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Preface; Contents; 1 Introduction ; 1.1 Toward New Tools; 1.2 Epigenetic Epidemiology; 1.3 Ecosystem Resilience; 1.3.1 Comorbid Disorders; 1.3.2 Some Cognitive Modules of Human Biology; 1.3.3 Cognition as ``Language'': an Introduction; 1.3.4 A Multiplicity of Resilience Topologies; 1.3.5 In Summary; 1.4 A First Survey of the Obesity Pandemic in the USA; 2 Models of Development; 2.1 The Spinglass Model; 2.2 Shifting Perspective: Cognition as an Information Source; 3 Groupoid Symmetries; 3.1 The First Level; 3.2 The Second Level; 3.3 Spontaneous Symmetry Breaking; 3.4 A Biological Example.

4 Epigenetic Catalysis4.1 The Basic Idea; 4.2 Rate Distortion Dynamics; 4.3 More Topology; 4.4 Inherited Epigenetic Memory; 4.5 Multiple Processes; 4.6 ``Coevolutionary'' Development; 4.7 Multiple Models; 4.8 Epigenetic Focus; 5 Developmental Disorders; 5.1 Network Information Theory; 5.2 Embedding Ecosystems as Information Sources; 5.3 Ecosystems Farm Development; 5.4 A Simple Probability Argument; 5.5 Developmental Shadows; 5.6 Epigenetic Programming of Artificial Systemsfor Biotechnology; 6 An Interim Perspective; 7 The Obesity Pandemic in the USA; 7.1 Introduction.

7.2 Stress and the HPA Axis7.3 HPA Axis Cognition; 7.4 Interacting Information Sources; 7.5 A HPA Axis Model; 7.6 Psychosocial Stress, Occupational Control, and Weight Gain; 7.7 Obesity as a Developmental Disorder; 7.8 Recent Trajectories of Structured Stress in the USA; 7.9 Confronting the Obesity Epidemic; 8 Heart Disease; 8.1 Coronary Heart Disease in the USA; 8.1.1 Cognition, Immune Cognition, and Culture; 8.1.2 Punctuated Interpenetration: Adapting to Pathogenic Hierarchy; 8.1.3 Implications for Intervention; 8.2 Thrombogenesis; 8.2.1 Control Theory: The Data Rate Theorem.

8.2.2 The Information Cost of Hemostatic Regulation8.2.3 Control Failure Dynamics; 8.2.4 Cognitive Symmetry Breaking; 8.2.5 Onset of ``Turbulent'' Clot Growth; 8.2.6 Implications for Intervention; 9 Cancer; 9.1 A Developmental Model; 9.2 Environmental Insult and Regulatory Failure; 10 Autoimmune Disorders; 10.1 Introduction; 10.2 Nonorthogonal Eigenmodes of Immune Cognition; 10.3 Circadian and Other Cycles; 10.4 The Retina of the Immune Response; 10.5 Circadian-Hormonal Cycle Synergism; 10.6 The Cognitive HPA Axis; 10.7 Phase Transitions of Interacting Information Systems.

10.8 Autoimmune Disease10.9 An Application to Asthma; 10.10 Images of Pathogenic Social Hierarchy; 11 Demoralization and Obesity in Upper Manhattan; 11.1 Introduction; 11.2 Methods; 11.2.1 Recruitment of the Mothers; 11.2.2 Prenatal Questionnaire; 11.2.3 Socioeconomic Data; 11.2.4 Chronic Community Stress Index; 11.3 Data Analysis; 11.4 Modeling Demoralization and Chronic Stress; 11.5 Results; 11.5.1 Demoralization and Chronic Stress; 11.5.2 Signal Transduction Modeling; 11.5.3 Body Mass Index; 11.5.4 Household Deprivation; 11.6 Discussion; 11.6.1 The Asymmetric Inverted ``U'' Curve.

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