Sphingosine-1-phosphate signaling in immunology and infectious diseases / Michael B.A. Oldstone, Hugh Rosen, editors.
Oldstone, Michael B. A., editor.; Rosen, Hugh (Professor of chemical physiology), editor.
2014
QR1 .E6 v.378
Available Online

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Title Sphingosine-1-phosphate signaling in immunology and infectious diseases / Michael B.A. Oldstone, Hugh Rosen, editors.
ISBN 9783319058795 (electronic book)
3319058797 (electronic book)
3319058789
9783319058788
DOI https://doi.org/10.1007/978-3-319-05879-5
Published Cham ; New York : Springer, [2014]
Copyright ©2014
Language English
Description 1 online resource (vii, 184 pages) : illustrations.
Other Standard Identifiers 10.1007/978-3-319-05879-5 doi
Call Number QR1 .E6 v.378
Dewey Decimal Classification 615.3/7
Summary This volume focuses on the role of sphingosine-1-phosphate (S1P) and its analogs in the induced sequestration of lymphocytes in secondary lymphoid organs or in the microenvironment of tissues involved in infection or autoimmune disease. Initial chapters define the pathways to understand S1P signaling. They cover the organization of signaling systems, the structural biology of the S1P1 receptor, and the chemical and genetic tools that are available and useful to explore this area of research and therapeutics. The later chapters highlight S1P and endothelial integrity, lymphocyte migration in the spleen, and S1P agonist in controlling immunopathologic manifestations of acute respiratory influenza virus infection (in the lung), and its accompanying cytokine storm as well as immunopathologic disease of the central nervous system, including the beginning of treatments in multiple sclerosis. One chapter reveals the possible involvement of other lipid molecules, their use for better understanding lipid signaling, and their potential in the modulation of immune responses.
Bibliography, etc. Note Includes bibliographical references and index.
Access Note Access limited to authorized users.
Source of Description Description based on PDF title page (viewed April 22, 2014).
Added Author Oldstone, Michael B. A., editor.
Rosen, Hugh (Professor of chemical physiology), editor.
Series Current topics in microbiology and immunology ; 378.
Available in Other Form Sphingosine-1-phosphate signaling in immunology and infectious diseases.
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All Resources
The organization of the sphingosine-1-phosphate signaling system / Hugh Rosen, M. Germana Sanna, Pedro J. Gonzalez-Cabrera and Edward Roberts
Structural biology of the S1P₁ receptor / Michael A. Hanson and Robert Peach
Chemical and genetic tools to explore S1P biology / Stuart M. Cahalan
S1P control of endothelial integrity / Yuquan Xiong and Timothy Hla
Blood, sphingosine-1-phosphate and lymphocyte migration dynamics in the spleen / Tal I. Arnon and Jason G. Cyster
Cytokine storm plays a direct role in the morbidity and mortality from influenza virus infection and is chemically treatable with a single sphingosine-1-phosphate agonist molecule / Michael B.A. Oldstone and Hugh Rosen
Sphingosine-1-phosphate and central nervous system / Roland Martin and Mireia Sospedra
RORs in autoimmune disease / Mi Ra Chang, Hugh Rosen and Patrick R. Griffin.

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