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Intro; Contents; Chapter 1 Introduction; Abstract; 1.1 Building on the Legacy of Russell and Burch (1959/1992); 1.2 Four Movements to the Argument; 1.3 Full Disclosure; References; Chapter 2 Concept Fatigue with the Three R's; Abstract; 2.1 The Original Work by Russell and Burch (1959/1992) in Context; 2.1.1 On the Removal of Inhumanity; 2.1.2 Humane Versus Speciesist; 2.1.3 The Actual Definitions; 2.1.3.1 Replacement; 2.1.3.2 Reduction; 2.1.3.3 Refinement; 2.2 Changing Perspectives on the Use of Animals; 2.2.1 No Magic Dust; 2.2.2 For the Animal's Sake

2.2.3 The Monkey Eye-Movement Paradigm Then and NowReferences; Chapter 3 A Mismatch Between Micro-motives and Macro-behavior; Abstract; 3.1 Analyzing Aggregate Behavior; 3.1.1 Three Classic Examples of Micro-Macro Conflict; 3.1.1.1 The Prisoner's Dilemma; 3.1.1.2 The Tragedy of the Commons; 3.1.1.3 The Case of the Two Dining Rooms; 3.1.2 Applying the Micro-Macro Analysis to Animal Research; 3.1.2.1 The Individual Researcher's Perspective; 3.1.2.2 Failure of the Three R's at the Macroscopic Level; 3.1.2.3 Scale Enlargement for More with Less; 3.1.2.4 Public Support as a Limited Resource

3.2 The Principles of Reasonable Experimental Inquiry3.2.1 On the Valuation of Research; 3.2.2 The Preferred Animal Model; 3.2.3 New Definitions; 3.2.3.1 Replacement; 3.2.3.2 Reduction; 3.2.3.3 Refinement; References; Chapter 4 The Monkey Question; Abstract; 4.1 A Critique of Arguments; 4.1.1 The Past Is Not Always a Good Model for the Future; 4.1.2 Misleading Claims of Necessity; 4.1.3 An Erroneous Preference for Nonhuman Primates; 4.1.4 A Prejudice Against Replacement with Other Animals; 4.2 Examples of (Missed) Replacement Opportunities; 4.2.1 Real-Time Control of a Robot Arm

4.2.2 Perceptual Decision-Making4.2.3 Cognitive Mechanisms of Cocaine Addiction; References; Chapter 5 Toward Reasonable Experimental Inquiry; Abstract; 5.1 Replacement as the Critical R; 5.1.1 Eyes Open to Opportunity Costs; 5.1.2 Real-World Barriers to Replacement; 5.1.3 A Shift in Agency; 5.2 Practical Wisdom, Informed and Integrative; 5.2.1 Open Science; 5.2.2 Big Science; 5.2.3 Free Thought and Coordinated Action; 5.3 The Sleep of Reason Produces Monsters; References; Index

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