instrument
Translational Perspectives for Gene Therapy
Pre-Clinical Models of Glioblastoma in Radiobiology: Evolving Protocols and Research Methods
From Molecular to Clinical Radiation Biology
Perspectives of the Large Data-Bases and Ontologic Models of Correlation of Pre-clinical and Clinical Results
Conclusive Remarks and Perspectives for Future Research.

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