Human neural stem cells : from generation to differentiation and application / Leonora Buzanska, editor.
Buzanska, Leonora, editor.
2018
QP356.25
Available Online

Linked e-resources

Linked Resource Online Access
Concurrent users Unlimited
Authorized users Authorized users
Document Delivery Supplied Can lend chapters, not whole ebooks

Details

Title Human neural stem cells : from generation to differentiation and application / Leonora Buzanska, editor.
ISBN 9783319934853 (electronic book)
3319934856 (electronic book)
9783319934846
3319934848
DOI https://doi.org/10.1007/978-3-319-93485-3
Published Cham, Switzerland : Springer, [2018]
Language English
Description 1 online resource.
Other Standard Identifiers 10.1007/978-3-319-93485-3 doi
Call Number QP356.25
Dewey Decimal Classification 612.8
Summary This book summarizes early pioneering achievements in the field of human neural stem cell (hNSC) research and combines them with the latest advances in stem cell technology, including reprogramming and gene editing. The powerful potential of hNSC to generate and repair the developing and adult CNS has been confirmed by numerous experimental in vitro and in vivo studies. The book presents methods for hNSC derivation and discusses the mechanisms underlying NSC in vitro fate decisions and their in vivo therapeutic mode of action. The long-standing dogma that the human central nervous system (CNS) lacks the ability to regenerate was refuted at the end of the 20th century, when evidence of the presence of neurogenic zones in the adult human brain was found. These neurogenic zones are home to human neural stem cells (hNSCs), which are capable of self-renewing and differentiating into neurons, astrocytes and oligodendrocytes. NSCs isolated from human CNS have a number of clinical advantages, especially the innate potential to differentiate into functional neural cells. Nevertheless, their full clinical exploitation has been hindered by limited access to the tissue and low expansion potential. The search for an alternative to CNS sources of autologous, therapeutically competent hNSCs was the driving force for the many studies proving the in vitro plasticity of different somatic stem cells to generate NSCs and their functional progeny. Now the era of induced pluripotent stem cells has opened entirely new opportunities to achieve research and therapeutic goals with the aid of hNSCs.
Bibliography, etc. Note Includes bibliographical references.
Access Note Access limited to authorized users.
Digital File Characteristics text file PDF
Source of Description Online resource; title from PDF title page (viewed September 18, 2018).
Added Author Buzanska, Leonora, editor.
Series Results and problems in cell differentiation ; 66.
Available in Other Form Print version: 9783319934846
Linked Resources Online Access
Record Appears in Online Resources > Ebooks
All Resources
Intro; Contents; Part I: Derivation and/or Generation of Human Neural Stem Cells; Chapter 1: Derivation of Neural Stem Cells from the Developing and Adult Human Brain; 1.1 Foetal Neural Stem Cells (NSCs); 1.1.1 Mitogens Used for In Vitro Proliferation of hNSCs; 1.1.2 Longer-Term Growth of hNSCs; 1.1.3 Regional Differences; 1.2 Adult Neural Stem Cells; 1.3 Good Manufacturing Practice Production; 1.4 Conclusion; References; Chapter 2: Human Somatic Stem Cell Neural Differentiation Potential; 2.1 Afterbirth Somatic Tissues; 2.1.1 Placenta; 2.1.1.1 Maternal Decidua-Derived Cells

2.1.1.2 Fetal Chorion-Derived Cells2.1.2 Amnion and Amniotic Fluid; 2.1.2.1 Amniotic Epithelial-Derived Cells; 2.1.2.2 Amnion Mesenchyme-Derived Cells; 2.1.2.3 Amniotic Fluid-Derived Cells; 2.1.3 The Umbilical Cord; 2.1.3.1 Human Umbilical Cord Blood (hUCB); 2.1.3.2 Human Umbilical Cord Tissue (Wharton Jelly); 2.2 Adult Somatic Tissues; 2.2.1 Blood; 2.2.1.1 Menstrual Blood; 2.2.1.2 Peripheral Blood; 2.2.2 Bone Marrow; 2.3 Direct Comparison of the Neural Differentiation Capabilities of the Perinatal and Adult Somatic Tissues; 2.4 Conclusions; References

Chapter 3: Neural Stem Cells Derived from Human-Induced Pluripotent Stem Cells and Their Use in Models of CNS Injury3.1 Introduction; 3.1.1 iPS-NPs Derivation and Differentiation; 3.1.2 iPS-NPs in the Treatment of Injured CNS; 3.1.3 iPS-NPs in the Treatment of SCI; 3.1.4 iPS-NPs in the Treatment of Acute SCI; 3.1.5 iPS-NPs in the Treatment of Chronic SCI; 3.1.6 iPS-NPs in the Treatment of Stroke; 3.1.7 iPS-NPs and Their Translation to Clinical Medicine; 3.2 Conclusions; References; Chapter 4: Generation of Human Neural Stem Cells by Direct Phenotypic Conversion; 4.1 Introduction

4.1.1 Neural Stem Cells4.1.2 Reprogramming Technology; 4.1.3 Purpose; 4.2 Generation of iNSC; 4.2.1 Generation of Genome-Integrated iNSC; 4.2.2 Generation of Genome Integration-Free iNSC; 4.2.3 Rationale of Direct Phenotypic Conversion; 4.3 Application Fields of iNSC; 4.3.1 Application Fields of Genome-Integrating iNSC; 4.3.2 Application Fields of Genome Integration-Free iNSC; 4.4 Pros and Cons of iNSC; 4.5 Conclusions and Future Perspectives; References; Part II: Differentiation and Underlying Mechanisms; Chapter 5: Epigenetic Regulation of Human Neural Stem Cell Differentiation

5.1 Introduction5.2 Molecular Mechanisms of Epigenetics; 5.3 Epigenetic Mechanism Regulating Generation of NSCs from Pluripotent Stem Cells and Neuronal Differentiation of NSCs; 5.4 Epigenetic Mechanisms Regulating Astrocytic Differentiation of NSCs; 5.5 Epigenetic Mechanisms Regulating Oligodendrocytic Differentiation of NSCs; 5.6 Investigation of Neurological Disorders Using Patient-Derived iPSCs; 5.7 Concluding Remarks and Perspective; References; Chapter 6: Induced Pluripotent Stem Cells Reveal Common Neurodevelopmental Genome Deprograming in Schizophrenia

Browse Subjects

Show more subjects...

Statistics

from
to
Export