MHC Class-I loss and cancer immune escape / Federico Garrido.
2019
RC268.3 .G37 2019
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Can lend chapters, not whole ebooks
Details
Title
MHC Class-I loss and cancer immune escape / Federico Garrido.
Author
ISBN
9783030178642 (electronic book)
3030178641 (electronic book)
3030178641 (electronic book)
Published
Cham, Switzerland : Springer, [2019]
Language
English
Description
1 online resource : illustrations
Item Number
10.1007/978-3-030-17 doi
Call Number
RC268.3 .G37 2019
Dewey Decimal Classification
616.99/4079
Summary
This book is about the escape strategies used by cancer cells to avoid the immune response of the host. The main characters of this story are the "Antigen Presenting Molecules" and the "T Lymphocytes". The former are known as the Major Histocompatibility Complex (MHC): the H-2 and the HLA molecules. The latter are a subgroup of white cells travelling all over our body which are capable to distinguish between "self and non self". Readers will know from the inside about the history of the HLA genetic system and will discover how T lymphocytes recognize and destroy cancer cells. One of the key important questions is: Why tumors arise, develop and metastasize? This book tries to answer this question and will explain how cancer cells become invisible to killer T lymphocytes. The loss of the HLA molecules is a major player in this tumor escape mechanism. Cancer immunotherapy is aimed at stimulating T lymphocytes to destroy tumor cells. However, the clinical response rate is not as high as expected. The molecular mechanisms responsible for MHC/HLA antigen loss play a crucial role in this resistance to immunotherapy. This immune escape mechanism will be discussed in different types of tumors: lung, prostate, bladder and breast...ect. as well as melanoma and lymphoma. This book will be useful to Oncologists, Pathologists and Immunologist that will enter this fascinating area of research. It will be also interesting for biologist, doctoral students and medical residents interested in "Tumor Immunology".
Bibliography, etc. Note
Includes bibliographical references and index.
Access Note
Access limited to authorized users.
Source of Description
Description based on online resource; title from digital title page (viewed on June 25, 2019).
Series
Advances in experimental medicine and biology ; v. 1151.
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Table of Contents
Preface
Introduction
Mhc/Hla Class I Loss In Cancer Cells
Hla Class-I Expression And Cancer Immunotherapy
Hla Class-Ii Expression In Human Tumors
Index.
Introduction
Mhc/Hla Class I Loss In Cancer Cells
Hla Class-I Expression And Cancer Immunotherapy
Hla Class-Ii Expression In Human Tumors
Index.