Tumor deposits : mechanism, morphology and prognostic implications / Sulen Sarioglu.
Sarioglu, Sulen, author.
2018
RD651
Available Online

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Title Tumor deposits : mechanism, morphology and prognostic implications / Sulen Sarioglu.
Author Sarioglu, Sulen, author.
ISBN 9783319685823 (electronic book)
3319685821 (electronic book)
9783319685816
3319685813
DOI https://doi.org/10.1007/978-3-319-68582-3
Published Cham : Springer, [2018]
Copyright ©2018
Language English
Description 1 online resource
Item Number 10.1007/978-3-319-68582-3 doi
Call Number RD651
Dewey Decimal Classification 616.994
Summary This book presents the morphology, possible mechanisms of formation, and clinical relevance of tumor deposits (TDs) in different organs and parts of the body. It also describes the diagnostic features that are currently available for TDs and discusses the prognostic impact of TDs. The poor prognostic and predictive values of TDs were found to be as strong as distant metastasis in different series. TDs, best characterized by colorectal cancer, are irregular discrete tumor masses that are discontinuous from the leading edge of the tumor. However, even in colorectal cancers, the place of TDs in tumor staging (tumor, lymph node and distant metastasis categories) remains controversial. This book presents the possible mechanisms of TD formation, including neurotrophic and angiotrophic extravascular migratory metastasis, in comparison with the well-known mechanisms of metastasis. It also shows that TDs were identified in esophageal, gastric, salivary gland, head and neck, and breast carcinomas. The possible mechanisms leading to the frequent association of TDs and peritoneal carcinomatosis are discussed. This is a valuable resource for pathologists, oncologists, and surgeons who are looking for detailed information on the latest scientific insights into the pathology and prognostic implications of TDs.
Bibliography, etc. Note Includes bibliographical references and index.
Access Note Access limited to authorized users.
Digital File Characteristics text file PDF
Source of Description Online resource; title from PDF title page (viewed January 15, 2018).
Available in Other Form Tumor deposits.
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Intro; Preface; Acknowledgment; Contents; 1: Mechanisms of Metastasis; Normal Tissue Versus Malignant Neoplasia; Molecular and Genetic Features; Genomic Instability; Metabolic Alterations; Limitless Replicative Potential; Angiogenesis, Vasculogenesis, Vascular Co-option, Lymphangiogenesis, and Neoneurogenesis; Autophagy; Apoptosis, Necroptosis, and Anoikis; Apoptosis; Anoikis; Necroptosis; Proteases: Degradation of the Extratumoral Spaces; Epithelial-Mesenchymal Transition; EMT Regulation; Mesenchymal-Epithelial Transition; EMT, Stem Cells, and Tumor-Initiating Cells; Cell Adhesion.

Tumor-Stroma InteractionsEscape from Immune Surveillance; Metastasis; Tumor Migration; Circulating Tumor Cells; Metastasis Suppressor Genes; Exosomes in Cancer Metastasis; Invasion of the Vessels; Extravasation; Metastatic Colonization, Tumor Dormancy, and Reactivation; Last Words; References; 2: Tumor Deposits; Mechanisms, Morphology, and Differential Diagnosis; Morphology and Differential Diagnosis of Free Tumor Deposits; Clinical Relevance of Free Tumor Deposits; Mechanisms of Tumor Deposit Formation.

Neurotrophic Extravascular Migratory Metastasis, Perineural Invasion, and Perineural-Type Tumor Deposit FormationAngiotrophic Extravascular Migratory Metastasis and Perivascular-Type Tumor Deposit Formation; Tumor Deposits Associated with Lymphatics; Other Routes of Tumor Spread; References; 3: Tumor Deposits in Colorectal Cancer; Prognostic Factors in Colorectal Carcinomas; Proposed Mechanisms and Morphology of TDs in Colorectal Carcinomas; Classifications of TDs in Colorectal Carcinomas; Prognostic Studies on Tumor Deposits in Colorectal Carcinomas.

Discussion About TDs in Colorectal CarcinomasNeoadjuvant Radiotherapy and Tumor Deposits; References; 4: Tumor Deposits in Gastric Cancer; Morphologic and Molecular Classifications of the Gastric Carcinomas and Prognostic Features; EBV-Associated DNA Hypermethylation; Microsatellite Instability; Genomically Stable Tumors; Chromosomally Unstable Tumors; Prognostic Factors in Gastric Carcinomas; HER2: A Predictive Biomarker in Gastric Carcinoma; Trastuzumab for Gastric Cancer (ToGA Trial) (Bang YJ 2010); Methods for Evaluation of HER2 Amplification; Immunohistochemistry.

In Situ HybridizationThe Diagnostic Combination of IHC and ISH for HER2 Amplification; The Incidence of HER2 Amplification in Gastric and Gastroesophageal Carcinoma Cases; Implications for Treatment; Proposed Mechanisms and Morphology of Tumor Deposits in Gastric Carcinomas; Classifications of Tumor Deposits in Gastric Carcinomas; Prognostic Studies on Tumor Deposits in Gastric Carcinomas; Discussion About TDs in Gastric Carcinomas; References; 5: Tumor Deposits in Esophageal Carcinomas; Morphologic and Molecular Classifications of the Esophageal Carcinomas.

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