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Contributors; Chapter 1: What Can and Should Be the Role of Intervention Studies in GEX Research?; Gene-Environmental Transaction Framework for Intervention Research; References; Part I: Gene-Environment Transaction Framework; Chapter 2: Genetics, Behavioral Intervention, and Human Development; Defining Targets for Behavioral Intervention; Defining Groups of Individuals at Risk for Disease; Delineating Malleable Mechanisms of Gene Expression; Defining the Timing of Behavioral Interventions; Genetic Influences on Response to Treatment; A Few Ideas About the Future; Summary.
Prospects for Detecting G?E in Intervention ResearchReferences; Chapter 4: Epigenetics and the Biology of Gene? Environment Interactions; Epigenetics and the Biological Basis of G? E Interactions; Histone Modifications; DNA Methylation; Epigenetics and Development; Epigenetics and the Biology of G? E Interactions; Epigenetic Regulation of GR Expression and Function in Humans; Environmental Regulation of the Human Methylome; The Epigenome as a Function of Gene? Environment Interactions: Allele-Specific Methylation; Gene x Environment Effects: Plasticity Genes?
Implications for Prevention Programmes Conclusions; References; Chapter 5: Using Genetically Informed Designs to Understand the Environment: The Importance of Family-Based Approaches; Family-Based Behavioral Genetic Designs; Challenges to Family-Based Behavioral Genetic Designs; Conceptual Issues; Technical Issues; The Continued Value of Family-Based Behavioral Genetic Designs; Response to Conceptual Criticisms; Response to Technical Criticisms; The Value of Family-Based Behavioral Genetic Studies; The Implications of Family-Based Behavioral Genetic Studies on Intervention Science.
Conclusions and Future DirectionsReferences; Chapter 6: Gene-Environment Correlation as a Source of Stability and Diversity in Development; A Brief but Successful Baseball Career; If Monkeys Could Play Baseball; Plomin, Loehlin and DeFries (1977); Heritability Increases with Age; The Question of How; Tucker-Drob and Briley; Phenotype to Environment Transmission and Gene-Environment Correlation; Applications to Childhood Intervention; Back to Baseball; References; Chapter 7: Sampling in the Examination of Gene-ƯEnvironmental Interactions Within a Neurodevelopmental Disorder Framework.
Prospects for Detecting G?E in Intervention ResearchReferences; Chapter 4: Epigenetics and the Biology of Gene? Environment Interactions; Epigenetics and the Biological Basis of G? E Interactions; Histone Modifications; DNA Methylation; Epigenetics and Development; Epigenetics and the Biology of G? E Interactions; Epigenetic Regulation of GR Expression and Function in Humans; Environmental Regulation of the Human Methylome; The Epigenome as a Function of Gene? Environment Interactions: Allele-Specific Methylation; Gene x Environment Effects: Plasticity Genes?
Implications for Prevention Programmes Conclusions; References; Chapter 5: Using Genetically Informed Designs to Understand the Environment: The Importance of Family-Based Approaches; Family-Based Behavioral Genetic Designs; Challenges to Family-Based Behavioral Genetic Designs; Conceptual Issues; Technical Issues; The Continued Value of Family-Based Behavioral Genetic Designs; Response to Conceptual Criticisms; Response to Technical Criticisms; The Value of Family-Based Behavioral Genetic Studies; The Implications of Family-Based Behavioral Genetic Studies on Intervention Science.
Conclusions and Future DirectionsReferences; Chapter 6: Gene-Environment Correlation as a Source of Stability and Diversity in Development; A Brief but Successful Baseball Career; If Monkeys Could Play Baseball; Plomin, Loehlin and DeFries (1977); Heritability Increases with Age; The Question of How; Tucker-Drob and Briley; Phenotype to Environment Transmission and Gene-Environment Correlation; Applications to Childhood Intervention; Back to Baseball; References; Chapter 7: Sampling in the Examination of Gene-ƯEnvironmental Interactions Within a Neurodevelopmental Disorder Framework.