Alternatives for dermal toxicity testing / Chantra Eskes, Erwin van Vliet, Howard I. Maibach, editors ; foreword by Alan M. Goldberg.
Eskes, Chantra, editor.; Vliet, Erwin van, editor.; Maibach, Howard I., editor.; Goldberg, Alan M., editor.
2017
RA1199
Available Online

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Title Alternatives for dermal toxicity testing / Chantra Eskes, Erwin van Vliet, Howard I. Maibach, editors ; foreword by Alan M. Goldberg.
ISBN 9783319503530 (electronic book)
3319503537 (electronic book)
9783319503516
3319503510
DOI https://doi.org/10.1007/978-3-319-50353-0
Publication Details Cham : Springer, 2017.
Language English
Description 1 online resource
Other Standard Identifiers 10.1007/978-3-319-50353-0
Call Number RA1199
Dewey Decimal Classification 615.907
Summary This book provides comprehensive information on the alternative (non-animal) dermal toxicity test methods currently available for industrial, regulatory, and academic use and also explores potential future developments. It encompasses all areas of dermal toxicity, including skin irritation, skin corrosion, skin sensitization, UV-induced effects, and skin genotoxicity. An individual chapter is devoted to each test method, with coverage of the scientific basis, validation status and regulatory acceptance, applications and limitations, available protocols, and potential role within testing strategies. In addition, perspectives from the test developer are presented, for example regarding critical steps in the protocol, possible adaptations, and challenges and opportunities. The closing section addresses exploratory areas that may be of relevance for the future of dermal toxicity safety testing, including the validation and regulatory acceptance of integrated testing strategies, the use of alternative methods for infections and inflammatory diseases, novel complex skin models, and high-throughput screening techniques. Dermal toxicity is an area in which alternatives to the use of animal testing have already gained scientific, industrial, and regulatory acceptance. Practitioners and researchers alike will find Alternatives for Dermal Toxicity Testing to be an ideal source of reliable, up-to-date information on all aspects of the available test methods and likely future directions.
Access Note Access limited to authorized users.
Digital File Characteristics text file PDF
Source of Description Online resource; title from PDF title page (viewed November 30, 2017).
Added Author Eskes, Chantra, editor.
Vliet, Erwin van, editor.
Maibach, Howard I., editor.
Goldberg, Alan M., editor.
Available in Other Form Print version: 9783319503516
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Introduction
Concepts
Skin irritation
Skin corrosion
Skin sensitization
UV-induced effects (phototoxicity & photoallergy)
Skin genotoxicity
Other exploratory areas of relevance.

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