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1 Overview of Bacteriophage Lifecycles and Applications; 1 Introduction; 2 Phage Infection and Life-Cycle; 2.1 Lytic Phage; 2.2 Temperate Phage; 3 Phage Infection Stages; 3.1 Phage Entry; 3.2 DNA Replication; 3.3 Phage Assembly; 3.3.1 Tailed (dsDNA) Phages; 3.3.2 ssDNA Phages; 3.3.3 ssRNA Phages; 4 Hurdles for Phage-Based Therapeutics; References; 2 Phage for Biocontrol; Abstract; 1 Introduction; 2 The Importance of Using Recombinant Phage; 3 Recombinant Phage for the Treatment of Bacterial Infections; 3.1 Escherichia coli (E. coli); 3.2 Staphylococcus aureus (S. aureus)
3.3 Chlamydia trachomatis3.4 Pseudomonas aeruginosa (PA); 3.5 Helicobacter pylori (H. pylori); 4 Phage as Drug Delivery Vehicles for the Treatment of Bacterial Infections; 5 Summary; References; 3 Phage Device Coatings; Abstract; 1 Introduction; 2 Biofilms on Medical Devices; 2.1 Contributors to Biofilm Resistance; 3 Alternative Medical Coating Devices; 4 Bacteriophage as Bioactive Coatings; 5 Conclusions; References; 4 Bacteriophages Functionalized for Gene Delivery and the Targeting of Gene Networks; Abstract; 1 Introduction to Phage Mediated Delivery of Genetic Material
2 Bacteriophages as Gene Delivery Vehicles3 Phages as Cytotoxic Agents in Eukaryotes; 4 Phages for Delivery to the Central Nervous System; 5 Conclusions; References; 5 Phage Probiotics; Abstract; 1 Introduction: The Gut Microbiota and Probiotics; 2 Roles of the Gut Microbiota and Probiotics; 2.1 Protection Against Pathogens; 2.2 Metabolism; 2.3 Immunomodulation; 2.4 Tissue Development and Maintenance; 3 Bacteriophages in the Gut; 3.1 Phage Population Dynamics; 3.2 Protection Against Pathogens and Immunomodulation; 4 Applications of Phage; 4.1 Lytic Phage Therapy; 4.2 Phage Biotechnology
5 ConclusionsReferences; 6 Phage for Biodetection; Abstract; 1 Introduction to Phage-Based Biodetection; 2 Plaque Assays; 2.1 Phage Display for the Improvement of Plaque Assays; 3 Bacteriophage Indicator Organisms (Reporter Phage); 3.1 Fluorescence-Based Assays; 4 Immobilized Phage Particles as Probes for Bacterial Detection; 5 Conclusions; References; 7 Phage-Mediated Immunomodulation; 1 Introduction; 2 Immune Responses to Phage; 2.1 Anti-phage Innate Responses; 2.2 Humoral Immune Reposes to Phage (Anti-phage Antibodies)
2.3 Anti-phage Cellular Immunity and the Implications of the Impact of Phage on the Adaptive Responses (T and B Cells)3 Bacteriophage-Based Immune-Pharmaco-Therapies; 3.1 Phage Immunogenicity and Cancer Therapy; 3.1.1 Phage in Tumor Targeting; 3.1.2 Anti-tumor Phage Therapies; 3.2 Bacteriophage Immunotherapy Autoimmune Disorders; 3.3 Bacteriophage Immunotherapy for Drug Addiction; 3.4 Phages and Oxidative Stress; 4 Conclusions; References
3.3 Chlamydia trachomatis3.4 Pseudomonas aeruginosa (PA); 3.5 Helicobacter pylori (H. pylori); 4 Phage as Drug Delivery Vehicles for the Treatment of Bacterial Infections; 5 Summary; References; 3 Phage Device Coatings; Abstract; 1 Introduction; 2 Biofilms on Medical Devices; 2.1 Contributors to Biofilm Resistance; 3 Alternative Medical Coating Devices; 4 Bacteriophage as Bioactive Coatings; 5 Conclusions; References; 4 Bacteriophages Functionalized for Gene Delivery and the Targeting of Gene Networks; Abstract; 1 Introduction to Phage Mediated Delivery of Genetic Material
2 Bacteriophages as Gene Delivery Vehicles3 Phages as Cytotoxic Agents in Eukaryotes; 4 Phages for Delivery to the Central Nervous System; 5 Conclusions; References; 5 Phage Probiotics; Abstract; 1 Introduction: The Gut Microbiota and Probiotics; 2 Roles of the Gut Microbiota and Probiotics; 2.1 Protection Against Pathogens; 2.2 Metabolism; 2.3 Immunomodulation; 2.4 Tissue Development and Maintenance; 3 Bacteriophages in the Gut; 3.1 Phage Population Dynamics; 3.2 Protection Against Pathogens and Immunomodulation; 4 Applications of Phage; 4.1 Lytic Phage Therapy; 4.2 Phage Biotechnology
5 ConclusionsReferences; 6 Phage for Biodetection; Abstract; 1 Introduction to Phage-Based Biodetection; 2 Plaque Assays; 2.1 Phage Display for the Improvement of Plaque Assays; 3 Bacteriophage Indicator Organisms (Reporter Phage); 3.1 Fluorescence-Based Assays; 4 Immobilized Phage Particles as Probes for Bacterial Detection; 5 Conclusions; References; 7 Phage-Mediated Immunomodulation; 1 Introduction; 2 Immune Responses to Phage; 2.1 Anti-phage Innate Responses; 2.2 Humoral Immune Reposes to Phage (Anti-phage Antibodies)
2.3 Anti-phage Cellular Immunity and the Implications of the Impact of Phage on the Adaptive Responses (T and B Cells)3 Bacteriophage-Based Immune-Pharmaco-Therapies; 3.1 Phage Immunogenicity and Cancer Therapy; 3.1.1 Phage in Tumor Targeting; 3.1.2 Anti-tumor Phage Therapies; 3.2 Bacteriophage Immunotherapy Autoimmune Disorders; 3.3 Bacteriophage Immunotherapy for Drug Addiction; 3.4 Phages and Oxidative Stress; 4 Conclusions; References