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Title
Gastrointestinal stromal tumors : bench to bedside / Charles R. Scoggins, Chandrajit P. Raut, John T. Mullen, editors.
ISBN
9783319426327 (electronic book)
331942632X (electronic book)
9783319426303
Published
Cham, Switzerland : Springer, 2017.
Copyright
©2017
Language
English
Description
1 online resource (242 pages) : illustrations.
Other Standard Identifiers
10.1007/978-3-319-42632-7 doi
Call Number
RC280.D5
Dewey Decimal Classification
616.99433
Summary
This textbook provides a comprehensive, state of the art review of this field, and will serve as a valuable resource for clinicians, surgeons and researchers with an interest in GIST. The book reviews new data about risk factors for the disease, profiles the new staging system for GIST, highlights our current understanding of genetic mutations that lead to GIST, and provides new perspectives about imaging of GIST tumors. For localized disease, a greater appreciation of organ-sparing approaches and the importance of preservation of gastrointestinal function is discussed in detail, and advances in surgical techniques are highlighted, including minimally invasive surgery. For metastatic disease, the molecular biology of GIST is reviewed in a detailed and understandable manner, including the data that has fostered novel targeted approaches that have revolutionized management. Several landmark trials have been published in the last few years and are placed in context with respect to current management. Integration of surgery and systemic therapy through consolidative approaches has yielded provocative data that promises to further advance the field, and major advances in this domain are also discussed. Gastrointestinal Stromal Tumors: Bench to Bedside will serve as a very useful resource for physicians and researchers dealing with, and interested in, this challenging malignancy. It provides a concise yet comprehensive summary of the current status of the field that will help guide patient management and stimulate investigative efforts. All chapters are written by experts in their fields and include the most up to date scientific and clinical information.
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Access limited to authorized users.
Digital File Characteristics
text file PDF
Available in Other Form
Print version: 9783319426303
Etiology/Epidemiology
Pathology
Molecular Genetics of GIST
Pediatric GIST/Inheritable Disease
Natural History
Radiographic Imaging
Endoscopic Evaluation
Prognostic Factors for Localized Disease
Management of Localized GIST: Non-Surgical Approaches-Surveillance and Endoscopic Resection
Surgery for Localized GIST
Minimally Invasive Surgery for GIST
Neoadjuvant Rx and Surgical Consolidation
Imatinib
Management of Locally Advanced GIST
Prognostic Factors for Advanced GIST
Concepts of Targeted Therapy Management, Dose Escalation, Tailoring Therapy Based on Specific Mutations, Second Line Therapy
Surgical Debulking of Metastatic GIST
Liver Resection/Ablation of Metastatic GIST
Palliative Care.
