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Table of Contents
Intro; Foreword; T4SS-Then and Now; Contents; Abbreviations; 1 Biological Diversity and Evolution of Type IV Secretion Systems; Abstract; 1 Introduction: The ABC's of T4SS Classification; 2 Function, Structure, and Diversification of T4ASS and T4BSSs; 2.1 The VirD4 Receptor and Its Role in Substrate Selection; 2.2 The Role of Accessory Factors in Substrate Recruitment; 2.3 The Inner Membrane Complex (IMC); 2.4 Evolutionary Adaptations of IMC Subunits; 2.5 The Outer Membrane Core Complex (OMCC); 2.6 Evolutionary Adaptations of OMCC Subunits; 3 T4SS-Mediated Modulation of Target Cell Attachment
3.1 T4ASS P- and F-pili3.2 Evolutionary Adaptations of T4ASS-Associated Surface Structures; 3.3 T4BSS DNA Transfer and Dot/Icm Systems; 4 Evolution of Dot/Icm Secretion System; 5 Comparisons of Effectors Secreted Through Different Dot/Icm Secretion Systems; 6 Concluding Remarks; Acknowledgements; References; 2 Structural and Molecular Biology of Type IV Secretion Systems; Abstract; 1 Architectures and Functions of Type IV Secretion Systems; 1.1 Classification and Overview; 1.2 Composition of T4SSs; 2 Structures of Individual Components; 2.1 ATPases; 2.1.1 VirB11; 2.1.2 VirD4; 2.1.3 VirB4
2.2 Inner Membrane2.2.1 VirB3; 2.2.2 VirB6; 2.2.3 VirB8; 2.3 Outer Membrane and Periplasm; 2.3.1 VirB1; 2.3.2 VirB7 and VirB9; 2.3.3 VirB10; 2.4 Pilus Protein(s); 2.4.1 VirB2; 2.4.2 VirB5; 3 Structures of T4SS Molecular Assemblies; 3.1 The Core (or Outer Membrane) Complex; 3.2 The T4SS3-10 Complex; 3.3 Structure of the Pilus; 4 Mechanism of Substrate Transport; 5 Concluding Remarks; Acknowledgements; References; 3 Prokaryotic Information Games: How and When to Take up and Secrete DNA; Abstract; 1 DNA Secretion by Bacterial Conjugation
1.1 Transfer Competence Development and Heterogeneity of Isogenic Populations1.2 Bistability and Excitability in Genetic Networks; 1.3 Non-stochastic Switching to Transfer Competence; 1.3.1 Cell-to-Cell Signaling and Quorum Sensing; 1.3.2 Environmental Signals; 1.4 Stochastic Switching: No Signals and Rules, just Random Amplification of Noise?; 1.4.1 Bet Hedging in Bacterial Conjugation; 2 Bacterial DNA Uptake Competence and Transport Mechanisms; 2.1 Principles of DNA Uptake; 2.1.1 DNA Uptake via a T4SS-How to Take up DNA?; 2.1.2 Components of the ComB T4SS of Helicobacter pylori
2.1.3 Visualization of DNA Uptake in Single Cells of Helicobacter pylori2.2 Competence Development-When to Take up DNA?; 2.2.1 Decision Making for Competence Development Is Species-Specific; 2.2.2 How Is Competence Limited in a T4SS-Mediated DNA Uptake System?; 3 Concluding Remarks; References; 4 Relaxases and Plasmid Transfer in Gram-Negative Bacteria; Abstract; 1 Biochemistry of Relaxases; 2 Relaxase-DNA Binding; 3 Relaxosome; 4 Intracellular Trafficking and Relaxase Recruitment to the Conjugative Pore; 5 Bifunctional Relaxase-DNA Helicase Enzymes; 6 Domain-Specific DNA Interactions
3.1 T4ASS P- and F-pili3.2 Evolutionary Adaptations of T4ASS-Associated Surface Structures; 3.3 T4BSS DNA Transfer and Dot/Icm Systems; 4 Evolution of Dot/Icm Secretion System; 5 Comparisons of Effectors Secreted Through Different Dot/Icm Secretion Systems; 6 Concluding Remarks; Acknowledgements; References; 2 Structural and Molecular Biology of Type IV Secretion Systems; Abstract; 1 Architectures and Functions of Type IV Secretion Systems; 1.1 Classification and Overview; 1.2 Composition of T4SSs; 2 Structures of Individual Components; 2.1 ATPases; 2.1.1 VirB11; 2.1.2 VirD4; 2.1.3 VirB4
2.2 Inner Membrane2.2.1 VirB3; 2.2.2 VirB6; 2.2.3 VirB8; 2.3 Outer Membrane and Periplasm; 2.3.1 VirB1; 2.3.2 VirB7 and VirB9; 2.3.3 VirB10; 2.4 Pilus Protein(s); 2.4.1 VirB2; 2.4.2 VirB5; 3 Structures of T4SS Molecular Assemblies; 3.1 The Core (or Outer Membrane) Complex; 3.2 The T4SS3-10 Complex; 3.3 Structure of the Pilus; 4 Mechanism of Substrate Transport; 5 Concluding Remarks; Acknowledgements; References; 3 Prokaryotic Information Games: How and When to Take up and Secrete DNA; Abstract; 1 DNA Secretion by Bacterial Conjugation
1.1 Transfer Competence Development and Heterogeneity of Isogenic Populations1.2 Bistability and Excitability in Genetic Networks; 1.3 Non-stochastic Switching to Transfer Competence; 1.3.1 Cell-to-Cell Signaling and Quorum Sensing; 1.3.2 Environmental Signals; 1.4 Stochastic Switching: No Signals and Rules, just Random Amplification of Noise?; 1.4.1 Bet Hedging in Bacterial Conjugation; 2 Bacterial DNA Uptake Competence and Transport Mechanisms; 2.1 Principles of DNA Uptake; 2.1.1 DNA Uptake via a T4SS-How to Take up DNA?; 2.1.2 Components of the ComB T4SS of Helicobacter pylori
2.1.3 Visualization of DNA Uptake in Single Cells of Helicobacter pylori2.2 Competence Development-When to Take up DNA?; 2.2.1 Decision Making for Competence Development Is Species-Specific; 2.2.2 How Is Competence Limited in a T4SS-Mediated DNA Uptake System?; 3 Concluding Remarks; References; 4 Relaxases and Plasmid Transfer in Gram-Negative Bacteria; Abstract; 1 Biochemistry of Relaxases; 2 Relaxase-DNA Binding; 3 Relaxosome; 4 Intracellular Trafficking and Relaxase Recruitment to the Conjugative Pore; 5 Bifunctional Relaxase-DNA Helicase Enzymes; 6 Domain-Specific DNA Interactions