Foreword; Contents; Contributors; 1: Basic Electrophysiology; Introduction; The Cardiac Action Potential; What Is an Action Potential? (AP); How Is the Cardiac AP Generated?; Membrane Potential, Equilibrium Potential and Driving Force; Channel Gating; Stages of the Cardiac AP; Phase 4: the Resting Membrane Potential; Phase 0: The Rapid Upstroke; Phase 1: Early Repolarization; Phase 2: The AP Plateau; Phase 3: Repolarization; Contraction of Cardiac Myocytes; Ca2+-Induced Ca2+ Release; Excitation-Contraction Coupling; Automaticity: The Cardiac Pacemakers

The Membrane Clock Model The Ca2+ Clock Model; Other Currents; Cardiac Conduction; Cell-Cell Coupling; Arrhythmogenesis; Abnormal Automaticity; Afterdepolarizations and Triggered Activity; Early Afterdepolarizations (EADs); Delayed Afterdepolarizations (DADs); Reentry; Anatomical Reentry; Functional Reentry; References; 2: Pathophysiology of Atrial Fibrillation; Introduction; Conditions and Diseases That Affect AF Generation; Pathophysiology of AF Initiation: Triggers and Substrate; Pathophysiology of AF Maintenance: Atrial Electrical and Structural Remodeling

Atrial Electrical Remodeling Atrial Structural Remodeling; Is There a "Vulnerable Window" for Development of AF in the Spectrum of Atrial Structural Remodeling?; Electrophysiological Mechanisms of AF: Focal and Reentry; References; 3: Genomics of Cardiac Arrhythmias; DNA Variants; Conventional Approaches to Finding Genes in Familial Traits; Contemporary Approaches to Finding Trait Associated Genetic Variation; The Genome-Wide Association Study; Specific Arrhythmias: Atrial Fibrillation; Specific Arrhythmias: Sudden Cardiac Death

Specific Arrhythmias: Drug-Induced Torsades de Pointes Antiarrhythmic Drug Pharmacogenetics; Summary and Cautionary Notes; References; 4: Channelopathies: Clinical Presentation and Genetics; Long QT Syndrome (LQTS); Clinical Presentation of LQTS; Genetic Basis and Genotype-Phenotype Correlations; Risk Stratification in LQTS; Brugada Syndrome (BrS); Clinical Presentation of BrS; Genetic Basis and Genotype-Phenotype Correlations; Risk Stratification in BrS; Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT); Clinical Presentation of CPVT

Genetic Basis and Genotype-Phenotype Correlations of CPVT Risk Stratification in CPVT; References; 5: Extended ECG Monitoring; Introduction; Recording Systems for Extended Rhythm Monitoring; Holter-ECG; External Cardiac Event Recorders; Implantable Cardiac Monitors (ICMs); Clinical Applications of Non-invasive ECG Monitoring; Atrial Fibrillation and Cryptogenic Stroke; AF Burden Directing Medical or Invasive Management; Palpitations and Unknown Arrhythmia; Unexplained Syncope and Vasovagal Syncope; Screening for Ventricular Arrhythmia and Risk Assessment of Sudden Cardiac Death