Linked e-resources
Details
Table of Contents
Preface; Contents; Biography; Chapter 1: Stem Cell Therapy inßNeurological andßNeurodegenerative Disease; 1.1 Introduction; 1.2 Types ofßStem Cells; 1.2.1 Embryonic Stem Cells; 1.2.2 Induced Pluripotent Stem Cells; 1.2.3 Tissue-Specific Stem Cells; 1.3 Stem Cell Therapy forßNeurological Diseases; 1.3.1 Alzheimer's Disease; 1.3.2 Parkinson's Disease; 1.3.3 Huntington's Disease; 1.3.4 Cancer; 1.4 Conclusion; References; Chapter 2: Stem Cell Therapy inßTraumatic Brain Injury; 2.1 Introduction; 2.2 Neuropathology ofßTraumatic Brain Injury; 2.2.1 Primary Injury After Traumatic Brain Injury.
2.2.2 Secondary Injury After Traumatic Brain Injury2.3 Current Pharmacotherapy forßTraumatic Brain Injury; 2.4 Stem Cell Therapy inßTraumatic Brain Injury; 2.4.1 Transplantation ofßExogenous Stem Cells inßTraumatic Brain Injury; 2.4.2 Stimulation ofßEndogenous Neural Precursor Cells inßTraumatic Brain Injury; 2.5 Bench toßBedside Translation ofßStem Cell Therapy inßTraumatic Brain Injury; 2.6 Conclusion; References; Chapter 3: Stem Cells inßAlzheimer's Disease Therapy; 3.1 Introduction; 3.2 Pathogenesis ofßAlzheimer's Disease andßDrug Treatment; 3.3 Animal Models inßAD Therapy withßStem Cells.
3.4 Stem Cells asßaßModel toßStudy AD3.5 The Use ofßStem Cells inßAD Therapy; 3.6 Conclusion; References; Chapter 4: Stem Cell-Based Approaches forßTreatment ofßGlioblastoma; 4.1 Introduction; 4.2 Glioblastoma; 4.2.1 Epidemiology; 4.2.2 Genetic Background; 4.3 Current Treatment Options forßGlioblastoma; 4.3.1 Standard ofßCare; 4.3.2 Molecular Treatment Strategies; 4.3.3 Limitations ofßAvailable Treatments; 4.4 Application ofßStem Cells toßGlioblastoma Therapy; 4.4.1 Rationale forßStem Cell-Based Therapies; 4.4.2 Application ofßStem Cells forßTreatment ofßGlioblastoma; 4.4.3 Immunotoxins.
4.4.4 Suicide Gene Fusion4.4.5 Oncolytic Viruses; 4.4.6 miRNAs; 4.5 Future Directions; 4.5.1 Limitations andßPotential Solutions; 4.5.2 Ethical Concerns; 4.5.3 Concluding Remarks; References; Chapter 5: Stem Cell-Based Therapies forßParkinson's Disease; 5.1 Introduction; 5.2 Grafts ofßHuman Fetal Ventral Mesencephalic Tissue; 5.3 Stem Cell Properties andßRequirements forßTheir Application inßCRT forßPD; 5.4 Multipotent Stem Cells; 5.4.1 Human Neural Stem Cells; 5.4.2 Human Mesenchymal Stem Cells; 5.4.3 Human Pluripotent Stem Cells; 5.4.4 Human Embryonic Stem Cells.
5.4.5 Human Parthenogenetic Embryonic Stem Cells5.4.6 Human Induced Pluripotent Stem Cells; 5.5 Conclusions andßFuture Directions; References; Chapter 6: Mesenchymal Stromal Cell Therapy forßNeonatal Hypoxic-Ischemic Encephalopathy; 6.1 Introduction; 6.2 Mesenchymal Stromal Cells; 6.3 The Therapeutic Efficacy ofßMesenchymal Stromal Cells inßPreclinical Animal Models ofßNeonatal Hypoxia-Ischemia; 6.3.1 Mesenchymal Stromal Cells fromßAdult Tissues; 6.3.2 Mesenchymal Stromal Cells fromßNeonatal Tissues.
2.2.2 Secondary Injury After Traumatic Brain Injury2.3 Current Pharmacotherapy forßTraumatic Brain Injury; 2.4 Stem Cell Therapy inßTraumatic Brain Injury; 2.4.1 Transplantation ofßExogenous Stem Cells inßTraumatic Brain Injury; 2.4.2 Stimulation ofßEndogenous Neural Precursor Cells inßTraumatic Brain Injury; 2.5 Bench toßBedside Translation ofßStem Cell Therapy inßTraumatic Brain Injury; 2.6 Conclusion; References; Chapter 3: Stem Cells inßAlzheimer's Disease Therapy; 3.1 Introduction; 3.2 Pathogenesis ofßAlzheimer's Disease andßDrug Treatment; 3.3 Animal Models inßAD Therapy withßStem Cells.
3.4 Stem Cells asßaßModel toßStudy AD3.5 The Use ofßStem Cells inßAD Therapy; 3.6 Conclusion; References; Chapter 4: Stem Cell-Based Approaches forßTreatment ofßGlioblastoma; 4.1 Introduction; 4.2 Glioblastoma; 4.2.1 Epidemiology; 4.2.2 Genetic Background; 4.3 Current Treatment Options forßGlioblastoma; 4.3.1 Standard ofßCare; 4.3.2 Molecular Treatment Strategies; 4.3.3 Limitations ofßAvailable Treatments; 4.4 Application ofßStem Cells toßGlioblastoma Therapy; 4.4.1 Rationale forßStem Cell-Based Therapies; 4.4.2 Application ofßStem Cells forßTreatment ofßGlioblastoma; 4.4.3 Immunotoxins.
4.4.4 Suicide Gene Fusion4.4.5 Oncolytic Viruses; 4.4.6 miRNAs; 4.5 Future Directions; 4.5.1 Limitations andßPotential Solutions; 4.5.2 Ethical Concerns; 4.5.3 Concluding Remarks; References; Chapter 5: Stem Cell-Based Therapies forßParkinson's Disease; 5.1 Introduction; 5.2 Grafts ofßHuman Fetal Ventral Mesencephalic Tissue; 5.3 Stem Cell Properties andßRequirements forßTheir Application inßCRT forßPD; 5.4 Multipotent Stem Cells; 5.4.1 Human Neural Stem Cells; 5.4.2 Human Mesenchymal Stem Cells; 5.4.3 Human Pluripotent Stem Cells; 5.4.4 Human Embryonic Stem Cells.
5.4.5 Human Parthenogenetic Embryonic Stem Cells5.4.6 Human Induced Pluripotent Stem Cells; 5.5 Conclusions andßFuture Directions; References; Chapter 6: Mesenchymal Stromal Cell Therapy forßNeonatal Hypoxic-Ischemic Encephalopathy; 6.1 Introduction; 6.2 Mesenchymal Stromal Cells; 6.3 The Therapeutic Efficacy ofßMesenchymal Stromal Cells inßPreclinical Animal Models ofßNeonatal Hypoxia-Ischemia; 6.3.1 Mesenchymal Stromal Cells fromßAdult Tissues; 6.3.2 Mesenchymal Stromal Cells fromßNeonatal Tissues.