Standards for ocular toxicology and inflammation / Brian C. Gilger, Cynthia S. Cook, Michael H. Brown, editors.
Gilger, Brian C., editor.; Cook, Cynthia S., editor.; Brown, Michael H., editor.
2018
RE901.T67
Available Online

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Title Standards for ocular toxicology and inflammation / Brian C. Gilger, Cynthia S. Cook, Michael H. Brown, editors.
ISBN 9783319783642 (electronic book)
3319783645 (electronic book)
9783319783635
3319783637
DOI https://doi.org/10.1007/978-3-319-78364-2
Published Cham : Springer, 2018.
Language English
Description 1 online resource
Item Number 10.1007/978-3-319-78364-2 doi
Call Number RE901.T67
Dewey Decimal Classification 616.7/1
Summary This book is an international effort to standardize the language, terms, and methods used in ocular toxicology. With over 300 color illustrations this consensus volume provides standards and harmonization for procedures, terminology, and scoring schemes for ocular toxicology. It is essential for industry, pharmaceutical companies, and governmental agencies to help improve the drug development process and to reduce and refine the use of animals in research. Standards for Ocular Toxicology and Inflammation is endorsed by the American College of Veterinary Ophthalmologists.
Access Note Access limited to authorized users.
Digital File Characteristics text file PDF
Source of Description Online resource; title from PDF title page (viewed September 6, 2018).
Added Author Gilger, Brian C., editor.
Cook, Cynthia S., editor.
Brown, Michael H., editor.
Available in Other Form Standards for ocular toxicology and inflammation.
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Intro; Preface; Contents; Chapter 1: Standards for Conducting Ophthalmic Examinations in Laboratory Animals; Introduction; Routine Examination; Slit-Lamp Biomicroscopy; Indirect/Direct Ophthalmoscopy; Pretest Examination; Additional Ophthalmic Diagnostic Procedures; Tonometry; Pachymetry; Fluorescein Staining; Photographic Documentation; Fluorescein Angiography; Electroretinography/Visual Evoked Potential; Optical Coherence Tomography; Specular Microscopy; Conclusion; References; Chapter 2: Standard Operating Procedures for Common Laboratory Animal Ocular Procedures; Introduction.

Aqueocentesis/Intracameral InjectionIntravitreal Injection/Vitreocentesis; Mouse; Rat; Rabbit; Porcine/Canine; Nonhuman Primates; Subconjunctival Injection; Retrobulbar; Subretinal Injections; Rodents; Large Animals; Rabbit; Porcine/Canine; Nonhuman Primate; Globe/Tissue Dissection for Ocular Drug Analysis and Pharmacokinetics; Conclusions; References; Chapter 3: Harmonization of Lesion Nomenclature in Laboratory Animals; Introduction; Orbit and Globe; Eyelids, Adnexa, and Conjunctiva; Cornea and Sclera; Aqueous/Anterior Chamber; Iris and Ciliary Body; Lens; Vitreous Humor.

Retina, Choroid, and Optic NerveNeuro-Ophthalmology; Conclusions; References; For Additional Information of the SEND and INHAND Initiatives, Please See These Additional Resources:; Chapter 4: Spontaneous Incidence of Ocular Abnormalities in Laboratory Animals; Introduction; Rodents; CD-1 Mice; Sprague-Dawley Rat; CD Rats; Wistar Rats; Long-Evans Rats; Other Rodent Species; Guinea Pig; Hamster; Rabbits; Beagles; Laboratory Minipigs; Cynomolgus Monkeys; Conclusions; References; Chapter 5: Standardized Scoring of Ocular Findings in the Context of Drug and Device Development Programs.

Introduction and BackgroundScoring of the Anterior Segment; The Standardization of Uveitis Nomenclature (SUN) System; The McDonald-Shadduck and Hackett-McDonald Systems; The Semi-quantitative Preclinical Ocular Toxicology Scoring (SPOTS) System: Anterior Segment; Pupillary Light Reflex (PLR); Conjunctiva; Corneal Opacity and Fluorescein Staining; Corneal Vascularization; Aqueous (Anterior Chamber) Flare; Aqueous (Anterior Chamber) Cell; Iris Involvement; Anterior Vitreous Cell; Lens Opacity; The SPOTS
Modified SUN System; Scoring of the Posterior Segment.

The National Eye Institute (NEI) Scoring System for Vitreous InflammationThe SPOTS Scoring System: Posterior Segment; Vitreous Haze; Degraded Fundus View; Retinal Perivascular Sheathing; Intravitreal Test Articles; Scoring System Modifications; Species-Specific Considerations for Ocular Scoring; Rodents (Mice and Rats); Rabbits; Dogs; Pigs; Nonhuman Primates; Conclusion; References; Index.

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