Inflammation and metastasis [electronic resource] / Yoshiro Maru.
Maru, Yoshiro, author.
2016
RB131
Available Online

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Title Inflammation and metastasis [electronic resource] / Yoshiro Maru.
Author Maru, Yoshiro, author.
ISBN 9784431560241 (electronic book)
4431560246 (electronic book)
9784431560227
DOI https://doi.org/10.1007/978-4-431-56024-1
Published Japan : Springer, 2016.
Language English
Description 1 online resource (xx, 505 pages) : illustrations.
Other Standard Identifiers 10.1007/978-4-431-56024-1 doi
Call Number RB131
Dewey Decimal Classification 616/.0473
Summary This book provides the latest information on cancer metastasis from the standpoint of inflammation, especially innate immune reactions caused by endogenous mediators but not exogenous pathogens, with ideas on how to understand the complicated mechanisms of metastasis as well as to interpret therapeutic targets. The book includes the topic of the emerging roles of endogenous TLR4 ligands whose functions are shared intriguingly by metastasis and auto-inflammatory diseases such as rheumatoid arthritis. For example, most cancer therapies established so far are effective initially. However, they eventually face the great obstacles of drug resistance, immune evasion, and metastatic progression. One of the endogenous TLR4 ligands is thought to contribute to all three processes. The most important features of the book are to explain a concept of homeostatic inflammation, disturbance of which in the lungs gives rise to the establishment of a pre-metastatic pulmonary microenvironment based on primary tumor-mediated hijacking of the innate immune defense system against respiratory infection. In addition, structure-based thinking is another important feature of this book. It is proposed that inflammation forms a functional triangle with angiogenesis and coagulation, in the center of which cancer is located. Given the proposal of precision medicine by President Obama in the United States in 2015 and the recent success of immune-modulator-based therapy, this book will appeal to researchers in a variety of fields with the title of the book connecting the worst disease (metastasis) and the most fundamental event (inflammation) that is common to many diseases.
Bibliography, etc. Note Incldues bibliographical references and index.
Access Note Access limited to authorized users.
Source of Description Online resource; title from PDF title page (SpringerLink, viewed August 5, 2016).
Available in Other Form Print version: 9784431560227
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PART I WHAT IS INFLAMMATION
1 General thinking
2 Leukocytes
3 Triangle
4 Sterile inflammation
PART II WHAT IS ENDOGENOUS LIGAND
5 Self and non-self
6 Field extension
7 Endogenous TLR4 ligands
8 Auto-inflammatory disorders
PART III CANCER
9 Cancer in general
10 Basic research
11 Tumor microenvironment
12 Whole-body matter
PART IV HOMEOSTATIC INFLAMMATION AND METASTASIS
13 Pre-metastasis
14 What is homeostasis
15 Explanation of metastasis
16 Therapeutic potential.

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