Preface; Contents; Aggregation of FET Proteins as a Pathological Change in Amyotrophic Lateral Sclerosis; 1 Introduction; 2 Structure and Physiological Functions of FET Proteins; 3 Pathological Inclusions Containing FET Proteins in ALS Cases; 4 In vitro Aggregation of Recombinant FET Proteins; 5 Concluding Remarks; References; Structural Changes Fundamental to Gating of the Cystic Fibrosis Transmembrane Conductance Regulator Anion Channel Pore; 1 Introduction: Cystic Fibrosis and CFTR; 2 Understanding the Transport Mechanism in CFTR
A Channel Derived from a Pump

3 The Structure and Function of the CFTR Anion Channel4 CFTR Channel Gating; 5 Inferring the Structural Rearrangements During Gating; 5.1 Global Structure of the Pore; 5.2 Location of the Channel Gate(s); 5.3 What Kinds of Movements Do the MSDs Undergo During Gating?; 5.4 Effect of Mutations on Channel Gating; 6 How Can the Conformation of the Channel Pore Be Manipulated to Control CFTR Activity?; 7 Conclusions and Future Perspectives; References; Dual Roles for Epithelial Splicing Regulatory Proteins 1 (ESRP1) and 2 (ESRP2) in Cancer Progression

1 ESRP1 and ESRP2: Splicing Regulatory Proteins Specifically Expressed in Epithelial Cells2 ESRP Expression Is Upregulated in Cancer Cells; 3 ESRPs Negatively Regulate Cell Motility Through Multiple Mechanisms; 4 Dual Roles of ESRPs on Cancer Progression; 5 Possible Functional Differences Between ESRP1 and ESRP2; 6 Concluding Remarks; References; Controlling Autolysis During Flagella Insertion in Gram-Negative Bacteria; 1 Introduction; 2 Bacterial Flagellum Biosynthesis; 3 Peptidoglycan Degrading Enzymes; 3.1 Role in Flagella Assembly; 3.2 beta-N-Acetylglucosaminidases; 3.2.1 Families

3.2.2 Mechanism of Action3.3 Lytic Transglycosylases; 3.3.1 Families; 3.3.2 Mechanism of Action; 4 Modulation of Flagella-Specific Autolysins; 4.1 Control of Autolysins at the Enzyme Level; 4.2 Control and Modulation of Flagella-Specific Autolytic Activity; 5 Concluding Remarks; References; Regulation of Skeletal Muscle Myoblast Differentiation and Proliferation by Pannexins; 1 Pannexins; 2 Pannexin Expression in Skeletal Muscle; 3 Post-translational Modifications of Panx1 and Panx3; 3.1 Glycosylation; 3.2 Phosphorylation; 3.3 Caspase Cleavage; 3.4 S-Nitrosylation

4 Skeletal Muscle Myogenesis and Regeneration4.1 Panx1 Channels Mediate the Acquisition of Myogenic Commitment; 4.2 Panx1 Channels Promote Skeletal Muscle Myoblast Differentiation and Fusion; 4.3 Panx3 Channels Regulate the Proliferation, Differentiation, and Fusion of Skeletal Muscle Myoblasts; 5 Pannexins in Skeletal Muscle Health and Disease; 6 Concluding Remarks; References; Hyaluronidase and Chondroitinase; 1 Glycosaminoglycans; 2 CS/DS and HA-Degrading Enzymes; 2.1 Hyaluronidases (HAases); 2.1.1 Endo-beta-N-Acetylhexosaminidase; 2.1.2 Endo-beta-D-Glucuronidase; 2.1.3 HA Lyase