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Preface; Contents; 47 Current Concept of IgG4-Related Disease; Abstract; 1 The History of IgG4-Related Disease: Before and After Discovery of IgG4 (Table 1); 2 Current Concepts of IgG4-RD; 3 Nomenclatures and Individual Organ Manifestation of IgG4-RD; 3.1 Type 1 Autoimmune Pancreatitis (IgG4-Related Pancreatitis); 3.2 IgG4-Related Sclerosing Cholangitis (IgG4-SC); 3.3 IgG4-Related Dacryoadenitis and Sialoadenitis (Formerly Called Mikulicz's Disease); 3.4 IgG4-Related Ophthalmic Diseases (IgG4-Related OD); 3.5 IgG4-Related Kidney Disease (IgG4-Related KD)
3.6 IgG4-Related Retroperitoneal Fibrosis (IgG4-Related RPF)3.7 IgG4-Related Pulmonary Diseases (IgG4-Related PD); 3.8 IgG4-Related Thyroid Disease; 3.9 IgG4-Related Aortitis/Periaortitis; 3.10 IgG4-Related Lymphadenopathy; Acknowledgment; References; 36 Diagnosis and Treatment of IgG4-Related Disease; Abstract; 1 Introduction; 2 Diagnosis; 2.1 Epidemiology; 2.2 Clinical Symptoms; 2.3 Laboratory Tests; 2.4 Imaging; 2.5 Histopathology; 2.6 Steroid Responsiveness; 2.7 Diagnostic Criteria; 3 Treatment; 3.1 Indication of Treatment; 3.2 Induction of Remission; 3.3 Relapse and Maintenance Therapy
3.4 Treatment-Related Side Effects4 Prognosis; 5 Future Perspectives; References; 37 Immunogenetics of IgG4-Related AIP; Abstract; 1 Introduction; 2 Association Studies Using Polymorphic Markers in Candidate Genes; 2.1 Human Leukocyte Antigen (HLA) Complex; 2.2 Fc Receptor-Like 3 (FCRL3) Gene; 2.3 Cytotoxic T-Lymphocyte Antigen-4 (CTLA-4; CD152) Gene; 2.4 Toll-Like Receptor 4 (TLR4) and Protein Tyrosine Phosphatase N22 (PTPN22) Genes; 3 Association Studies Using Genome-Wide Polymorphic Markers; 3.1 Microsatellite Markers
3.2 Small-Scale GWAS for Detecting Genetic Factors Causing the Development of Lachrymal/Salivary Gland Lesions in AIP4 Conclusions and Future Perspectives; References; 38 The Histopathology of IgG4-Related Disease; Abstract; 1 Diagnosis of IgG4-Related Disease; 2 General Pathological Features of IgG4-RD; 2.1 Morphological Features; 2.2 Immunohistochemical Features; 3 Proposed Diagnostic Terminology for IgG4-RD; 4 Pancreatobiliary Manifestations; 5 Sialadenitis and Dacryoadenitis; 6 Lung Disease; 7 Periaortitis, Inflammatory Aneurysm, and Retroperitoneal Fibrosis; 8 Lymphadenopathy; 9 Summary
3.6 IgG4-Related Retroperitoneal Fibrosis (IgG4-Related RPF)3.7 IgG4-Related Pulmonary Diseases (IgG4-Related PD); 3.8 IgG4-Related Thyroid Disease; 3.9 IgG4-Related Aortitis/Periaortitis; 3.10 IgG4-Related Lymphadenopathy; Acknowledgment; References; 36 Diagnosis and Treatment of IgG4-Related Disease; Abstract; 1 Introduction; 2 Diagnosis; 2.1 Epidemiology; 2.2 Clinical Symptoms; 2.3 Laboratory Tests; 2.4 Imaging; 2.5 Histopathology; 2.6 Steroid Responsiveness; 2.7 Diagnostic Criteria; 3 Treatment; 3.1 Indication of Treatment; 3.2 Induction of Remission; 3.3 Relapse and Maintenance Therapy
3.4 Treatment-Related Side Effects4 Prognosis; 5 Future Perspectives; References; 37 Immunogenetics of IgG4-Related AIP; Abstract; 1 Introduction; 2 Association Studies Using Polymorphic Markers in Candidate Genes; 2.1 Human Leukocyte Antigen (HLA) Complex; 2.2 Fc Receptor-Like 3 (FCRL3) Gene; 2.3 Cytotoxic T-Lymphocyte Antigen-4 (CTLA-4; CD152) Gene; 2.4 Toll-Like Receptor 4 (TLR4) and Protein Tyrosine Phosphatase N22 (PTPN22) Genes; 3 Association Studies Using Genome-Wide Polymorphic Markers; 3.1 Microsatellite Markers
3.2 Small-Scale GWAS for Detecting Genetic Factors Causing the Development of Lachrymal/Salivary Gland Lesions in AIP4 Conclusions and Future Perspectives; References; 38 The Histopathology of IgG4-Related Disease; Abstract; 1 Diagnosis of IgG4-Related Disease; 2 General Pathological Features of IgG4-RD; 2.1 Morphological Features; 2.2 Immunohistochemical Features; 3 Proposed Diagnostic Terminology for IgG4-RD; 4 Pancreatobiliary Manifestations; 5 Sialadenitis and Dacryoadenitis; 6 Lung Disease; 7 Periaortitis, Inflammatory Aneurysm, and Retroperitoneal Fibrosis; 8 Lymphadenopathy; 9 Summary