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Preface; Acknowledgment; Contents; 1 Principles and Mechanism of MALDI-ToF-MS Analysis; Abstract; 1.1 Background of MALDI-ToF-MS; 1.2 Applications of MALDI-ToF-MS; 1.2.1 Biochemistry; 1.2.2 Organic Chemistry; 1.2.3 Polymer Chemistry; 1.2.4 Microbiology; 1.2.5 Medicine; 1.2.6 Nanotechnology; 1.3 Ionization Mechanism; 1.4 Time of Flight Mass Spectrometry Mechanism; 1.5 Detection Modes; 1.5.1 Linear Mode; 1.5.2 Reflection Mode; 1.6 Laser Range in MALDI; 1.7 Matrix Selection; 1.7.1 Limitations of Matrices; 1.8 Ionizing Agent Selection; 1.9 Fundamentals of Sample Preparation for MALDI Analysis
1.9.1 Analyzable and Non-analyzable Polymers1.9.2 Sample Preparation Techniques; 1.9.2.1 Dried-Droplet; 1.9.2.2 Fast Crystallization; 1.9.2.3 Spin Coating; 1.9.2.4 Layer by Layer; 1.9.2.5 Electrospray Deposition; 1.10 Mass Discrimination; 1.10.1 Alternative Solutions for Overcoming Mass Discrimination; 1.11 MALDI Coupling; 1.11.1 Ion-Mobility Time of Flight Mass Spectrometry (IMS-ToF-MS); 1.11.2 Fourier Transform Ion Cyclotron Resonance Mass Spectrometry (FT-ICR-MS); 1.11.3 Thin Layer Chromatography (TLC); 1.11.4 Size Exclusion Chromatograph (SEC); References
2 Fundamentals of Biosensors and Application of MALDI-ToF-MS in Bio-diagnostic DomainAbstract; 2.1 Biosensors; 2.2 Synthesis of Poly Methyl Methacrylate-Co-Methacrylic Acid P(MMA-Co-MAA) and Preparation of the Biochips; 2.3 Sample Preparation for MALDI Analysis; 2.4 MALDI Data Interpretation; 2.4.1 Different Species as the Possible Products of Soft Ionization; 2.4.2 General Structure of P(MMA-Co-MAA); 2.4.3 MALDI Analysis of PMMA; 2.4.4 MALDI Analysis of P(MMA-Co-MAA); 2.4.5 End-Group Analysis; 2.5 Role of MALDI Analysis in Bio-sensing Application of P(MMA-Co-MAA); 2.5.1 Reaction's Parameters
2.5.2 Chemistry Aspect2.5.3 Physical Aspect; References; 3 Fundamentals of Tissue Engineering and Application of MALDI-ToF-MS in Analysis of the Scaffold Materials; Abstract; 3.1 Tissue Engineering; 3.2 Synthesis of Poly Octanediol Citrate Acid-Sebacate Acid P(OCS) and Preparation of the Scaffold; 3.3 MALDI Analysis of P(OCS) and Sample Preparation; 3.4 MALDI Data Interpretation; 3.5 Role of MALDI Analysis in Tissue Engineering Application of P(OCS); 3.5.1 Reaction's Parameters; 3.5.2 Chemistry Aspect; 3.5.3 Mechanical Aspect; References
4 Fundamentals of Drug Delivery Systems and Application of MALDI-ToF-MS in Drug DeliveryAbstract; 4.1 Drug Delivery; 4.2 Synthesis of PCLT-CA and Preparation of Elastomeric Films and Coatings; 4.3 Sample Preparation for MALDI Analysis; 4.4 MALDI Data Interpretation; 4.5 The Role of MALDI Analysis in Drug Delivery Application of PCLT-CA; 4.5.1 Chemistry Aspect; 4.5.2 Mechanical Aspect; References; Summary
1.9.1 Analyzable and Non-analyzable Polymers1.9.2 Sample Preparation Techniques; 1.9.2.1 Dried-Droplet; 1.9.2.2 Fast Crystallization; 1.9.2.3 Spin Coating; 1.9.2.4 Layer by Layer; 1.9.2.5 Electrospray Deposition; 1.10 Mass Discrimination; 1.10.1 Alternative Solutions for Overcoming Mass Discrimination; 1.11 MALDI Coupling; 1.11.1 Ion-Mobility Time of Flight Mass Spectrometry (IMS-ToF-MS); 1.11.2 Fourier Transform Ion Cyclotron Resonance Mass Spectrometry (FT-ICR-MS); 1.11.3 Thin Layer Chromatography (TLC); 1.11.4 Size Exclusion Chromatograph (SEC); References
2 Fundamentals of Biosensors and Application of MALDI-ToF-MS in Bio-diagnostic DomainAbstract; 2.1 Biosensors; 2.2 Synthesis of Poly Methyl Methacrylate-Co-Methacrylic Acid P(MMA-Co-MAA) and Preparation of the Biochips; 2.3 Sample Preparation for MALDI Analysis; 2.4 MALDI Data Interpretation; 2.4.1 Different Species as the Possible Products of Soft Ionization; 2.4.2 General Structure of P(MMA-Co-MAA); 2.4.3 MALDI Analysis of PMMA; 2.4.4 MALDI Analysis of P(MMA-Co-MAA); 2.4.5 End-Group Analysis; 2.5 Role of MALDI Analysis in Bio-sensing Application of P(MMA-Co-MAA); 2.5.1 Reaction's Parameters
2.5.2 Chemistry Aspect2.5.3 Physical Aspect; References; 3 Fundamentals of Tissue Engineering and Application of MALDI-ToF-MS in Analysis of the Scaffold Materials; Abstract; 3.1 Tissue Engineering; 3.2 Synthesis of Poly Octanediol Citrate Acid-Sebacate Acid P(OCS) and Preparation of the Scaffold; 3.3 MALDI Analysis of P(OCS) and Sample Preparation; 3.4 MALDI Data Interpretation; 3.5 Role of MALDI Analysis in Tissue Engineering Application of P(OCS); 3.5.1 Reaction's Parameters; 3.5.2 Chemistry Aspect; 3.5.3 Mechanical Aspect; References
4 Fundamentals of Drug Delivery Systems and Application of MALDI-ToF-MS in Drug DeliveryAbstract; 4.1 Drug Delivery; 4.2 Synthesis of PCLT-CA and Preparation of Elastomeric Films and Coatings; 4.3 Sample Preparation for MALDI Analysis; 4.4 MALDI Data Interpretation; 4.5 The Role of MALDI Analysis in Drug Delivery Application of PCLT-CA; 4.5.1 Chemistry Aspect; 4.5.2 Mechanical Aspect; References; Summary