Linked e-resources
Details
Table of Contents
Preface; Contents; 5003 Translational Mouse Models of Autism: Advancing Toward Pharmacological Therapeutics; Abstract; 1 Introduction; 2 Animal Models to Understand the Causes of Autism; 3 Mouse Behavioral Assays Relevant to the Diagnostic and Associated Symptoms of Autism; 3.1 Social Tests; 3.2 Social Communication; 3.3 Motor Stereotypies, Repetitive Behaviors, and Restricted Interests; 3.4 Associated Symptoms; 4 Evaluating Pharmacological Therapeutics in Animal Models with High Construct Validity and Strong Face Validity for ASD; 5 Conclusions; Acknowledgments; References
5013 Translatable and Back-Translatable Measurement of Impulsivity and Compulsivity: Convergent and Divergent ProcessesAbstract; 1 Introduction; 2 Impulsivity; 2.1 Waiting Impulsivity; 2.1.1 Neural Networks and Neurochemistry; 2.2 Stop-Signal Reaction Time; 2.2.1 Neural Substrates; 2.3 Delay Discounting; 2.3.1 Neural Substrates; 2.4 Reflection Impulsivity; 2.4.1 Neural Substrates; 3 Compulsivity; 3.1 Cognitive Inflexibility; 3.1.1 Neural Substrates; 3.2 Stimulus-Response (Habit) Learning; 3.2.1 Neural Substrates; 3.3 Motor Stereotypy; 4 Synthesis and Future Perspectives
4.1 Neural Considerations: Fronto-striatal Nodes and Opponency Processes4.2 Neurochemical Considerations: Dopamine and Serotonin; 5 Conclusion; Acknowledgements; References; 5014 Translational Models of Gambling-Related Decision Making; Abstract; 1 Introduction; 1.1 The Iowa Gambling Task; 2 Challenges to Translational Research into Gambling; 2.1 Multiple Types of Gambling; 2.2 Reliance upon Models of Drug Addiction; 2.3 The Puzzle of Dopamine and GD; 2.4 Comorbidity of GD with Other Psychiatric Conditions; 2.5 Subjective Biases in Decision-Making Under Uncertainty; 3 Escalation of Commitment
3.1 Loss-Chasing4 The Near-miss Effect; 5 Conclusion; References; 5005 Translational Research on Nicotine Dependence; Abstract; 1 Introduction and Overarching Model; 2 Role of the Endogenous Opioid System in Nicotine Reward and Relapse; 2.1 Biological Mechanisms; 2.2 Future Directions for Treatment; 3 Interactions Between Smoking and Overeating; 3.1 Post-cessation Weight Gain; 3.2 Altered Nicotine Reward in Obesity; 3.3 Future Directions for Treatment; 4 Nicotine Withdrawal: Cognition and Affect; 4.1 Withdrawal-Related Cognitive Changes; 4.2 Withdrawal-Related Affective Changes
4.3 Future Directions for Treatment5 Summary and Conclusion; References; 5006 The Need for Treatment Responsive Translational Biomarkers in Alcoholism Research; Abstract; 1 Alcohol Addiction: An Area of Major Unmet Medical Needs; 2 The Aspirations of Translational Research for Alcohol Addiction; 3 The Promise of Translational Biomarkers; 3.1 Alcohol-Induced Dopamine (DA) Activation as Translational Biomarker; 3.2 Measures of Glutamate Activity as Translational Biomarkers; 4 Future Directions: The Whole-More than the Sum of Its Parts?; 5 Conclusion; References
5013 Translatable and Back-Translatable Measurement of Impulsivity and Compulsivity: Convergent and Divergent ProcessesAbstract; 1 Introduction; 2 Impulsivity; 2.1 Waiting Impulsivity; 2.1.1 Neural Networks and Neurochemistry; 2.2 Stop-Signal Reaction Time; 2.2.1 Neural Substrates; 2.3 Delay Discounting; 2.3.1 Neural Substrates; 2.4 Reflection Impulsivity; 2.4.1 Neural Substrates; 3 Compulsivity; 3.1 Cognitive Inflexibility; 3.1.1 Neural Substrates; 3.2 Stimulus-Response (Habit) Learning; 3.2.1 Neural Substrates; 3.3 Motor Stereotypy; 4 Synthesis and Future Perspectives
4.1 Neural Considerations: Fronto-striatal Nodes and Opponency Processes4.2 Neurochemical Considerations: Dopamine and Serotonin; 5 Conclusion; Acknowledgements; References; 5014 Translational Models of Gambling-Related Decision Making; Abstract; 1 Introduction; 1.1 The Iowa Gambling Task; 2 Challenges to Translational Research into Gambling; 2.1 Multiple Types of Gambling; 2.2 Reliance upon Models of Drug Addiction; 2.3 The Puzzle of Dopamine and GD; 2.4 Comorbidity of GD with Other Psychiatric Conditions; 2.5 Subjective Biases in Decision-Making Under Uncertainty; 3 Escalation of Commitment
3.1 Loss-Chasing4 The Near-miss Effect; 5 Conclusion; References; 5005 Translational Research on Nicotine Dependence; Abstract; 1 Introduction and Overarching Model; 2 Role of the Endogenous Opioid System in Nicotine Reward and Relapse; 2.1 Biological Mechanisms; 2.2 Future Directions for Treatment; 3 Interactions Between Smoking and Overeating; 3.1 Post-cessation Weight Gain; 3.2 Altered Nicotine Reward in Obesity; 3.3 Future Directions for Treatment; 4 Nicotine Withdrawal: Cognition and Affect; 4.1 Withdrawal-Related Cognitive Changes; 4.2 Withdrawal-Related Affective Changes
4.3 Future Directions for Treatment5 Summary and Conclusion; References; 5006 The Need for Treatment Responsive Translational Biomarkers in Alcoholism Research; Abstract; 1 Alcohol Addiction: An Area of Major Unmet Medical Needs; 2 The Aspirations of Translational Research for Alcohol Addiction; 3 The Promise of Translational Biomarkers; 3.1 Alcohol-Induced Dopamine (DA) Activation as Translational Biomarker; 3.2 Measures of Glutamate Activity as Translational Biomarkers; 4 Future Directions: The Whole-More than the Sum of Its Parts?; 5 Conclusion; References