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Table of Contents
Intro; Foreword; Preface; Acknowledgement; Abbreviations; Contents; Part I: Pathology; 1: Diagnostic Confusion Through the Ages; Introduction; True Flatulent Asthma; Page X; Page XXVIII; Page 5; Page 6; Page 9; Page 10; Page 23; Page 176; References; 2: An Overview of Gastroesophageal Reflux Disease; Definition and Clinical Manifestations; Epidemiology; Diagnosis; Proton Pump Inhibitor Trial; Upper Gastrointestinal Endoscopy; Indications for First Upper Gastrointestinal Endoscopy; Indications for Follow-Up Upper Gastrointestinal Endoscopy; 24-h Ambulatory pH or pH-Impedance Monitoring.
Indications for 24-h Impedance-pH MonitoringWireless pH Monitoring; Oesophageal Manometry; Other Tests; Medical, Endoscopic and Surgical Therapy; Lifestyle Modifications; Medical Therapy; Endoluminal Therapies; Anti-reflux Surgery; Summary of the Therapeutic Approach; Status of Newer Medications; Improved Acid Suppression; Helicobacter pylori and GORD; References; 3: Chemical Composition of Refluxate; Introduction; Overview of Gastric Secretions; Control of Gastric Secretion; The Gastric Microbiome; Refluxate and Other Non-gastric Secretions; Dietary Intake and Reflux; Summary; References.
4: Pathological ProcessesPutative Mechanisms for Reflux/Aspiration Leading to Inflammation; Animal Models; Cell Models; Human Studies; Summary; References; 5: Pathophysiology in the Lung; Gastro Oesophageal Reflux and Aspiration Occurs Normally in Humans; Lung Diseases Associated with GOR and Aspiration; Parenchymal Disease (See Also Chap. 16); Airways Disease; COPD; Asthma; Cystic Fibrosis (CF); Non-cystic Fibrosis Bronchiectasis (NCFB); BOS Post Lung Transplantation; The Role of a Mixed Disciplinary Aerodigestive Team Approach; Questions Raised by This Chapter; What Is Normal?
The Importance of the MicrobiomeUnderstanding Therapy; Interrelationships Between Lung and Gastrointestinal Pathophysiology: The Chicken and Egg of Reflux and Aspiration; The Role of Surgical Fundoplication; References; 6: Effect of Reflux on Cough Sensitivity and Bronchial Responsiveness; Introduction; Reflux and Cough Reflex Sensitivity; Reflux and Bronchial Responsiveness; References; Part II: Diagnosis; 7: Questionnaire Diagnosis of Airways Reflux; Introduction; Airway Reflux Questionnaires; Reflux Symptom Index (RSI); Supraesophageal Reflux Questionnaire (SERQ).
Pharyngeal Reflux Symptom Questionnaire (PRSQ)Hull Airways Reflux Questionnaire (HARQ); Composite Questionnaires; Discussion; References; 8: Pepsin Detection as a Diagnostic Test for Reflux Disease; Introduction; History of Reflux; History of Pepsin; Reflux Diagnostic Tests: Invasive and Non-invasive; Methods; Patient Recruitment; Sample Collection; Pepsin Analysis; Results; Discussion; References; 9: Imaging Reflux; Introduction; X-ray; Nuclear Medicine; Magnetic Resonance Imaging; References; 10: High Resolution Oesophageal Manometry in the Investigation of Unexplained Cough; Introduction.
Indications for 24-h Impedance-pH MonitoringWireless pH Monitoring; Oesophageal Manometry; Other Tests; Medical, Endoscopic and Surgical Therapy; Lifestyle Modifications; Medical Therapy; Endoluminal Therapies; Anti-reflux Surgery; Summary of the Therapeutic Approach; Status of Newer Medications; Improved Acid Suppression; Helicobacter pylori and GORD; References; 3: Chemical Composition of Refluxate; Introduction; Overview of Gastric Secretions; Control of Gastric Secretion; The Gastric Microbiome; Refluxate and Other Non-gastric Secretions; Dietary Intake and Reflux; Summary; References.
4: Pathological ProcessesPutative Mechanisms for Reflux/Aspiration Leading to Inflammation; Animal Models; Cell Models; Human Studies; Summary; References; 5: Pathophysiology in the Lung; Gastro Oesophageal Reflux and Aspiration Occurs Normally in Humans; Lung Diseases Associated with GOR and Aspiration; Parenchymal Disease (See Also Chap. 16); Airways Disease; COPD; Asthma; Cystic Fibrosis (CF); Non-cystic Fibrosis Bronchiectasis (NCFB); BOS Post Lung Transplantation; The Role of a Mixed Disciplinary Aerodigestive Team Approach; Questions Raised by This Chapter; What Is Normal?
The Importance of the MicrobiomeUnderstanding Therapy; Interrelationships Between Lung and Gastrointestinal Pathophysiology: The Chicken and Egg of Reflux and Aspiration; The Role of Surgical Fundoplication; References; 6: Effect of Reflux on Cough Sensitivity and Bronchial Responsiveness; Introduction; Reflux and Cough Reflex Sensitivity; Reflux and Bronchial Responsiveness; References; Part II: Diagnosis; 7: Questionnaire Diagnosis of Airways Reflux; Introduction; Airway Reflux Questionnaires; Reflux Symptom Index (RSI); Supraesophageal Reflux Questionnaire (SERQ).
Pharyngeal Reflux Symptom Questionnaire (PRSQ)Hull Airways Reflux Questionnaire (HARQ); Composite Questionnaires; Discussion; References; 8: Pepsin Detection as a Diagnostic Test for Reflux Disease; Introduction; History of Reflux; History of Pepsin; Reflux Diagnostic Tests: Invasive and Non-invasive; Methods; Patient Recruitment; Sample Collection; Pepsin Analysis; Results; Discussion; References; 9: Imaging Reflux; Introduction; X-ray; Nuclear Medicine; Magnetic Resonance Imaging; References; 10: High Resolution Oesophageal Manometry in the Investigation of Unexplained Cough; Introduction.