Linked e-resources
Details
Table of Contents
Contributors; Chapter 1: Distal Esophageal Adenocarcinoma andßGastric Adenocarcinoma: Time forßaßShared Research Agenda; References; Part I: Introduction; Chapter 2: Clonal Evolution ofßStem Cells inßtheßGastrointestinal Tract; How Many Stem Cells Are inßtheßIntestinal Crypt?; What Factors Determine Stem Cell Number inßtheßCrypt?; Neutral Competition andßtheßRules ofßtheßGame; Dynamics inßtheßPyloric Glands ofßtheßStomach Epithelium; Clone Behavior inßCorpus Glands ofßStomach Epithelia; References; Chapter 3: The Complex, Clonal, andßControversial Nature ofßBarrett's Esophagus.
Introduction The Basic Unit ofßtheßHuman GI Tract Mucosa Is theßGland; Gland Phenotypes inßBarrett's esophagus; The Stem Cell Niche andßNiche succession inßBarrett's; Tracing Clonal Lineages inßBarrett's; Clonal Expansions inßNon-dysplastic Barrett's Esophagus; Clonal Dynamics andßExpansion inßBarrett's Esophagus; Combining Clonal Labeling withßPhenotype; Clonal Expansion Postradiofrequency Ablation (RFA); Conclusion; References; Chapter 4: A New Pathologic Assessment ofßGastroesophageal Reflux Disease: TheßSquamo-Oxyntic Gap; Introduction.
Progression ofßGORD withßEmpiric PPI Therapy Definition ofßIrreversibility inßGORD: vCLO; Cause ofßGORD: Lower Esophageal Sphincter Damage; The Normal LOS andßConsequence ofßAbdominal LOS Damage; Mechanism ofßLOS Damage; Relationship Between LOS Damage andßGORD; Mechanism ofßMaintenance ofßLOS Pressure; In Search ofßAccurate Definitions; Histologic Definitions ofßEpithelia inßtheßEsophagus andßStomach; The Squamo-Oxyntic Gap; Definition ofßtheßSquamo-Oxyntic Gap; The Length ofßtheßSquamo-Oxyntic Gap; The Epithelial Composition ofßtheßSquamo-Oxyntic Gap.
The Location ofßtheßSquamo-Oxyntic Gap Autopsy Studies ofßtheßGOJ; The Squamo-Oxyntic Gap inßDifferent Populations; People Without GORD Symptoms; GORD Patients withßNo Endoscopic Abnormality; Patients withßaßvCLO at Endoscopy; The Distal Part ofßtheßSquamo-Oxyntic Gap Correlates withßDamage toßtheßAbdominal Los; Definition ofßtheßGastroesophageal Junction (GOJ); Genesis andßProgression ofßtheßSquamo-Oxyntic Gap; Columnar Metaplasia DueßtoßLOS Effacement Without Reflux; Columnar Metaplasia ofßtheßEsophageal Body DueßtoßLOS Failure andßReflux; A New Pathologic Test ofßLos Damage.
Measurement at Autopsy Measurement inßEsophago-Gastrectomy Specimens; Measurement at Endoscopy withßPresent Biopsy Forceps; Future Ideal Endoscopic Measurement; Conclusion; References; Part II: Cancer Progression in the Distal Esophagus; Chapter 5: Diagnosis by Endoscopy andßAdvanced Imaging ofßBarrett's Neoplasia; Introduction; Endoscopic Diagnosis ofßEarly Neoplasia inßBarrett's Esophagus; Use Best Endoscope Available; You Do Not Detect What YoußSee, YoußDetect What YoußRecognize; Perform aßSystematic Endoscopic Inspection; Advanced Imaging Techniques inßBarrett's Esophagus.
Introduction The Basic Unit ofßtheßHuman GI Tract Mucosa Is theßGland; Gland Phenotypes inßBarrett's esophagus; The Stem Cell Niche andßNiche succession inßBarrett's; Tracing Clonal Lineages inßBarrett's; Clonal Expansions inßNon-dysplastic Barrett's Esophagus; Clonal Dynamics andßExpansion inßBarrett's Esophagus; Combining Clonal Labeling withßPhenotype; Clonal Expansion Postradiofrequency Ablation (RFA); Conclusion; References; Chapter 4: A New Pathologic Assessment ofßGastroesophageal Reflux Disease: TheßSquamo-Oxyntic Gap; Introduction.
Progression ofßGORD withßEmpiric PPI Therapy Definition ofßIrreversibility inßGORD: vCLO; Cause ofßGORD: Lower Esophageal Sphincter Damage; The Normal LOS andßConsequence ofßAbdominal LOS Damage; Mechanism ofßLOS Damage; Relationship Between LOS Damage andßGORD; Mechanism ofßMaintenance ofßLOS Pressure; In Search ofßAccurate Definitions; Histologic Definitions ofßEpithelia inßtheßEsophagus andßStomach; The Squamo-Oxyntic Gap; Definition ofßtheßSquamo-Oxyntic Gap; The Length ofßtheßSquamo-Oxyntic Gap; The Epithelial Composition ofßtheßSquamo-Oxyntic Gap.
The Location ofßtheßSquamo-Oxyntic Gap Autopsy Studies ofßtheßGOJ; The Squamo-Oxyntic Gap inßDifferent Populations; People Without GORD Symptoms; GORD Patients withßNo Endoscopic Abnormality; Patients withßaßvCLO at Endoscopy; The Distal Part ofßtheßSquamo-Oxyntic Gap Correlates withßDamage toßtheßAbdominal Los; Definition ofßtheßGastroesophageal Junction (GOJ); Genesis andßProgression ofßtheßSquamo-Oxyntic Gap; Columnar Metaplasia DueßtoßLOS Effacement Without Reflux; Columnar Metaplasia ofßtheßEsophageal Body DueßtoßLOS Failure andßReflux; A New Pathologic Test ofßLos Damage.
Measurement at Autopsy Measurement inßEsophago-Gastrectomy Specimens; Measurement at Endoscopy withßPresent Biopsy Forceps; Future Ideal Endoscopic Measurement; Conclusion; References; Part II: Cancer Progression in the Distal Esophagus; Chapter 5: Diagnosis by Endoscopy andßAdvanced Imaging ofßBarrett's Neoplasia; Introduction; Endoscopic Diagnosis ofßEarly Neoplasia inßBarrett's Esophagus; Use Best Endoscope Available; You Do Not Detect What YoußSee, YoußDetect What YoußRecognize; Perform aßSystematic Endoscopic Inspection; Advanced Imaging Techniques inßBarrett's Esophagus.