Intro; Preface; Contents; 1: Long Known, Long Ignored: A Brief History of Cytomegalovirus Research; 1.1 Beginnings: 1881-1914; 1.2 Between the Wars: 1914-1930; 1.3 From 1930 to 1960; 1.4 From 1960 to the Present; References; 2: Virus-Host Interaction for Defense and Transmission; 2.1 The Virus; 2.2 The Host; 2.2.1 Cell Types Involved in Replication and Distribution; 2.2.2 The Immune System: Strengths and Weakness; 2.2.2.1 The Innate Immune System; 2.2.2.2 The Adaptive (Acquired) Immune System; 2.2.3 The Placenta: A Barrier?

2.2.4 Cytomegalovirus-Placenta-Fetus: A Slippery Slope Between Defense and TransmissionReferences; 3: Epidemiology: The Influence of Socioeconomic Differences; 3.1 Infant Mortality as a Social Mirror; 3.2 One Effect: Many Causes; 3.2.1 Maternal Etiology; 3.2.2 Fetal Etiology; 3.2.3 Placental Etiology; 3.3 Epidemiology of Congenital CMV Infection; 3.3.1 Congenital CMV and Virus Strains; References; 4: Prospects and Obstacles of Diagnosis; 4.1 Screening for Congenital CMV Infection; 4.1.1 Screening of the Mother; 4.1.2 Screening of the Newborn; 4.2 Diagnosis of Congenital CMV Infection

4.2.1 Prenatal Diagnosis4.2.2 Neonatal Diagnosis; References; 5: Clinical Outcome: Acute Symptoms and Sleeping Hazards; 5.1 Relevance of Connatal CMV Infection for the Pediatrician and Neonatologist; 5.2 The Tip of the Iceberg; 5.3 Lucky Chance by Neonatal Immune Response; 5.4 Features of Symptomatic CMV Infection; 5.5 Timing of Infection; 5.6 Symptoms of the Central Nervous System in Detail; 5.6.1 Microcephaly; 5.6.2 Ocular Defects; 5.6.3 Hearing Loss; 5.6.4 Mental and Psychomotor Retardation; 5.6.5 Seizures; 5.7 Unspecific Symptoms in Detail; 5.7.1 Temperature Instability

5.7.2 Perfusion and Rash5.7.3 Lung; 5.7.4 Liver; 5.7.5 Jaundice; 5.7.6 Spleen; 5.7.7 Platelet System; 5.7.8 Anemia; 5.7.9 Gastrointestinal Tract; 5.8 Asymptomatic Infection; 5.9 Differential Diagnosis; References; 6: Prevention and Therapy: More than Trial and Error; 6.1 Antivirals; 6.1.1 Treatment of Pregnant Women; 6.1.2 Treatment of Neonates; 6.2 Passive Immunization; 6.3 Active Immunization (Vaccination); References; 7: How to Save Money: Congenital CMV Infection and the Economy; 7.1 Introduction; 7.2 Methodology; 7.2.1 Incidence-Based Approach; 7.2.2 Cost Calculation

7.2.3 Cost of Sequelae7.2.3.1 Direct Cost Data; 7.2.3.2 Indirect Cost Data; 7.3 Cost of Illness in Germany; 7.3.1 Total Societal Costs; 7.3.1.1 Direct Cost; 7.3.1.2 Indirect Costs; 7.3.2 Sensitivity Analysis; 7.3.3 Impact Through Prevention; 7.4 Discussion; Addendum; References