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Table of Contents
Intro; Preface; Contents; 1: Translational Research in the Oral Health Sciences; 1.1 Definition of Translational Research in the Biomedical Sciences; 1.2 What Is Needed to Carry Out Biomedical Translational Research?; 1.2.1 Graduate Student Training; 1.2.2 Publication of Translational Team Science Research; 1.2.3 The Role of the Institution; References; 2: How Cross-Disciplinary Research Has Increased Our Understanding of Oral Mucosal Diseases; 2.1 Introduction; 2.2 What Is Research in Medical and Dental Schools?; 2.3 Multidisciplinary Clinics.
2.4 Assessment of Disease Severity and Treatment Responses in Oral Mucosal Disease2.5 Bullous Diseases; 2.6 Orofacial Granulomatosis; 2.7 Sjögren's Syndrome Clinic; 2.8 Clinical Oral Dryness Score (Fig. 2.7); References; 3: Epigenetics and Periodontitis: A Source of Connection to Systemic Diseases; 3.1 Introduction; 3.1.1 Molecular Regulation of the Immune Response; 3.1.2 Epigenetic Modifications of Gene Expression; 3.1.3 Immune Response in Periodontitis and Epigenetic Modifications; 3.1.4 DNA Methylation, Histone Modulation, and Other Gene Alterations; 3.2 Role of MicroRNAs.
3.3 Role of Long Noncoding RNAs3.4 Periodontitis, Epigenetic Alterations, and Systemic Diseases; 3.4.1 Obesity; 3.4.2 Cardiovascular Disease; 3.4.3 Rheumatoid Arthritis; 3.4.4 Cancer; 3.5 Concluding Remarks; References; 4: Topic: aMMP-8 Oral Fluid PoC Test; 4.1 Introduction; 4.2 Periodontal Health Versus Periodontal Inflammation and Clinical Measuring; 4.3 Validity, Sensitivity, and Specificity of Neutrophil Collagenase-2 (aMMP-8) System; 4.4 Justification for aMMP-8 Chairside Test in Reproductive Health Parameters.
4.5 Effect of Chronic Periodontitis on Erectile Dysfunction and Sperm Count4.6 Association Between Periodontitis and Conception; 4.7 Emerging Racial Differences on Chronic Periodontitis and Pregnancy Outcomes; 4.8 Role of aMMP-8 Chairside Test in Specific Periodontal Health Parameters; References; 5: Composite Biomaterials: From Lab to Clinics; 5.1 Introduction; 5.2 Dental Applications for FRC; 5.3 All Started from Removable Dentures; 5.4 Next Step: Fixed Dental Prostheses; 5.5 Into the Root Canal; 5.6 To Replace Amalgam; 5.7 Into Bone: Surgical Applications for FRC.
5.8 Role of Bioactive Glass5.9 The First Clinical Tests; 5.10 Future Aspects; References; 6: Translational Oral Health Research Implants and Bone Regeneration; 6.1 Introduction; 6.2 Surgical Placement Protocols; 6.3 Immediate Implants; 6.4 Early Implants; 6.5 Ridge Preservation; 6.6 Bone Regeneration of Residual Alveolar Ridges; 6.7 Future Technologies; References; 7: A Critical Reason for Conducting Clinical Trials Is that Results with Humans Are Not Necessarily Predictable from Preclinical Studies; 7.1 Introduction; 7.2 Cystic Fibrosis; 7.3 SCID X1.
2.4 Assessment of Disease Severity and Treatment Responses in Oral Mucosal Disease2.5 Bullous Diseases; 2.6 Orofacial Granulomatosis; 2.7 Sjögren's Syndrome Clinic; 2.8 Clinical Oral Dryness Score (Fig. 2.7); References; 3: Epigenetics and Periodontitis: A Source of Connection to Systemic Diseases; 3.1 Introduction; 3.1.1 Molecular Regulation of the Immune Response; 3.1.2 Epigenetic Modifications of Gene Expression; 3.1.3 Immune Response in Periodontitis and Epigenetic Modifications; 3.1.4 DNA Methylation, Histone Modulation, and Other Gene Alterations; 3.2 Role of MicroRNAs.
3.3 Role of Long Noncoding RNAs3.4 Periodontitis, Epigenetic Alterations, and Systemic Diseases; 3.4.1 Obesity; 3.4.2 Cardiovascular Disease; 3.4.3 Rheumatoid Arthritis; 3.4.4 Cancer; 3.5 Concluding Remarks; References; 4: Topic: aMMP-8 Oral Fluid PoC Test; 4.1 Introduction; 4.2 Periodontal Health Versus Periodontal Inflammation and Clinical Measuring; 4.3 Validity, Sensitivity, and Specificity of Neutrophil Collagenase-2 (aMMP-8) System; 4.4 Justification for aMMP-8 Chairside Test in Reproductive Health Parameters.
4.5 Effect of Chronic Periodontitis on Erectile Dysfunction and Sperm Count4.6 Association Between Periodontitis and Conception; 4.7 Emerging Racial Differences on Chronic Periodontitis and Pregnancy Outcomes; 4.8 Role of aMMP-8 Chairside Test in Specific Periodontal Health Parameters; References; 5: Composite Biomaterials: From Lab to Clinics; 5.1 Introduction; 5.2 Dental Applications for FRC; 5.3 All Started from Removable Dentures; 5.4 Next Step: Fixed Dental Prostheses; 5.5 Into the Root Canal; 5.6 To Replace Amalgam; 5.7 Into Bone: Surgical Applications for FRC.
5.8 Role of Bioactive Glass5.9 The First Clinical Tests; 5.10 Future Aspects; References; 6: Translational Oral Health Research Implants and Bone Regeneration; 6.1 Introduction; 6.2 Surgical Placement Protocols; 6.3 Immediate Implants; 6.4 Early Implants; 6.5 Ridge Preservation; 6.6 Bone Regeneration of Residual Alveolar Ridges; 6.7 Future Technologies; References; 7: A Critical Reason for Conducting Clinical Trials Is that Results with Humans Are Not Necessarily Predictable from Preclinical Studies; 7.1 Introduction; 7.2 Cystic Fibrosis; 7.3 SCID X1.