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Table of Contents
Intro; Preface; Contents; 1 Nanopore Membranes for Separation and Sensing; Abstract; 1 Introduction; 2 Hindered Transport; 3 Different Types of Nanopore Membranes; 3.1 Track-Etched Membranes; 3.2 Aluminum Anodic Oxide Membranes; 3.3 Template-Synthesized Membranes; 3.4 Silicon and Silicon Nitride Membranes; 4 Functionalized Membranes; 4.1 Polymer Functionalization; 4.1.1 Smart Membranes; 5 Biomolecule Separation Using Nanopore Membranes; 5.1 Separation Using Template-Synthesized Membranes; 5.2 Separation Using Thin Silicon Membranes; 6 Membranes Used as Biosensors; 6.1 Electrical Techniques
6.2 Optical Techniques6.2.1 Plasmonic Nanopores; 6.2.2 Other Optical Measurements; 7 Conclusion and Outlook; References; 2 Nanoporous Gold Nanoparticles and Arrays for Label-Free Nanoplasmonic Biosensing; 1 Introduction; 2 Nanoporous Gold Disks Fabrication and Characterization; 2.1 Nanosphere Lithography and Dealloying of Au/Ag Films; 2.2 Size and Porosity Characterization; 2.3 In-Plane Dealloying; 2.4 In Situ Laser-Assisted Dealloying; 2.5 Integration of the NPG Disks into a Microfluidic Device; 3 Optical Properties of NPG Disks
3.1 Localized Surface Plasmon Resonances of NPG Disks and Their Size-Dependent Tunability3.1.1 Extinction Spectra and LSPR Peaks; 3.1.2 Electric Field Distribution and Localized Field Enhancement; 3.1.3 Local Field Enhancement for SERS; 3.2 Refractive Index Sensitivity of NPG Disks LSPR; 4 Nanoporous Gold Disk Arrays in Microfluidic Sensing Applications; 4.1 Microfluidic SERS Sensor with Monolithic NPG Disks Arrays for Rapid and Label-Free Dopamine and Urea Detection; 4.1.1 Characterization of the Spatial Uniformity and Sensitivity of the Microfluidic SERS Sensor with no Flow
4.1.2 SERS Detection of Rhodamine 6G with Continuous Flow4.1.3 SERS Detection of Dopamine and Urea; 4.1.4 SERS Detection of Urea at Physiological Concentrations; 4.2 In Situ SERS Monitoring of Individual DNA Hybridization in Microfluidics; 4.2.1 SERS Detection of Immobilized MS Probes; 4.2.2 In Situ Monitoring of DNA Hybridization with Varying Target ssDNA Concentrations; 4.2.3 In Situ Monitoring of DNA Hybridization with 20Â pM Target ssDNA Concentration; 5 Versatility and Performance: Nanoporous Gold Disk Arrays in Various Biomolecular Sensing Applications
5.1 Reagent and Separation-Free Measurements of Urine and Creatinine Concentration by Stamping SERS on NPG Disks Arrays5.1.1 Stamping of the Analyte onto the SERS Substrate; 5.1.2 SERS Detection of Creatinine in Water and Multiplexed SERS Concentration Measurements; 5.1.3 SERS Detection of Creatinine in Nephritic Mouse Urine Samples; 5.2 NPG Disks Functionalized with G-Quadruplex Moieties for Sensing Small Molecules; 5.2.1 Design of the Label-Free SERS Sensing Platform; 5.2.2 Sensitivity for MG Detection; 5.2.3 Sensor Performance in Complex Samples and Real-World Situations
6.2 Optical Techniques6.2.1 Plasmonic Nanopores; 6.2.2 Other Optical Measurements; 7 Conclusion and Outlook; References; 2 Nanoporous Gold Nanoparticles and Arrays for Label-Free Nanoplasmonic Biosensing; 1 Introduction; 2 Nanoporous Gold Disks Fabrication and Characterization; 2.1 Nanosphere Lithography and Dealloying of Au/Ag Films; 2.2 Size and Porosity Characterization; 2.3 In-Plane Dealloying; 2.4 In Situ Laser-Assisted Dealloying; 2.5 Integration of the NPG Disks into a Microfluidic Device; 3 Optical Properties of NPG Disks
3.1 Localized Surface Plasmon Resonances of NPG Disks and Their Size-Dependent Tunability3.1.1 Extinction Spectra and LSPR Peaks; 3.1.2 Electric Field Distribution and Localized Field Enhancement; 3.1.3 Local Field Enhancement for SERS; 3.2 Refractive Index Sensitivity of NPG Disks LSPR; 4 Nanoporous Gold Disk Arrays in Microfluidic Sensing Applications; 4.1 Microfluidic SERS Sensor with Monolithic NPG Disks Arrays for Rapid and Label-Free Dopamine and Urea Detection; 4.1.1 Characterization of the Spatial Uniformity and Sensitivity of the Microfluidic SERS Sensor with no Flow
4.1.2 SERS Detection of Rhodamine 6G with Continuous Flow4.1.3 SERS Detection of Dopamine and Urea; 4.1.4 SERS Detection of Urea at Physiological Concentrations; 4.2 In Situ SERS Monitoring of Individual DNA Hybridization in Microfluidics; 4.2.1 SERS Detection of Immobilized MS Probes; 4.2.2 In Situ Monitoring of DNA Hybridization with Varying Target ssDNA Concentrations; 4.2.3 In Situ Monitoring of DNA Hybridization with 20Â pM Target ssDNA Concentration; 5 Versatility and Performance: Nanoporous Gold Disk Arrays in Various Biomolecular Sensing Applications
5.1 Reagent and Separation-Free Measurements of Urine and Creatinine Concentration by Stamping SERS on NPG Disks Arrays5.1.1 Stamping of the Analyte onto the SERS Substrate; 5.1.2 SERS Detection of Creatinine in Water and Multiplexed SERS Concentration Measurements; 5.1.3 SERS Detection of Creatinine in Nephritic Mouse Urine Samples; 5.2 NPG Disks Functionalized with G-Quadruplex Moieties for Sensing Small Molecules; 5.2.1 Design of the Label-Free SERS Sensing Platform; 5.2.2 Sensitivity for MG Detection; 5.2.3 Sensor Performance in Complex Samples and Real-World Situations