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Table of Contents
Preface; Contents; Contributors; Chapter 1: Adipocytes, Adipocytokines, andßCancer; Adipose Tissue; Adipocytokines andßCancer; Leptin; Adiponectin; Visfatin; Resistin; Apelin; Chemerin; Omentin; Nesfatin; Vaspin; Retinol-Binding Protein-4; Cytokines; Adipocytes and Tumor Metabolism; Conclusion; References; Chapter 2: Adiponectin, Obesity, andßCancer; Introduction; Adiponectin; Adiponectin Isoforms: Structural Considerations; Adiponectin Receptors; Adiponectin Modifications: Implication forßCancer; Adiponectin Signaling Pathways Related toßCancer.
Role ofßAdiponectin in Tumor Initiation andßProgression Types ofßCancer Associated withßObesity andßDecreased Adiponectin; Colorectal Cancer; Endometrial Cancer; Prostate Cancer; Breast Cancer; Gastric Cancer; Hematological Malignancies; The L/A Ratio; Adiponectin Chemopreventatives; Concluding Remarks; References; Chapter 3: Leptin inßCancer: Epidemiology and Mechanisms; An Overview ofßtheßEarly Studies ofßLeptin and Breast Cancer; Epidemiological Studies ofßLeptin andßBreast Cancer; Recent In Vitro Studies.
Preclinical Rodent Studies Evaluating Leptin's Effects onßMammary Tumor Development/Progression Leptin/Adiponectin Ratio; Leptin Antagonists; Leptin Advances Malignancy inßTumor Cells viaßAdditional Intrinsic Mechanisms; Leptin Effects onßtheßTumor Microenvironment also Contributes toßTumor Progression; Leptin's Role inßInflammation, Chemotaxis, andßAdaptive Immunity Impacts theßCancer Host's Immune Responses; Leptin and Non-breast Malignancies; Conclusions; References; Chapter 4: Leptin-Signaling Pathways asßTherapeutic Targets inßCancer.
Connection Between Dysregulated Leptin Levels andßCancer Effect ofßLeptin onßCancer Progression andßMetastasis; Leptin asßaßRegulator or anßImportant Participant ofßVarious Oncogenic Pathways; Canonical Signaling Pathways ofßLeptin; Noncanonical Signaling-Functional Interactions ofßLeptin withßMultiple Pathways; Leptin, Estrogen, andßAromatase; Leptin, IGF1, Insulin, andßEGFR; Leptin, Notch, andßWnt/Catenin Pathway; Strategies toßInhibit Leptin Signaling; Direct Inhibition ofßLeptin Signaling Using Small Molecule Inhibitors.
Activation ofßAdiponectin asßanßIndirect Strategy toßInhibit Leptin Conclusion; References; Chapter 5: Retinol Binding Protein 4: Role inßDiabetes andßCancer; Vitamin A: Absorption andßMetabolism; Retinoid-Binding Proteins; RBP4 andßTransport ofßRetinol inßtheßCirculation; Cellular Retinol-Binding Proteins; Vitamin A Uptake by Extrahepatic Tissues: RBP4 andßSTRA6; RBP4 Level Is Correlated withßObesity andßInsulin Resistance; RBP4 andßSTRA6 inßInsulin Resistance: AßMechanism ofßAction; Alternative Models forßUnderstanding How RBP4 Induces Insulin Resistance.
Role ofßAdiponectin in Tumor Initiation andßProgression Types ofßCancer Associated withßObesity andßDecreased Adiponectin; Colorectal Cancer; Endometrial Cancer; Prostate Cancer; Breast Cancer; Gastric Cancer; Hematological Malignancies; The L/A Ratio; Adiponectin Chemopreventatives; Concluding Remarks; References; Chapter 3: Leptin inßCancer: Epidemiology and Mechanisms; An Overview ofßtheßEarly Studies ofßLeptin and Breast Cancer; Epidemiological Studies ofßLeptin andßBreast Cancer; Recent In Vitro Studies.
Preclinical Rodent Studies Evaluating Leptin's Effects onßMammary Tumor Development/Progression Leptin/Adiponectin Ratio; Leptin Antagonists; Leptin Advances Malignancy inßTumor Cells viaßAdditional Intrinsic Mechanisms; Leptin Effects onßtheßTumor Microenvironment also Contributes toßTumor Progression; Leptin's Role inßInflammation, Chemotaxis, andßAdaptive Immunity Impacts theßCancer Host's Immune Responses; Leptin and Non-breast Malignancies; Conclusions; References; Chapter 4: Leptin-Signaling Pathways asßTherapeutic Targets inßCancer.
Connection Between Dysregulated Leptin Levels andßCancer Effect ofßLeptin onßCancer Progression andßMetastasis; Leptin asßaßRegulator or anßImportant Participant ofßVarious Oncogenic Pathways; Canonical Signaling Pathways ofßLeptin; Noncanonical Signaling-Functional Interactions ofßLeptin withßMultiple Pathways; Leptin, Estrogen, andßAromatase; Leptin, IGF1, Insulin, andßEGFR; Leptin, Notch, andßWnt/Catenin Pathway; Strategies toßInhibit Leptin Signaling; Direct Inhibition ofßLeptin Signaling Using Small Molecule Inhibitors.
Activation ofßAdiponectin asßanßIndirect Strategy toßInhibit Leptin Conclusion; References; Chapter 5: Retinol Binding Protein 4: Role inßDiabetes andßCancer; Vitamin A: Absorption andßMetabolism; Retinoid-Binding Proteins; RBP4 andßTransport ofßRetinol inßtheßCirculation; Cellular Retinol-Binding Proteins; Vitamin A Uptake by Extrahepatic Tissues: RBP4 andßSTRA6; RBP4 Level Is Correlated withßObesity andßInsulin Resistance; RBP4 andßSTRA6 inßInsulin Resistance: AßMechanism ofßAction; Alternative Models forßUnderstanding How RBP4 Induces Insulin Resistance.