Preface Chapter 1- Colorectal Cancer Subtypes- the current portrait. 1 Peter Jordan Chapter 2- Targeting colon cancers with mutated BRAF and microsatellite instability. 17 Paulo Matos and Peter Jordan Chapter 3
Targeting KRAS mutant CMS3 subtype by metabolic inhibitors. 50 Oscar Aguilera and Roberto Serna-Blasco Chapter 4- Targeting the PI3K Signalling as a Therapeutic Strategy in Colorectal Cancer. 77 Maria Sofia Fernandes, João Miguel Sanches and Raquel Seruca Chapter 5- Targeting PTEN in colorectal cancers. 117 Larissa Kotelevets, Mark G.H. Scott and Eric Chastre Chapter 6- Wnt signalling-targeted therapy in the CMS2 tumour subtype: a new paradigm in CRC treatment? 162 Cristina Albuquerque and Lucília Pebre Pereira Chapter 7- Impact of the microenvironment on tumour budding in colorectal cancer. 216 Laurent MC Georges, Laurine Verset, Inti Zlobec, Pieter Demetter, Olivier De Wever Chapter 8- Anti-EGFR Therapy to treat metastatic colorectal cancer: not for all 241 Marta Martins, André Mansinho, Raquel Duarte, Soraia Lobo Martins and Luís Costa Chapter 9- miRNAs as modulators of EGFR therapy in colorectal cancer. 282 Diane M. Pereira and Cecília M. P. Rodrigues Index.