Proteases in human diseases / Sajal Chakraborti, Tapati Chakraborti, Naranjan S. Dhalla, editors.
Chakraborti, Sajal.; Chakraborti, Tapati.; Dhalla, Naranjan S.
2017
QP609.P78
Available Online

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Title Proteases in human diseases / Sajal Chakraborti, Tapati Chakraborti, Naranjan S. Dhalla, editors.
ISBN 9789811031625 (electronic book)
9811031622 (electronic book)
9811031614
9789811031618
Publication Details Singapore : Springer, 2017.
Language English
Description 1 online resource : illustrations.
Call Number QP609.P78
Dewey Decimal Classification 572/.76
Summary This book bridges the gap between fundamental research and biomedical and pharmacological applications on proteases. It represents a comprehensive overview of the multifaceted field of proteases in cellular environment and highlights the recently elucidated functions of complex proteolytic systems in different diseases. Several established investigators have elucidated the crucial role of proteases in biological processes, including how proteolytic function and regulation can be combined to develop new strategies of therapeutic interventions. Proteases form one of the largest and most diverse families of enzymes known. It is now clear that proteases are involved in every aspect of life functions of an organism. Under physiological conditions, proteases are regulated by their endogenous inhibitors; however, when the activity of proteases is not regulated appropriately, disease processes can result in. So, there is absolute need for a stringent control of proteolytic activities in cells and tissues. Dysregulation of proteases may cause derangement of cellular signalling network resulting in different pathophysiological conditions such as vascular remodelling, atherosclerotic plaque progression, ulcer and rheumatoid arthritis, Alzheimer disease, cancer metastasis, tumor progression and inflammation. Additionally, many infective microorganisms require proteases for replication or use proteases as virulence factors, which have facilitated the development of protease-targeted therapies for a variety of parasitic diseases.
Bibliography, etc. Note Includes bibliographical references.
Access Note Access limited to authorized users.
Source of Description Description based on print version record.
Added Author Chakraborti, Sajal.
Chakraborti, Tapati.
Dhalla, Naranjan S.
Available in Other Form Print version: 9789811031618
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Record Appears in Online Resources > Ebooks
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1. Matrix metalloproteases in breast carcinoma, immunohistology and prognosis
2. Matrix metalloproteases in parasite infection
3. Cysteine cathepsins: In health and rheumatoid arthritis
4. Protective role of antiproteases in radiation induced damage
5. Role of proteases in the regulation of N-myristoyltransferase
6. Proteases in cancer: Potential therapeutic targets
7. MMPs in oral squamous cell carcinoma
8. Caspase regulatory mechanisms: Implications in pathogenesis and therapeutics
9. Physiological and pathological functions of mitochondrial proteases
10. Proteases of parasitic helminths: their metabolic role in establishment of infection in the host
11. Cysteine proteases of parasitic helminths
12. targeting proteases in urine for bladder cancer diagnosis
13. Intramembrane cleaving proteases (ICLiPs), particularly the gamma secretase protease and its role in neurodegeneration, cancer and innate immune signalling
14. Contribution of matrix metalloproteases in cardiovascular diseases
15. OPG/RANKL-protease axis in cardiometabolic diseases
16. Proteases and protease inhibitors in male reproduction
17. The role of MMP-2 and -9 in embryonic neural crest cells and their derivatives
18. Proteolytic ubiquitin like proteins
19. C.albicans aspartic proteases: role of these enzymes in degradation of crucial human host proteins at the place of infection and a possible implications of the protease action for propagation of infection.
20. MMPs in cancer
21. Pathophysiological roles played by proteases of Psedomonas aeruginosa: crucial multifunctional molecules involved in the host infection
22. Role of proteases on activating cell death pathways
23. varying faces of matrix metalloproteinases in cardiovascular diseases
24. kallikreins and kallikrein related peptides (KLKs) in health and disease
25. Endogenous proteases in tumoral progression.

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