Linked e-resources
Details
Table of Contents
Intro; Contents; Chapter 1: Assembly of Nuclear Pore Complex; 1.1 Overview; 1.2 Nups and Subcomplexes of NPCs; 1.3 Assembly of NPCs; 1.3.1 NPC Assembly During Interphase; 1.3.2 Post-Mitotic NPC Assembly; 1.3.3 A Third Pathway for NPC Assembly; 1.4 Regulation of NPC Assembly; 1.5 Conclusions; References; Chapter 2: Structure of Yeast Nuclear Pore Complexes; 2.1 Introduction; 2.1.1 Overall Structure of the NPC; 2.1.2 Difference Between Yeast NPCs and Vertebrate NPCs; 2.2 Stoichiometry of Nups in Yeast NPC; 2.2.1 Recent Progress of the Stoichiometry of Nups by Several Approaches
2.2.2 Stoichiometry of Nups in Living Yeast NPCby a Single Molecular Detection Approach2.3 Dynamics of Nups; 2.4 Perspective; References; Chapter 3: Dynamic Structures of the Nuclear Pore Complex and Their Roles in Nucleocytoplasmic Transport; 3.1 Introduction: The NPC Consists of a Rigid Scaffold and Dynamic Peripheral and Central Structures; 3.2 Structural Composition of Dynamic Components of the Nuclear Pore Complex; 3.2.1 The Cytoplasmic Face; 3.2.1.1 Nup358 Is the Major Component of the Cytoplasmic Filaments
3.2.1.2 Nup214 and Nup88 Are Components of the Cytoplasmic Ring, not the Filaments3.2.1.3 Nup358/Cytoplasmic Filaments Are Anchored to Nup96 and Nup133 of the Y Complex; 3.2.1.4 Nup358 Is a Multidomain Platform; 3.2.1.5 Nup358 Is Dynamic; 3.2.1.6 Yeast and Plants Have Cytoplasmic Filaments but not Nup358; 3.2.2 FG Domains; 3.2.2.1 Cytosol Is Excluded from an FG Domain-Containing Region Around the NPC Entrance; 3.2.2.2 FG Domains Adopt Alternative Conformations; 3.2.2.3 FG Domains May Form Specific but Dynamic Structures; 3.2.2.4 FG Domains Could Form Dynamic Hydrogel Structures
3.2.3 Mapping Transport Routes Suggests the Presence of Defined Central Structures3.2.4 The Nucleoplasmic Face; 3.3 Conclusions; References; Chapter 4: Non-canonical Roles of Nuclear Pore Proteins; 4.1 Introduction: The Nuclear Pore; 4.2 Mitosis: Many Points of Intersection with Nup Function; 4.2.1 Nups and Chromosome Congression; 4.2.2 Nups and Mitotic Spindle Assembly; 4.2.3 Nups and Spindle Assembly Checkpoint Maintenance; 4.2.4 Mitotic Exit and Cytokinesis; 4.3 Regulation of Gene Expression: The Chromatin Landscape and Beyond; 4.4 DNA Damage: Emerging Roles for Nups
4.4.1 Nucleoporins and DNA Repair in Yeast4.4.2 Nucleoporins and DNA Repair in Mammalian Cells; 4.5 Pore Proteins at Cilia: Defining Where, Why, and How; 4.6 The NPC as a Signaling and Tethering Platform; 4.7 Further Considerations and Conclusions; References; Chapter 5: On the Role of the Channel Nucleoporins in Nuclear Transport; 5.1 Overview; 5.2 The Channel Nups Are Essential for Significant Nuclear Transport Rates Through the NPC; 5.3 Structural Characterization of the Channel Nups; 5.3.1 X-Ray Structures of the Channel Nups and Implications for Nuclear Transport
2.2.2 Stoichiometry of Nups in Living Yeast NPCby a Single Molecular Detection Approach2.3 Dynamics of Nups; 2.4 Perspective; References; Chapter 3: Dynamic Structures of the Nuclear Pore Complex and Their Roles in Nucleocytoplasmic Transport; 3.1 Introduction: The NPC Consists of a Rigid Scaffold and Dynamic Peripheral and Central Structures; 3.2 Structural Composition of Dynamic Components of the Nuclear Pore Complex; 3.2.1 The Cytoplasmic Face; 3.2.1.1 Nup358 Is the Major Component of the Cytoplasmic Filaments
3.2.1.2 Nup214 and Nup88 Are Components of the Cytoplasmic Ring, not the Filaments3.2.1.3 Nup358/Cytoplasmic Filaments Are Anchored to Nup96 and Nup133 of the Y Complex; 3.2.1.4 Nup358 Is a Multidomain Platform; 3.2.1.5 Nup358 Is Dynamic; 3.2.1.6 Yeast and Plants Have Cytoplasmic Filaments but not Nup358; 3.2.2 FG Domains; 3.2.2.1 Cytosol Is Excluded from an FG Domain-Containing Region Around the NPC Entrance; 3.2.2.2 FG Domains Adopt Alternative Conformations; 3.2.2.3 FG Domains May Form Specific but Dynamic Structures; 3.2.2.4 FG Domains Could Form Dynamic Hydrogel Structures
3.2.3 Mapping Transport Routes Suggests the Presence of Defined Central Structures3.2.4 The Nucleoplasmic Face; 3.3 Conclusions; References; Chapter 4: Non-canonical Roles of Nuclear Pore Proteins; 4.1 Introduction: The Nuclear Pore; 4.2 Mitosis: Many Points of Intersection with Nup Function; 4.2.1 Nups and Chromosome Congression; 4.2.2 Nups and Mitotic Spindle Assembly; 4.2.3 Nups and Spindle Assembly Checkpoint Maintenance; 4.2.4 Mitotic Exit and Cytokinesis; 4.3 Regulation of Gene Expression: The Chromatin Landscape and Beyond; 4.4 DNA Damage: Emerging Roles for Nups
4.4.1 Nucleoporins and DNA Repair in Yeast4.4.2 Nucleoporins and DNA Repair in Mammalian Cells; 4.5 Pore Proteins at Cilia: Defining Where, Why, and How; 4.6 The NPC as a Signaling and Tethering Platform; 4.7 Further Considerations and Conclusions; References; Chapter 5: On the Role of the Channel Nucleoporins in Nuclear Transport; 5.1 Overview; 5.2 The Channel Nups Are Essential for Significant Nuclear Transport Rates Through the NPC; 5.3 Structural Characterization of the Channel Nups; 5.3.1 X-Ray Structures of the Channel Nups and Implications for Nuclear Transport