Preface; Contents; Author Biographies; Emerging Themes in Drug Resistance; 1 Pharmacogenomics; 1.1 Introduction; 1.2 Role of Pharmacogenomics in Drug Resistance; 1.2.1 Tuberculosis; 1.2.2 Epilepsy; 1.2.3 HIV; 1.3 Role of Pharmacogenomics in Drug Discovery; 2 Therapeutic Antibodies for Bacterial Diseases; 2.1 The Growing Problem of Antimicrobial Resistance; 2.2 The Need for New Therapeutic Interventions; 2.3 The Foundations of Antibody Therapy; 2.4 Antibody Structure; 2.5 Types of Therapeutic Antibody Molecules; 2.6 Clinical Pipeline; 2.6.1 Neutralization of Viruses and Toxins

2.6.2 Opsonophagocytic Killing2.6.3 Complement Activation; 2.6.4 Antibody-Drug Conjugates; 2.7 Advantages and Disadvantages of Antibody Therapy; 3 Development of Drug Resistance Through Inter- and Intracellular Communication; 4 Exosome-Mediated Drug Resistance; 4.1 Extracellular Vesicles as Carriers of Drug-Resistant Traits Across Pathologies; 4.2 Vesicle-Mediated Drug Resistance in Noncommunicable Disorders; 4.3 Vesicle-Mediated Drug Resistance in Pathogenic Disorders; 5 Structuromics; 5.1 Role of Structuromics in Deciphering the Drug Resistance Mechanism

5.2 Role of Structuromics in Drug Designing6 Posttranslationally Modified Protein Networks as Drug Targets; 7 Conclusions; References; Molecular Mechanism of Drug Resistance: Common Themes; 1 Introduction; 2 Mechanisms of Drug Resistance; 2.1 Intrinsic Resistance; 2.2 Acquired Resistance; 2.2.1 Diminution of Intracellular Antibiotic Load: The External Affairs; 2.2.1.1 Reducing Permeability: The Consular Affairs; 2.2.1.2 Enhancing the Efflux: The Deporting Mechanisms; 2.2.2 Modification of the Target: The Blacking Out; 2.2.2.1 Mutation of the Target

2.2.2.2 Protection or Modification of the Target2.2.3 Neutralization of the Antibiotic: Warhead Destruction; 2.2.3.1 Hydrolytic Cleavage of the Antibiotic; 2.2.3.2 Addition of Functional Group; 3 Multi-, Extreme- and Pan-Drug Resistance: The Current Threats; 4 Conclusions and Future Perspectives; References; Molecular Mechanism of Drug Resistance; 1 Introduction; 2 Emergence of Drug Resistance: The Road So Far; 2.1 History of Antibiotic Resistance Development: A Problem Getting Worse; 3 Factors for Drug Resistance Development: The Ongoing Phenomena; 4 General Mechanism of Drug Resistance

4.1 Intrinsic Resistance4.2 Acquired Resistance; 5 Drug Resistance Mechanism (Disease Specific); 5.1 Tumor Drug Resistance: An Evolving Paradigm; 5.2 Antibiotic Resistance: The Bacterial Weapons; 5.2.1 Survival Strategies; 5.2.2 Antibiotic Efflux Pump System; 5.2.3 Degradation of Antibiotic; 5.2.4 Alteration of Bacterial Target; 5.3 Tuberculosis: The Unsolved Puzzle; 5.4 Antifungal Drug Resistance; 5.4.1 Antifungal Agents and Their Mechanism of Action; 5.4.2 Ergosterol Biosynthesis Inhibitors (Azoles and Triazoles); 5.4.3 Polyenes; 5.4.4 5-Fluorocytosine: Nucleic Acid Synthesis Inhibitors